Cardiac repolarization in recently postmenopausal women with or without hot flushes

Menopause

Volumn 23, Issue 5, 2016, Pages 528-534

  Lantto, Hanna ^a   Mikkola, Tomi S ^b   Tuomikoski, Pauliina ^b   Viitasalo, Matti ^a   Väänänen, Heikki ^c   Sovijärvi, Anssi R A ^a   Haapalahti, Petri ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b Department of Obstetrics and Gynecology ^*  (Finland)

^c AALTO UNIVERSITY   (Finland)

Author keywords

Arrhythmia; Electrocardiography; Menopause; QT interval; Vasomotor symptom

Indexed keywords

ESTRADIOL; FOLLITROPIN; SEX HORMONE BINDING GLOBULIN;

ADULT; ARTICLE; BODY MASS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISPERSION; ELECTROCARDIOGRAM; ESTRADIOL BLOOD LEVEL; EXTRASYSTOLE; FEMALE; FOLLITROPIN BLOOD LEVEL; HEART RATE; HEART REPOLARIZATION; HOT FLUSH; HUMAN; HUMAN EXPERIMENT; MIDDLE AGED; NORMAL HUMAN; POSTMENOPAUSE; PQ INTERVAL; PROTEIN BLOOD LEVEL; QRS COMPLEX; QT INTERVAL; R WAVE; RR INTERVAL; T WAVE; ADRENERGIC SYSTEM; AMBULATORY ELECTROCARDIOGRAPHY; CASE CONTROL STUDY; HEART MUSCLE CONDUCTION SYSTEM; PATHOPHYSIOLOGY; PHYSIOLOGY;

CASE-CONTROL STUDIES; ELECTROCARDIOGRAPHY, AMBULATORY; FEMALE; HEALTHY VOLUNTEERS; HEART CONDUCTION SYSTEM; HEART RATE; HOT FLASHES; HUMANS; MIDDLE AGED; POSTMENOPAUSE; SYMPATHETIC NERVOUS SYSTEM;

EID: 84947997280     PISSN: 10723714     EISSN: 15300374     Source Type: Journal    
DOI: 10.1097/GME.0000000000000564     Document Type: Article

References (41)

1. James AF, Choisy SC, Hancox JC. Recent advances in understanDing sex differences in cardiac repolarization. Prog Biophys Mol Biol 2007; 94:265-319.
2. Sedlak T, Shufelt C, Iribarren C, Merz CN. Sex hormones and the QT interval: a review. J Womens Health (Larchmt) 2012;21:933-941.
3. Gowda RM, Khan IA, Wilbur SL, Vasavada BC, Sacchi TJ. Torsade de pointes: the clinical considerations. Int J Cardiol 2004;96:1-6.
4. Saba S, Link MS, Homoud MK, Wang PJ, Estes NA III. Effect of low estrogen states in healthy women on dispersion of ventricular repolarization. Am J Cardiol 2001;87:354-356, A9-A10.
5. Gokce M, Karahan B, Yilmaz R, Orem C, Erdol C, Ozdemir S. Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhythmia. Int J Cardiol 2005;99:373-379.
6. Buber J, Mathew J, Moss AJ, et al. Risk of recurrent cardiac events after onset of menopause in women with congenital long-QT syndrome types 1 and 2. Circulation 2011;123:2784-2791.
7. Hoikkala H, Haapalahti P, Viitasalo M, et al. Association between vasomotor hot flashes and heart rate variability in recently postmenopausal women. Menopause 2010;17:315-320.
8. Thurston RC, Christie IC, Matthews KA. Hot flashes and cardiac vagal control during women's daily lives. Menopause 2012;19:406-412.
9. Thayer JF, Lane RD. The role of vagal function in the risk for cardiovascular disease and mortality. Biol Psychol 2007;74:224-242.
10. Nakagawa M, Ooie T, Ou B, et al. Gender differences in autonomic modulation of ventricular repolarization in humans. J Cardiovasc Electrophysiol 2005;16:278-284.
11. Shimizu W, Antzelevitch C. Differential effects of beta-adrenergic agonists and antagonists in LQT1, LQT2 and LQT3 models of the long QT syndrome. J Am Coll Cardiol 2000;35:778-786.
12. Magnano AR, Holleran S, Ramakrishnan R, Reiffel JA, Bloomfield DM. Autonomic nervous system influences on QT interval in normal subjects. J Am Coll Cardiol 2002;39:1820-1826.
13. Xhaet O, Argacha JF, Pathak A, et al. Sympathoexcitation increases the QT/RR slope in healthy men: differential effects of hypoxia, dobutamine, and phenylephrine. J Cardiovasc Electrophysiol 2008;19:178-184.
14. Yan GX, Antzelevitch C. Cellular basis for the normal T wave and the electrocardiographic manifestations of the long-QT syndrome. Circulation 1998;98:1928-1936.
15. Gbadebo TD, Trimble RW, Khoo MS, Temple J, Roden DM, Anderson ME. Calmodulin inhibitor W-7 unmasks a novel electrocardiographic parameter that predicts initiation of torsade de pointes. Circulation 2002;105:770-774.
16. Tuomikoski P, Ebert P, Groop PH, et al. Evidence for a role of hot flushes in vascular function in recently postmenopausal women. Obstet Gynecol 2009;113:902-908.
17. Notelovitz M, Lenihan JP, McDermott M, Kerber IJ, Nanavati N, Arce J. Initial 17beta-estradiol dose for treating vasomotor symptoms. Obstet Gynecol 2000;95:726-731.
18. Sloan JA, Loprinzi CL, Novotny PJ, Barton DL, Lavasseur BI, Windschitl H. Methodologic lessons learned from hot flash studies. J Clin Oncol 2001;19:4280-4290.
19. Lantto H, Haapalahti P, Tuomikoski P, et al. Vasomotor hot flashes and heart rate variability: a placebo-controlled trial of postmenopausal hormone therapy. Menopause 2012;19:82-88.
20. Viitasalo M, Oikarinen L, Swan H, et al. Ambulatory electrocardiographic evidence of transmural dispersion of repolarization in patients with long-QT syndrome type 1 and 2. Circulation 2002;106:2473-2478.
21. Viitasalo M, Oikarinen L, Swan H, et al. Effects of beta-blocker therapy on ventricular repolarization documented by 24-h electrocardiography in patients with type 1 long-QT syndrome. J Am Coll Cardiol 2006; 48:747-753.
22. Viitasalo M, Oikarinen L, Väänänen H, et al. Differentiation between LQT1 and LQT2 patients and unaffected subjects using 24-hour electrocardiographic recordings. Am J Cardiol 2002;89:679-685.
23. Merri M, Moss AJ, Benhorin J, Locati EH, Alberti M, Badilini F. Relation between ventricular repolarization duration and cardiac cycle length during 24-hour Holter recordings: findings in normal patients and patients with long QT syndrome. Circulation 1992;85: 1816-1821.
24. Järvenpää J, Oikarinen L, Korhonen P, Väänänen H, Toivonen L, Viitasalo M. Dynamic QT/RR relationship in post-myocardial infarction patients with and without cardiac arrest. Scand Cardiovasc J 2010;44:352-358.
25. Viitasalo M, Oikarinen L, Swan H, et al. Ratio of late to early T-wave peak amplitude in 24-h electrocardiographic recordings as indicator of symptom history in patients with long-QT syndrome types 1 and 2. J Am Coll Cardiol 2006;47:112-120.
26. Tuomikoski P, Ebert P, Groop PH, et al. Effect of hot flushes on vascular function: a randomized controlled trial. Obstet Gynecol 2009;114:777-785.
27. Freedman RR. Hot flashes: behavioral treatments, mechanisms, and relation to sleep. Am J Med 2005;118(suppl 12B):124-130.
28. Viitasalo M, Karjalainen J. QT intervals at heart rates from 50 to 120 beats per minute during 24-hour electrocardiographic recordings in 100 healthy men. effects of atenolol. Circulation 1992;86:1439-1442.
29. Iacoviello M, Forleo C, Guida P, et al. Ventricular repolarization dynamicity provides independent prognostic information toward major arrhythmic events in patients with idiopathic dilated cardiomyopathy. J Am Coll Cardiol 2007;50:225-231.
30. Vaseghi M, Yamakawa K, Sinha A, et al. Modulation of regional dispersion of repolarization and T-peak to T-end interval by the right and left stellate ganglia. Am J Physiol Heart Circ Physiol 2013; 305:H1020-H1030.
31. Takenaka K, Ai T, Shimizu W, et al. Exercise stress test amplifies genotype-phenotype correlation in the LQT1 and LQT2 forms of the long-QT syndrome. Circulation 2003;107:838-844.
32. Haapalahti P, Viitasalo M, Perhonen M, et al. Ventricular repolarization and heart rate responses during cardiovascular autonomic function testing in LQT1 subtype of long QT syndrome. Pacing Clin Electrophysiol 2006;29:1122-1129.
33. Schwartz PJ, Priori SG, Spazzolini C, et al. Genotype-phenotype correlation in the long-QT syndrome: Gene-specific triggers for life-threatening arrhythmias. Circulation 2001;103:89-95.
34. Nakamura H, Kurokawa J, Bai CX, et al. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation 2007; 116:2913-2922.
35. Kurokawa J, Tamagawa M, Harada N, et al. Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization. J Physiol 2008;586:2961-2973.
36. Curran ME, Splawski I, Timothy KW, Vincent GM, Green ED, Keating MT. A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 1995;80:795-803.
37. Wang Q, Curran ME, Splawski I, et al. Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nat Genet 1996;12:17-23.
38. Haseroth K, Seyffart K, Wehling M, Christ M. Effects of progestinestrogen replacement therapy on QT-dispersion in postmenopausal women. Int J Cardiol 2000;75:161-165; discussion 165-166.
39. Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB. Estrogen and progestin use and the QT interval in postmenopausal women. Ann Noninvasive Electrocardiol 2004;9:366-374.
40. Vrtovec B, Starc V, Meden-Vrtovec H. The effect of estrogen replacement therapy on ventricular repolarization dynamics in healthy postmenopausal women. J Electrocardiol 2001;34:277-283.
41. Opthof T, Coronel R, Wilms-Schopman FJ, et al. Dispersion of repolarization in canine ventricle and the electrocardiographic T wave: Tp-e interval does not reflect transmural dispersion. Heart Rhythm 2007;4:341-348.