A multiple-radical model for radiation action on DNA and the dependence of OER on LET

International Journal of Radiation Biology

Volumn 69, Issue 3, 1996, Pages 351-358

  Michael, B D ^a   Prise, K M ^a  

^a MOUNT VERNON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FREE RADICAL;

ARTICLE; CONTROLLED STUDY; DNA DAMAGE; IONIZING RADIATION; LINEAR ENERGY TRANSFER; MODEL; OXYGEN ENHANCEMENT RATIO; PRIORITY JOURNAL;

ANIMALS; DNA; DNA DAMAGE; DNA REPAIR; FREE RADICALS; LINEAR ENERGY TRANSFER; MODELS, BIOLOGICAL; OXYGEN; REACTIVE OXYGEN SPECIES;

EID: 0029930368     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530096145913     Document Type: Article

References (53)

1. ADAMS, G. E., MCNAUGHTON, G. S. and MICHAEL, B. D., 1968, Pulse radiolysis of sulphur compounds. Part 2: Free radical 'repair' by hydrogen transfer from sulphydryl compounds. Transactions of the Faraday Society, 64, 902-910.
2. ALEXANDER, P. and CHARLESBY, A., 1955. Physico-chemical methods of protection against ionizing radiation. In: Radiobiology Symposium, Liège, (1954). Edited by: Z. M. Bacq and P. Alexander (London: Butterworths), pp. 49-59.
3. ALEXANDER, P., LETT, J. T., KOPP, P. and ITZHAKI, R., 1961, Degradation of dry deoxyribonucleic acid by polonium alpha-particles. Radiation Research, 14, 363-373.
4. ALPER, T., 1965, The modification of damage caused by primary ionization of biological targets. Radiation Research, 5, 573-586.
5. ALPER, T., 1979, Cellular Radiobiology (Cambridge University Press, Cambridge).
6. ALPER, T. and BRYANT, P. E., 1974, Reduction in oxygen enhancement ratio with increase in LET: tests of two hypotheses. International Journal of Radiation Biology, 26, 203-218.
7. ALPER, T. and HOWARD-FLANDERS, P., 1956, Role of oxygen in modifying the radiosenstivity of E. coli B. Nature, 178, 978-979.
8. APPLEBY, A. and SCHWARZ, H. A., 1969, Radical and molecular yields in water irradiated by γ-rays and heavy ions. Journal of Physical Chemistry, 73, 1937-1941.
9. AYENE, I. S., KOCH, G. J. and KRISCH, R. E., 1995, Modification of radiation-induced strand breaks by glutathione: comparison of single and double-strand breaks in SV40 DNA. Radiation Research, 144, 1-8.
10. BAVERSTOCK, K. F. and BURNS, W. G., 1981, Oxygen as a product of water radiolysis in high LET tracks. II: radiobiological implications. Radiation Research, 86, 20-33.
11. BAVERSTOCK, K. F. and WILL, S., 1989, Evidence for the dominance of direct excitation of DNA in the formation of strand breaks in cells following radiation. International Journal of Radiation Biology, 55, 563-568.
12. BOON, P. J., CULLIS, P. M., SYMONS, M. C. R. and WREN, B. W., 1984, Effects of ionizing radiation on deoxyribonucleic acid and related systems. Part 1. The role of oxygen. Journal of the Chemical Society, Perkins Transactions 2, 1393-1399.
13. BLÖCHER, D., 1988, DNA Double strand break repair determines the RBE of α-particles. International Journal of Radiation Biology, 54, 761-771.
14. BRYANT, P. E. and ALPER, T., 1975, Reduction in OER with LET: evidence supporting the 'oxygen-in-the-track' hypothesis. In: 5th Symposium in Microdosimetry. Edited by: J. Booz, H. G. Ebert and B. G. R. Smith. EURATOM, EUR 5452 d-e-f. (Commission of the European Communities, Luxembourg), pp. 871-882.
15. BUMP, E. A., CERCE, B. A., AL-SARRAF, R., PIERCE, S. M. and KOCH, C. J., 1992, Radioprotection of DNA in isolated nuclei by naturally occurring thiols at intermediate oxygen tensions. Radiation Research, 132, 94-104.
16. DELARA, C. M., JENNER, T. J., TOWNSEND, K. M. S., MARSDEN, S. J. and O'NEILL, P., 1995, The effect of dimethyl sulphoxide on the induction of DNA double-strand breaks in V79-4 mammalian cells by alpha-particles. Radiation Research, 144, 43-49.
17. EDGREN, M., NISHIDAI, T., SCOTT, O. C. A. and REVESZ, L., 1985, Combined effect of misonidazole and glutathione depletion by buthionine sulphoximine on cellular radiation response. International Journal of Radiation Biology, 47, 463-474.
18. FAHEY, R. C., PRISE, K. M., STRATFORD, M. R. L., WATFA, R. R. and MICHAEL, B. D., 1991, Rates for repair of pBR322 DNA radicals by thiols as measured by the gas explosion technique: evidence that counter-ion condensation and co-ion depletion are significant at physiological ionic strength. International Journal of Radiation Biology, 59, 901-917.
19. FRANKENBERG, D., FRANKENBERG-SCHWAGER, M. and HARBICH, R., 1993, Mechanisms of oxygen radiosensitisation in irradiated yeast I. DNA double-strand breakage. International Journal of Radiation Biology, 64, 511-521.
20. FRANKENBERG,D., MICHAEL, B. D., FRANKENBERG-SCHWAGER, M. and HARBICH, R., 1990, Fast kinetics of the oxygen effect for DNA double-strand breakage and cell killing in irradiated yeast. International Journal of Radiation Biology, 57, 485-501.
21. FRANKENBERG-SCHWAGER, M., FRANKENBERG, D., HARBICH, R. and BECKONERT, S., 1994, Evidence against the 'Oxygen-in-the-track' hypothesis as an explanation for the radiobiological low oxygen enhancement ratio at high linear energy transfer radiation. Radiation and Environmental Biophysics, 33, 1-8.
22. HELD, K. D., Use of chemical agent radiation modifiers as probes for mechanisms of radiation damage. In: Radiation Damage in DNA: Structure/Function Relationships at Early Times. Edited by: A. Fuciarelli and J. Zimbrick (Battelle. Columbus), pp. 357-176.
23. HELD, K D., HARROP, H. A. and MICHAEL, B. D., 1984, Effects of oxygen and sulphydryl-containing compounds on irradiated transforming DNA. III. Reaction rates. International Journal of Radiation Biology, 45, 627-636.
24. HENDRY, J. H., GILBERT, C. W. and HOWARD, A., 1975, K values and gain factors of fast neutrons and X-rays for a mammalian cell system (CFU) in vivo. Radiation Research, 61, 504-512.
25. HOWARD, A., GILBERT, C. W. and GREENE, D., 1974, Dependence of radiation sensitivity on oxygen tension in Oedogonium. II. Effect of temperature and LET. Radiation Botany, 14, 101-107.
26. 4He ions. Radiation Research, 136, 190-196.
27. KOCH, C. J., 1983, Competition between radiation protectors and radiation sensitisers in mammalian cells. In: Radioprotectors and Anticarcinegens. Edited by: O. F. Nygaard and M. G. Simic (Academic, New York.) pp. 275-296.
28. m for radiosensitization at 0°C of thiol depletion by diethylmaleate pretreatment: quantitative differences found using the radiation-sensitizing agent misonidazole or oxygen. Radiation Research, 98, 141-153.
29. KRISCH, R. E., FLICK, M. B. and TRUMBORE, C. N., 1991, Radiation chemical mechanisms of single and double-strand break formation in irradiated SV40 DNA. Radiation Research, 126, 251-259.
30. LETT, J. T., STACEY, K. A. and ALEXANDER, P., 1961, Crosslinking of dry deoxyribonucleic acids by electrons. Radiation Research, 14, 349-362.
31. LIPHARD, M., BOTHE, E. and SCHULTE-FROHLINDE, D., 1990, The influence of glutathione on single-strand breakage in single-stranded DNA irradiated in aqueous solution in the absence and presence of oxygen. International Journal of Radiation Biology, 58, 589-602.
32. MICHAEL, B. D., ADAMS, G. E., HEWITT, H. B., JONES, W. B. G. and WATTS, M. E., 1973, A post-effect of oxygen in irradiated bacteria: a submillisecond fast mixing study. Radiation Research, 54, 239-251.
33. MICHAEL, B. D., DAVIES, S. and HELD, K. D., 1986, Ultrafast chemical repair of single and double strand break precursors in irradiated V79 cells. In: Mechanisms of DNA Damage and Repair. Edited by: M. G. Simic, L. Grossman and A. D. Upton (Plenum, New York), pp. 89-100.
34. MICHAEL, B. D., PRISE, K. M., FOLKARD, M. and FAHEY, R. C., 1991, Radical multiplicty in radiation-induced DNA strand breaks: Implications for their chemical modification and effects. In: NATO Advanced Research Workshop on Cell Biology: Early Effects of Radiation on DNA. Edited by: E. M. Fielden and P. O'Neill (Springer, Berlin), pp. 333-346.
35. MICHAEL, B. D., PRISE, K. M., FOLKARD, M. and VOJNOVIC, B., 1994, An investigation of clustered radiation induced lesions in DNA. Radiation Protection Dosimetry, 52, 277-281.
36. MILLAR, B. C., FIELDEN, E. M. and STEELE, J. J., 1979, A biphasic radiation survival response of mammalian cells to molecular oxygen. International Journal of Radiation Biology, 36, 177-180.
37. MILLIGAN, J. R., NG, J. Y.-Y., WU, C. C. L., AGUILERA, J. A., FAHEY, R. C. and WARD, J. F., 1995, DNA repair by thiols in air shows two radicals make a double-strand break. Radiation Research, 143, 273-280.
38. MURRAY, D., PRAGER, A., VANANKEREN, S. C., ALTSCHULER, E. M., KERR, M. S. and TERRY, N. H. A., 1990, Comparative effect of the thiols dithiothreitol cysteamine and WR151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to γ-irradiation. International Journal of Radiation Biology, 58, 71-91.
39. NEARY, G. J., 1965, Chromosome aberrations and the theory of RBE. International Journal of Radiation Biology, 9, 477-502.
40. PRÉVOT-BERNAS, A., 1953, Agents de transfert et protection chimique contre les rayonnements ionisants. Journal de Chimie et Physique, 50, 445-446.
41. PRISE, K. M., 1994, Use of radiation quality as a probe for DNA lesion complexity. International Journal of Radiation Biology, 65, 43-48.
42. PRISE, K. M., DAVIES, S. and MICHAEL, B. D., 1992a, Measurement of fast chemical repair of radical precursors of DNA damage and lethal lesions in irradiated Chinese hamster V79 cells. International Journal of Radiation Biology, 61, 721-729.
43. PRISE, K. M., DAVIES, S. and MICHAEL, B. D., 1993, Evidence for induction of DNA double-strand breaks at paired radical sites. Radiation Research, 134, 102-106.
44. PRISE, K. M., DAVIES, S., STRATFORD, M. R. L. and MICHAEL, B. D., 1992b, The role of non-protein sulphydryls in determining the chemical repair rates of free radical precursors of DNA damage and cell killing in Chinese hamster V79 cells. International Journal of Radiation Biology, 62, 297-306.
45. PRISE, K. M., GILLIES, N. E., WHELAN, A., NEWTON, G. L., FAHEY, R. C. and MICHAEL, B. D., 1995, The role of charge in the radioprotection of E. coli by thiols. International Journal of Radiation Biology, 67, 393-401.
46. SCOTT, O. C. A., REVESZ, L. and EDGREN, M., 1993, The X-model: a modified version of the competition theory. International Journal of Radiation Biology, 64, 367-373.
47. SIDDIQI, M. A. and BOTHE, E., 1987, Single- and double-strand break formation in DNA irradiated in aqueous solution: dependence on dose and OH radical scavenger concentration. Radiation Research, 112, 449-463.
48. STUGLIK, Z., 1995, On the 'oxygen in heavy-ion tracks' hypothesis. Radiation Research, 143, 343-348.
49. TĖOULE, R., 1987, Radiation-induced DNA damage and its repair. International Journal of Radiation Biology, 51, 573-589.
50. UDOVICIC, L., MARK, F., BOTHE, E. and SCHULTE-FROHLINDE, D., 1991, Non-homogeneous kinetics in the competition of single-stranded calf-thymus DNA and low molcular weight scavengers for OH radicals: a comparison of experimental data and theoretical models. International Journal of Radiation Biology, 59, 677-697.
51. VON SONNTAG, C., 1987, The Chemical Basis of Radiation Biology (Taylor & Francis, London).
52. WARD, J. F., 1985, Biochemistry of DNA lesions. Radiation Research, 104, S-103-111.
53. WARD, J. F., 1991, Mechanisms of radiation action on DNA in model systems - their relevance to cellular DNA. In: NATO Advanced Research Workshop on Cell Biology: The Early Effects of Radiation on DNA. Edited by: E. M. Fielden and P. O'Neill (Springer, Berlin), pp. 1-16.