Antibiabetic efficacy of ellagic acid in streptozotoc-ininduced diabetes mellitus in albino wistar rats

Asian Journal of Pharmaceutical and Clinical Research

Volumn 4, Issue 3, 2011, Pages 124-128

  Malini, Palanisamy ^a   Kanchana, Ganesan ^a   Rajadurai, Murugan ^a  

^a MUTHAYAMMAL COLLEGE OF ARTS AND SCIENCE   (India)

Author keywords

Carbohydrate metabolic enzymes; Diabetes; Ellagic acid; Insulin and C peptide; Streptozotocin

Indexed keywords

C PEPTIDE; ELLAGIC ACID; FRUCTOSE BISPHOSPHATASE; GLUCOSE; GLUCOSE 6 PHOSPHATASE; GLYCOGEN; GLYCOSYLATED HEMOGLOBIN; HEMOGLOBIN; HEXOKINASE; INSULIN; STREPTOZOCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C PEPTIDE BLOOD LEVEL; CONTROLLED STUDY; DIABETES MELLITUS; DRUG DOSE COMPARISON; DRUG EFFICACY; ENZYME ACTIVITY; FEMALE; GLUCOSE BLOOD LEVEL; GLYCOGEN LIVER LEVEL; GLYCOGEN MUSCLE LEVEL; HEMOGLOBIN BLOOD LEVEL; INSULIN BLOOD LEVEL; NONHUMAN; PROTEIN BLOOD LEVEL; RAT; STREPTOZOCIN DIABETES;

EID: 79960100531     PISSN: 09742441     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Georg P, Ludvik B. Lipids and Diabetes. J Clin Basic Cardiol 2000; 3: 159-162.
2. Nyholm B, Porksen N, Juhl CB, Gravholt CH, Butler PC, Weeke J, Veldhuis S, Pincus S, Schimtz O. Assessment of insulin secretion in relatives of patients with type2 (non-insulin-dependent) diabetes mellitus: evidence of early beta-cell dysfunction. Metabolism 2000; 49: 896-905.
3. Yajnik CS. The insulin resistance epidemic in India: fetal origins, later lifestyle, or both? Nutr Rev 2001; 59:1-9.
4. Piedrola G, Novo E, Escober F, Garcia-Robles R. White blood cell count and insulin resistance in patients with coronary artery disease. Ann Endocrinol 2001; 62:7-10.
5. Joy KL, Kuttan R. Antidiabetic activity of Picorrhiza kurroa extract. J Ethnopharmacol 1999; 167:143-148.
6. Akhtar MS, Ali MP. Study of antidiabetic effect of a compound medicinal plant prediction in normal and diabetic rabbits. J Pak Med Anoc 1984; 34: 329-344.
7. Low PA, Nickander KK, Tritschler HJ. The role of oxidative stress and antioxidant treatment in experimental diabetic neuropathy. Diabetes 1997; 46: 38-41.
8. Rerup CC. Drugs producing diabetes through damage of insulin secreting cells. Pharmacological Reviews 1970; 22: 485-518.
9. Stamp N, Out of the quagmire of plant defense hypotheses. The Quarterly Review of Biology 2003; 78: 23-55.
10. Aeschbacher HU, Meier H, Ruch E. Nonmutagenicity in vivo of the food flavonol quercetin. Nutr Cancer 1982; 2: 90.
11. Reinhold U, Seiter S, Ugurel S, Tilgen W. Treatment of progressive pigmented purpura with oral bioflavonoids and ascorbic acid: an open pilot study in 3 patients. J Am Acad Dermatol 1999; 41:207-208.
12. Knekt P, Jarvinen R, Seppanan R, Heliovaara M, Teppo L, Pukkala E, et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997; 146: 223-230.
13. Peterson J, Dwyer J. Taxonomic classification helps identify flavonoid-containing foods on a semiquantitative food frequency questionnaire. J Am Diet Assoc 1998; 98: 682-685.
14. Ali MM, El Kader MA. The Influence of Naringin on the Oxidative State of Rats with Streptozotocin-Induced Acute Hyperglycemia. Z Naturforschung 2004; 59: 726-733.
15. Vattem DA and Shetty K. Biological Function of Ellagic Acid: A Review. Journal of Food Biochemistry 2005; 29: 234-266.
16. Pari L and Latha M, Effect of Cassia auriculata flowers on Blood Sugar Levels, Serum Tissue Lipids in Streptozotocin Diabetic rats. Sing Med J 2002; 43: 617-621.
17. Wieland T, Pfleiderer G. Advances in Enzymology and Related Areas of Molecular Biol. 1963; 25: 329-68.
18. Brandstrup M, Kruk JE, Bruni C. Determination of hexokinase in tissues. J Gerondol 1957; 12: 166-171.
19. Koide H, Oda T. Pathological occurrence of glucose phosphatase in serum in liver diseases. Clin Chem Acta 1959; 4: 554-561.
20. Gancedo JM, Gancedo C. Fructose 1, 6 biphosphatase, phosphor fructo kinase and glucose -6-phosphate dehydrogenase. Prooc Soc Exp Biol Med 1971; 106: 607-609.
21. Al-Attar A, Zari T. Modulatory effects of ginger and clove oils on physiological responses in streptozotocin-induced diabetic rats. Int J Pharmacol 2007; 3: 34-40.
22. Rajasekaran S, Sivagnanam K, Subramanian S. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol reports 2005; 57: 90-96.
23. Doda RF. Diabetes mellitus, In: Kaplan LA, Amadeo JP, eds. Clinical Chemistry. St Louis: Mosby Year Book, 1996: 613-641.
24. Sen S, Kar M, Roy A, Chakraborti AS. Effect of nonenzymatic glycation on functional and structural properties of hemoglobin. Biophys Chem 2005; 113: 289-298.
25. Fonseca V. Clinical significance of targeting postprandial and fasting hyperglycemia in managing type 2 diabetes mellitus. Curr Med Res Opin 2003; 19: 635-641.
26. Kumar PA, Haseeb A, Suryanarayana P, Ehtesham NZ, Reddy GB. Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat. Arch Biochem Biophys 2005; 444: 77-83.
27. Haller MJ, Stalvey MS, Silverstein JH. Predictors of control of diabetes: monitoring may be the key. J Pediatr 2004; 144: 660-661.
28. Whitton PD, Hems, DA. Glycogen synthesis in the perfused liver of streptozotocin-diabetic rats. Biochemical 1975; 150: 153-165.
29. Jung UJ, Lee MK, Jeong KS, Choi MS. The hypoglycemic effects of hesperidin and naringin are partly mediated by hepatic glucose-regulating enzymes in C57BL/KsJ-db/db mice. J Nutr 2004; 134: 2499-2503.
30. Huang X, Vaag A, Hanson M, Weng J, Goop L. Impaired insulin stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic parents is acquired rather than inherited. J Clin Endocrinol Metab 2000; 85: 1584-1590.
31. Hornbrook KR. Synthesis of liver glycogen in starved alloxan diabetic rats. Diabetes 1970; 19: 916-923.
32. Laakso M, Malkki M, Deeb SS. Amino acid substituents in hexokinase II among patients with NIDDM. Diabetes 1995; 44: 330-334.
33. O'Doherty RM, Lehman DL, Telemaque-Potts S, Newgard CB. Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. Diabetes 1999; 48: 2022-2027.
34. Gupta D, Raju J, Prakash J, Baquer NZ. Change in the lipid profile, lipogenic and related enzymes in the livers of experimental diabetic rats: effect of insulin and vanadate. Diabetes Res Clin Pract 1999; 46: 1-7.
35. Mithievre G, Vidal G, Zitovn C, Miriasian C. Glucose-6-phosphatase mRNA and activity are increased to the same extent in liver and kidney of diabetic rats. Diabetes 1996; 45: 891-896.
36. Pari L, Murugan P. Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats. J Basic clin physiol pharmacol 2005; 16: 257-274.
37. Murray RK, Granner DK, Mayes PA, Rodwell VW. Harper's Biochemistry, 25th ed. Stamford, Connecticut:Appleton and Lange; 2000, 610-617.
38. Bailey CJ. Potential new treatments for type 2 diabetes. Trends Pharmacol Sci 2000; 21: 259-265.