LET-painting increases tumour control probability in hypoxic tumours

Acta Oncologica

Volumn 53, Issue 1, 2014, Pages 25-32

  Bassler, Niels ^a,b   Toftegaard, Jakob ^a   Lühr, Armin ^a,b,c   Sorensen, Brita Singers ^b   Scifoni, Emanuele ^d   Krämer, Michael ^d   Jäkel, Oliver ^e   Mortensen, Lise Sakso ^b   Overgaard, Jens ^b   Petersen, Jorgen B ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^d Biophysics Department   (Germany)

^e UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; OXYGEN;

ARTICLE; CELL DENSITY; CELL SURVIVAL; HUMAN; HUMAN CELL; HYPOXIA; LINEAR ENERGY TRANSFER; LINEAR ENERGY TRANSFER PAINTING; OROPHARYNX CANCER; OXYGEN ENHANCEMENT RATIO; PRIORITY JOURNAL; PROBABILITY; RADIATION DOSE DISTRIBUTION; SURVIVAL; TREATMENT PLANNING; TUMOR CONTROL PROBABILITY; TUMOR HYPOXIA; CANCER CONTROL; ENERGY; IN VITRO STUDY; PAINTING; RADIATION RESPONSE; TUMOR VOLUME;

CARBON; CELL HYPOXIA; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; LINEAR ENERGY TRANSFER; OROPHARYNGEAL NEOPLASMS; OXYGEN; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 84890946352     PISSN: 0284186X     EISSN: 1651226X     Source Type: Journal    
DOI: 10.3109/0284186X.2013.832835     Document Type: Article

References (25)

1. Wenzl T, W ilkens JJ. M odelling of the oxygen enhancement ratio for ion beam radiation therapy . Phys Med Biol 2011; 56 : 3251 .
2. Nordsmark M, B entzen SM, R udat V, B rizel D, L artigau E, Stadler P, et al . Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy . An international multi-center study. Radiother Oncol 2005 ; 77 : 18-24 . (Pubitemid 41503384)
3. Nordsmark M, L oncaster J, A quino-Parsons C, C hou S C, Gebski V, West C, et al . The prognostic value of pimonidazole and tumour pO2 in human cervix carcinomas after radiation therapy: A prospective international multi-center study . Radiother Oncol 2006 ; 80 : 123-31 . (Pubitemid 44314011)
4. Brizel D M, S cully S P, H arrelson J M, L ayfi eld L J, B ean J M, Prosnitz LR, et al . Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma . Cancer Res 1996 ; 56 : 941-3 . (Pubitemid 26065381)
5. Goodhead DT . Mechanisms for the biological effectiveness of high-LET radiations . J Radiat Res 1999 ; 40(Suppl) : S1-13 .
6. Duncan W . A n evaluation of the results of neutron therapy trials . Acta Oncol 1994 ; 33 : 299-306 . (Pubitemid 24210794)
7. Kr äm er M, S cifoni E, W äl zlein C, D urante M. I on beams in radiotherapy-from tracks to treatment planning . J Phys Conf Ser 2012; 373 : 012017 .
8. Scifoni E, T inganelli W, W eyrather W, D urante M, M aier A, Kr ä mer M . Including oxygen enhancement ratio in ion beam treatment planning: Model implementation and experimental verifi cation . Phys Med Biol 2013; 58 : 3871 .
9. Bassler N, J ä k el O, S øn dergaard C S, P etersen J B . D ose-and LET-painting with particle therapy . Acta Oncol 2010 ; 49 : 1170-6 .
10. Kr äm er M, S cifoni E, D urante M . M ulti-modal treatment planning with TRiP98 . GSI Sci Rep 2012 ; 2011 : 514 .
11. Grassberger C, T rofi mov A, L omax A, P aganetti H . V ariations in linear energy transfer within clinical proton therapy fi elds and the potential for biological treatment planning . Int J Radiat Oncol Biol Phys 2011 ; 80 : 1559-66 .
12. Thorwarth D, E schmann S M, P aulsen F, A lber M . Hypoxia dose painting by numbers: A planning study . Int J Radiat Oncol Biol Phys 2007 ; 68 : 291-300 . (Pubitemid 46589864)
13. Chang J H, W ada M, A nderson N J, L im Joon D, L ee S T, Gong SJ, et al . Hypoxia-targeted radiotherapy dose painting for head and neck cancer using 18F-FMISO PET: A biological modeling study . Epub Acta Oncol 2013 Jan 15 .
14. Horsman MR, M ortensen LS, P etersen JB, B usk M, Overgaard J . Imaging hypoxia to improve radiotherapy outcome . Nature Rev Clin Oncol 2012 ; 9 : 674-87 .
15. Mortensen L S, J ohansen J, K allehauge J, P rimdahl H, Busk M, Lassen P, et al . FAZA PET/CT hypoxia imaging in patients with squamous cell carcinoma of the head and neck treated with radiotherapy: Results from the DAHANCA 24 trial . Radiother Oncol 2012 ; 105 : 14-20 .
16. Kr äm er M, J ä k el O, H aberer T, K raft G, S chardt D, Weber U . Treatment planning for heavy-ion radiotherapy: Physical beam model and dose optimization . Phys Med Biol 2000 ; 45 : 3299-317 .
17. Hansen D C, L ü hr A, S obolevsky N, B assler N . O ptimizing SHIELD-HIT for carbon ion treatment . Phys Med Biol 2012 ; 57 : 2393-409 .
18. Antonovic L, Brahme A, F urusawa Y, T oma-Dasu I . Radiobiological description of the LET dependence of the cell survival of oxic and anoxic cells irradiated by carbon ions . J Radiat Res 2013 ; 54 : 18-26 .
19. Kr äm er M, J ä k el O . B iological dose optimization using ramp-like dose gradients in ion irradiation fi elds . Phys Med 2005 ; 21 : 107-11 . (Pubitemid 41608015)
20. Gr ü n R, Friedrich [20] T, E ls äs ser T, K rä m er M, Z ink K, Karger CP, et al . Impact of enhancements in the local effect model (LEM) on the predicted RBE-weighted target dose distribu tion in carbon ion therapy . Phys Med Biol 2012 ; 57 : 7261 .
21. Nakano T, S uzuki Y, O hno T, K ato S, S uzuki M, M orita S, et al . Carbon beam therapy overcomes the radiation resistance of uterine cervical cancer originating from hypoxia . Clin Cancer Res 2006; 12 : 2185 .
22. Schulz-Ertner D, N ikoghosyan A, Thilmann C, H aberer T, J ä kel O, Karger C, et al . Results of carbon ion radiotherapy in 152 patients . Int J Radiat Oncol Biol Phys 2004 ; 58 : 631-40 . (Pubitemid 38142491)
23. Schulz-Ertner D, N ikoghosyan A, D idinger B, M ü nter M, J ä kel O, Karger CP, et al . Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques . Cancer 2005 ; 104 : 338-44 . (Pubitemid 40993261)
24. Habermehl D, R ieken S, O rschiedt L, B rons S, H aberer T, Straub B, et al . In vitro evaluation of carbon and oxygen ion irradiation in hepatocellular carcinoma cell lines . Z Gastroenterol 2013; 51 : P419 .
25. Holzscheiter MH, B assler N, D osanjh M, S ør ensen BS, Overgaard J . A community call for a dedicated radiobiological research facility to support particle beam cancer therapy . Radiother Oncol 2012 ; 105 : 1-3 .