Risk of recurrent cardiac events after onset of menopause in women with congenital long-QT syndrome types 1 and 2

Circulation

Volumn 123, Issue 24, 2011, Pages 2784-2791

  Buber, Jonathan ^a   Mathew, Jehu ^c   Moss, Arthur J ^a   Hall, W Jackson ^b   Barsheshet, Alon ^a   McNitt, Scott ^a   Robinson, Jennifer L ^a   Zareba, Wojciech ^a   Ackerman, Michael J ^d   Kaufman, Elizabeth S ^e   Luria, David ^c   Eldar, Michael ^c   Towbin, Jeffrey A ^f   Vincent, Michael ^g   Goldenberg, Ilan ^a,b  

^a Cardiology Division   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^c SHEBA MEDICAL CENTER   (Israel)

^d Mayo Clinic   (United States)

^e Reserve University ^*  (United States)

^f UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

estrogen; long QT syndrome; testosterone; women

Indexed keywords

ADULT; ARTICLE; CARDIOVASCULAR RISK; CONTROLLED STUDY; ESTROGEN THERAPY; FEMALE; FOLLOW UP; GENOTYPE; HEART ARREST; HUMAN; LONG QT SYNDROME; MAJOR CLINICAL STUDY; MENOPAUSE; POSTMENOPAUSE; PRIORITY JOURNAL; RECURRENCE RISK; REPRODUCTION; RISK ASSESSMENT; RISK REDUCTION; STATISTICAL ANALYSIS; SUDDEN DEATH; SYNCOPE;

ADULT; AGE DISTRIBUTION; DEATH, SUDDEN, CARDIAC; ESTROGEN REPLACEMENT THERAPY; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; FOLLOW-UP STUDIES; GENOTYPE; HUMANS; JERVELL-LANGE NIELSEN SYNDROME; KCNQ1 POTASSIUM CHANNEL; MENOPAUSE; MIDDLE AGED; RECURRENCE; RISK FACTORS; ROMANO-WARD SYNDROME; SYNCOPE;

EID: 79959499716     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.110.000620     Document Type: Article

References (44)

1. Schwartz PJ, Crotti L. Long QT and short QT syndromes. In: Zipes DP, Jalife J, eds. Cardiac Electrophysiology: From Cell to Bedside. 5th ed. Philadelphia, PA: Elsevier/Saunders; 2009:731-744.
2. Vincent GM. The long QT and Brugada syndromes: causes of unexpected syncope and sudden cardiac death in children and young adults. Semin Pediatr Neurol. 2005;1:15-24. (Pubitemid 40558910)
3. Locati EH, Zareba W, Moss AJ, Schwartz PJ, Vincent GM, Lehmann MH, Towbin JA, Priori SG, Napolitano C, Robinson JL, Andrews M, Timothy K, Hall WJ. Age- and sex-related differences in clinical manifestations in patients with congenital long-QT syndrome: findings from the International LQTS Registry. Circulation. 1998;97:2237-2244. (Pubitemid 28265385)
4. Zareba W, Moss AJ, Locati EH, Lehmann MH, Peterson DR, Hall WJ, Schwartz PJ, Vincent GM, Priori SG, Benhorin J, Towbin JA, Robinson JL, Andrews ML, Napolitano C, Timothy K, Zhang L, Medina A. International Long QT Syndrome Registry: modulating effects of age and gender on the clinical course of long QT syndrome by genotype. J Am Coll Cardiol. 2003;42:103-109. (Pubitemid 36760769)
5. Seth R, Moss AJ, McNitt S, Zareba W, Andrews ML, Qi M, Robinson JL, Goldenberg I, Ackerman MJ, Benhorin J, Kaufman ES, Locati EH, Napolitano C, Priori SG, Schwartz PJ, Towbin JA, Vincent GM, Zhang L. Long QT syndrome and pregnancy. J Am Coll Cardiol. 2007;49:1092-1098. (Pubitemid 46349501)
6. Lehmann MH, Hardy S, Archibald D, quart B, MacNeil DJ. Sex difference in risk of torsade de pointes with d, l-sotalol. Circulation. 1996;94:2535-2541.
7. Makkar RR, Fromm BS, Steinman RT, Meissner MD, Lehmann MH. Female gender as a risk factor for torsades de pointes associated with cardiovascular drugs. JAMA. 1993;270:2590-2597. (Pubitemid 23346699)
8. Drici MD, Knollmann BC, Wang WX, Woosley RL. Cardiac actions of erythromycin: influence of female sex. JAMA. 1998;280:1774-1776. (Pubitemid 28536879)
9. James AF, Choisy SC, Hancox JC. Recent advances in understanding sex differences in cardiac repolarization. Prog Biophys Mol Biol. 2007;94:265-319. (Pubitemid 46766581)
10. Rodriguez I, Kilborn MJ, Liu XK, Pezzullo JC, Woosley RL. Drug-induced QT prolongation in women during the menstrual cycle. JAMA. 2001;285:1322-1326. (Pubitemid 32216147)
11. Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 2007;116:2913-2922. (Pubitemid 350291198)
12. Kurokawa J, Tamagawa M, Harada N, Honda S, Bai CX, Nakaya H, Furukawa T. Acute effects of oestrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization. J Physiol. 2008;586:2961-2973. (Pubitemid 351837288)
13. Moss AJ, Schwartz PJ, Crampton RS, Tzivoni D, Locati EH, MacCluer J, Hall WJ, Weitkamp L, Vincent GM, Garson A Jr. The long QT syndrome: prospective longitudinal study of 328 families. Circulation. 1991;84:1136-1144.
14. Bazett HC. An analysis of the time relations of electrocardiograms. Heart. 1920;7:353-367.
15. Soules MR, Sherman S, Parrott E, Rebar R, Santoro N, Utian W, Woods N. Executive summary: Stages of Reproductive Aging Workshop (STRAW). Climacteric. 2001;4:267-272. (Pubitemid 34002968)
16. North American Menopause Society. Menopause Guidebook. 6th ed. http://www.menopause.org/MGI.pdf. Accessed July 23, 2010.
17. Prentice RL, Williams BJ, Peterson AV. On the regression-analysis of multivariate failure time data. Biometrika. 1981;68:373-379.
18. Andersen PK, Gill RD. Cox's regression for counting processes: a large sample study. Ann Stat. 1982;10:1100-1120.
19. Lin DY, Wei LJ. The robust inference for the proportional hazards model. J Am Stat Assoc. 1989;84:1074-1078.
20. Song M, Helguera G, Eghbali M, Zhu N, Zarei MM, Olcese R, Toro L, Stefani E. Remodeling of Kv4.3 potassium channel gene expression under the control of sex hormones. J Biol Chem. 2001;276:31883-31890.
21. 2+ channel protein expression by sex hormones. Biochim Biophys Acta. 2002;1569:59-66. (Pubitemid 34165558)
22. Kadish AH, Greenland P, Limacher MC, Frishman WH, Daugherty SA, Schwartz JB. Estrogen and progestin use and the QT interval in postmenopausal women. Ann Noninvasive Electrocardiol. 2004;9:366-374. (Pubitemid 39540338)
23. Sanguinetti MC, Mitcheson JS. Predicting drug-hERG channel interactions that cause acquired long QT syndrome. Trends Pharmacol Sci. 2005;26:119-124. (Pubitemid 40313590)
24. +channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annu Rev Pharmacol Toxicol. 2003;43:441-461. (Pubitemid 37372649)
25. Drici MD, Burklow TR, Haridasse V, Glazer RI, Woosley RL. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation. 1996;94:1471-1474. (Pubitemid 26307281)
26. Hulot JS, Demolis JL, Riviere R, Strabach S, Christin-Maitre S, Funck-Brentano C. Influence of endogenous oestrogens on QT interval duration. Eur Heart J. 2003;24:1663-1667. (Pubitemid 37174906)
27. Fan F, Zou Y, Ma A, Yue Y, Mao W, Ma X. Hormonal changes and somatopsycologic manifestations in the first trimester of pregnancy and post partum. Int J Gynecol Obstet. 2009;105:46-49.
28. Lawrie TA, Hofmeyr GJ, De Jager M, Berk M, Paiker J, Viljoen E. A double-blind randomised placebo controlled trial of postnatal norethis-terone enanthate: the effect on postnatal depression and serum hormones. Br J Obstet Gynaecol. 1998;105:1082-1090. (Pubitemid 28461501)
29. Delvoye P, Demaegd M, Uwayitu-Nyampeta, Robyn C. Serum prolactin, gonadotropins, and estradiol in menstruating and amenorrheic mothers during two years' lactation. Am J Obstet Gynecol. 1978;130:635-639. (Pubitemid 8283185)
30. Bidoggia H, Maciel JP, Capalozza N, Mosca S, Blaksley EJ, Valverde E, Bertran G, Arini P, Biagetti MO, Quinteiro RA. Sex differences on the electrocardiographic pattern of cardiac repolarization: possible role of testosterone. Am Heart J. 2000;140:678-683.
31. Hara M, Danilo P Jr, Rosen MR. Effects of gonadal steroids on ventricular repolarization and on the response to E4031. J Pharmacol Exp Ther. 1998;285:1068-1072. (Pubitemid 28277905)
32. Brouillette J, Trépanier-Boulay C, Fiset C. Effect of androgen deficiency on mouse ventricular repolarization. J Physiol. 2003;546:403-413. (Pubitemid 36175976)
33. Ridley JM, Shuba YM, James AF, Hancox JC. Modulation by testosterone of an endogenous hERG potassium channel current. J Physiol Pharmacol. 2008;59:395-407.
34. Pham TV, Sosunov EA, Anyukhovsky EP, Danilo P Jr, Rosen MR. Testosterone diminishes the proarrhythmic effects of dofetilide in normal female rabbits. Circulation. 2002;106:2132-2136. (Pubitemid 35192821)
35. Rautaharju PM, Zhou SH, Wong S, Calhoun HP, Berenson GS, Prineas R, Davignon A. Sex differences in the evolution of the electrocardio-graphic QT interval with age. Can J Cardiol. 1992;8:690-695.
36. Nelson HD. Menopause. Lancet. 2008;371:760-770. (Pubitemid 351288876)
37. Labrie F, Belanger A, Cusan L, Gomez JL, Candas B. Marked decline in serum concentrations of adrenal C19 sex steroid precursors and conjugated androgen metabolites during aging. J Clin Endocrinol Metab. 1997;82:2396-2402. (Pubitemid 27337846)
38. Nevton CJ, Samuel DL, James VHT. Aromatase activity and concentrations of cortisol, progesterone and testosterone in breast and abdominal adipose tissue. J Steroid Biochem. 1986;24:1033-1039. (Pubitemid 16034847)
39. Folkered EJ, James VHT. Aromatization of steroids in peripheral tissues. J Steroid Biochem. 1983;19:687-690.
40. Szymczak J, Milewicz A, Thijssen JH, Blankenstein MA, Daroszewski J. Concentration of sex steroids in adipose tissue after menopause. Steroids. 1998;63:319-321. (Pubitemid 28265669)
41. Viskin S, Alla SR, Barron HV, Heller K, Saxon L, Kitzis I, Hare GF, Wong MJ, Lesh MD, Scheinman MM. Mode of onset of torsade de pointes in congenital long QT syndrome. J Am Coll Cardiol. 1996;28: 1262-1268. (Pubitemid 26377004)
42. Tan HL. Genotype-specific onset of arrhythmias in congenital long-QT syndrome: possible therapy implications. Circulation. 2006;114:2096-2103. (Pubitemid 44747889)
43. Grubb BP. Neurocardiogenic syncope. N Engl J Med. 2005;352: 1004-1010.
44. Goldenberg I, Moss AJ, Peterson DR, Bradley J, Polonski S, Petersom DE, McNitt S, Zareba W, Andrews ML, Robinson JL, Locati EH, Ackerman MJ, Benhorin J, Kaufman ES, Napolitano C, Priori SG, Qi M, Schwartz PJ, Towbin JA, G. Vincent M, Zhang L. Long QT syndrome after age 40. Circulation. 2008;117:2192-2201.