Sympathoexcitation increases the QT/RR slope in healthy men: Differential effects of hypoxia, dobutamine, and phenylephrine

Journal of Cardiovascular Electrophysiology

Volumn 19, Issue 2, 2008, Pages 178-184

  Xhaët, Olivier ^a   Argacha, Jean Francois ^a   Pathak, Atul ^a,b   Gujic, Marko ^a   Houssiere, Anne ^a   Najem, Boutaïna ^a   Degaute, Jean Paul ^a   Van De Borne, Philippe ^a  

^a ERASME HOSPITAL   (Belgium)

^b TOULOUSE UNIVERSITY HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

DOBUTAMINE; PHENYLEPHRINE;

ADRENERGIC STIMULATION; ADULT; ARTICLE; BODY MASS; CONTROLLED STUDY; DRUG EFFECT; ELECTROCARDIOGRAM; HEART MUSCLE OXYGEN CONSUMPTION; HEART OUTPUT; HEART RATE VARIABILITY; HEART REPOLARIZATION; HOLTER MONITORING; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; OXYGEN BLOOD LEVEL; OXYGEN SATURATION; PRIORITY JOURNAL; QT DISPERSION; QT INTERVAL; RR INTERVAL; SYMPATHETIC INNERVATION; VAGUS NERVE STIMULATION;

ADULT; ANOXIA; DOBUTAMINE; HEART CONDUCTION SYSTEM; HUMANS; MALE; PHENYLEPHRINE; SYMPATHOLYTICS;

EID: 38849179993     PISSN: 10453873     EISSN: 15408167     Source Type: Journal    
DOI: 10.1111/j.1540-8167.2007.01039.x     Document Type: Article

References (43)

1. Ahnve S, Vallin H : Influence of heart rate and inhibition of autonomic tone on the QT interval. Circulation 1982 65 : 435 439.
2. Magnano AR, Holleran S, Ramakrishnan R, Reiffel JA, Bloomfield DM : Autonomic nervous system influences on QT interval in normal subjects. J Am Coll Cardiol 2002 39 : 1820 1826.
3. Zabel M, Franz MR, Klingenheben T, Mansion B, Schultheiss HP, Hohnloser SH : Rate-dependence of QT dispersion and the QT interval: Comparison of atrial pacing and exercise testing. J Am Coll Cardiol 2000 36 : 1654 1658.
4. Alexopoulos D, Rynkiewicz A, Yusuf S, Johnston JA, Sleight P, Yacoub MH : Diurnal variations of QT interval after cardiac transplantation. Am J Cardiol 1988 61 : 482 485.
5. Sredniawa B, Musialik-Lydka A, Jarski P, Kalarus Z, Polonski L : Circadian and sex-dependent QT dynamics. Pacing Clin Electrophysiol 2005 28 (Suppl 1 S211 S216.
6. Ciarka A, Cuylits N, Vachiery JL, Lamotte M, Degaute JP, Naeije R, van de Borne P : Increased peripheral chemoreceptors sensitivity and exercise ventilation in heart transplant recipients. Circulation 2006 113 : 252 257.
7. Buchheit M, Richard R, Doutreleau S, Lonsdorfer-Wolf E, Brandenberger G, Simon C : Effect of acute hypoxia on heart rate variability at rest and during exercise. Int J Sports Med 2004 25 : 264 269.
8. Roche F, Reynaud C, Pichot V, Duverney D, Costes F, Garet M, Gaspoz JM, Barthelemy JC : Effect of acute hypoxia on QT rate dependence and corrected QT interval in healthy subjects. Am J Cardiol 2003 91 : 916 919.
9. Velez-Roa S, Renard M, Degaute JP, van de Borne P : Peripheral sympathetic control during dobutamine infusion: Effects of aging and heart failure. J Am Coll Cardiol 2003 42 : 1605 1610.
10. Binkley PF, Orsinelli DA, Nunziata E, Patterson SP, Khot UN, Puri R, Latcham AP, Pearson AC : Differing autonomic response to dobutamine in the presence and absence of ischemia: Implications for the autonomic contribution to positive inotropic intervention. Am Heart J 1995 130 : 1054 1061.
11. Pagani M, Montano N, Porta A, Malliani A, Abboud FM, Birkett C, Somers VK : Relationship between spectral components of cardiovascular variabilities and direct measures of muscle sympathetic nerve activity in humans. Circulation 1997 95 : 1441 1448.
12. Malik M, Bigger JT, Camm AJ, Kleiger RE, Malliani A, Mass AJ, Schwartz PJ : Heart rate variability. Standards of measurement, physiological interpretation, and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Eur Heart J 1996 17 : 354 381.
13. Haigney MC, Zareba W, Gentlesk PJ, Goldstein RE, Illovsky M, McNitt S, Andrews ML, Moss AJ : QT interval variability and spontaneous ventricular tachycardia or fibrillation in the Multicenter Automatic Defibrillator Implantation Trial (MADIT) II patients. J Am Coll Cardiol 2004 44 : 1481 1487.
14. Piccirillo G, Magnanti M, Matera S, Di Carlo S, De Laurentis T, Torrini A, Marchitto N, Ricci R, Magri D : Age and QT variability index during free breathing, controlled breathing and tilt in patients with chronic heart failure and healthy control subjects. Transl Res 2006 148 : 72 78.
15. Piccirillo G, Magri D, Matera S, Magnanti M, Torrini A, Pasquazzi E, Schifano E, Velitti S, Marigliano V, Quaglione R, Barilla F : QT variability strongly predicts sudden cardiac death in asymptomatic subjects with mild or moderate left ventricular systolic dysfunction: A prospective study. Eur Heart J 2007 28 : 1344 1350.
16. Delius W, Hagbarth KE, Hongell A, Wallin BG : General characteristics of sympathetic activity in human muscle nerves. Acta Physiol Scand 1972 84 : 65 81.
17. Chevalier P, Burri H, Adeleine P, Kirkorian G, Lopez M, Leizorovicz A, Andre-Fouet X, Chapon P, Rubel P, Touboul P : QT dynamicity and sudden death after myocardial infarction: Results of a long-term follow-up study. J Cardiovasc Electrophysiol 2003 14 : 227 233.
18. Pathak A, Curnier D, Fourcade J, Roncalli J, Stein PK, Hermant P, Bousquet M, Massabuau P, Senard JM, Montastruc JL, Galinier M : QT dynamicity: A prognostic factor for sudden cardiac death in chronic heart failure. Eur J Heart Fail 2005 7 : 269 275.
19. Cargill RI, Kiely DG, Lipworth BJ : Left ventricular systolic performance during acute hypoxemia. Chest 1995 108 : 899 902.
20. Velez-Roa S, Kojonazarov B, Ciarka A, Godart P, Naeije R, Somers VK, van de Borne P : Dobutamine potentiates arterial chemoreflex sensitivity in healthy normal humans. Am J Physiol Heart Circ Physiol 2003 285 : H1356 H1361.
21. Gottdiener JS, Bednarz J, Devereux R, Gardin J, Klein A, Manning WJ, Morehead A, Kitzman D, Oh J, Quinones M, Schiller NB, Stein JH, Weissman NJ : American Society of Echocardiography recommendations for use of echocardiography in clinical trials. J Am Soc Echocardiogr 2004 17 : 1086 1119.
22. van de Borne P, Montano N, Zimmerman B, Pagani M, Somers VK : Relationship between repeated measures of hemodynamics, muscle sympathetic nerve activity, and their spectral oscillations. Circulation 1997 96 : 4326 4332.
23. Gourine AV : On the peripheral and central chemoreception and control of breathing: An emerging role of ATP. J Physiol 2005 568 : 715 724.
24. Cappato R, Alboni P, Pedroni P, Gilli G, Antonioli GE : Sympathetic and vagal influences on rate-dependent changes of QT interval in healthy subjects. Am J Cardiol 1991 68 : 1188 1193.
25. Cogliati C, Colombo S, Ruscone TG, Gruosso D, Porta A, Montano N, Malliani A, Furlan R : Acute beta-blockade increases muscle sympathetic activity and modifies its frequency distribution. Circulation 2004 110 : 2786 2791.
26. Iacoviello M, Massari F, De Laura D, Guida P, Mastropasqua F, Forleo C, Rizzon P, Pitzalis MV : Influence of hydrophilic and lipophilic beta-blockers on heart rate, ventricular repolarization and their interrelationship in normal subjects. Ital Heart J 2000 1 : 331 335.
27. Epstein AE, Hirschowitz BI, Kirklin JK, Kirk KA, Kay GN, Plumb VJ : Evidence for a central site of action to explain the negative chronotropic effect of atropine: Studies on the human transplanted heart. J Am Coll Cardiol 1990 15 : 1610 1617.
28. Abildskov JA : Adrenergic effects of the QT interval of the electrocardiogram. Am Heart J 1976 92 : 210 216.
29. Coghlan JG, Madden B, Norell MN, Ilsley CD, Mitchell AG : Paradoxical early lengthening and subsequent linear shortening of the QT interval in response to exercise. Eur Heart J 1992 13 : 1325 1328.
30. Oda E : Changes in QT interval during exercise testing in patients with VVI pacemakers. Pacing Clin Electrophysiol 1986 9 : 36 41.
31. Rocchetti M, Freli V, Perego V, Altomare C, Mostacciuolo G, Zaza A : Rate dependency of beta-adrenergic modulation of repolarizing currents in the guinea-pig ventricle. J Physiol 2006 574 : 183 193.
32. Karle CA, Zitron E, Zhang W, Kathofer S, Schoels W, Kiehn J : Rapid component I(Kr) of the guinea-pig cardiac delayed rectifier K(+) current is inhibited by beta(1)-adrenoreceptor activation, via cAMP/protein kinase A-dependent pathways. Cardiovasc Res 2002 53 : 355 362.
33. Heath BM, Terrar DA : Protein kinase C enhances the rapidly activating delayed rectifier potassium current, IKr, through a reduction in C-type inactivation in guinea-pig ventricular myocytes. J Physiol 2000 522 (Pt 3 391 402.
34. Thomas D, Kiehn J, Katus HA, Karle CA : Adrenergic regulation of the rapid component of the cardiac delayed rectifier potassium current, I(Kr), and the underlying hERG ion channel. Basic Res Cardiol 2004 99 : 279 287.
35. Roden DM, Lazzara R, Rosen M, Schwartz PJ, Towbin J, Vincent GM : Multiple mechanisms in the long-QT syndrome. Current knowledge, gaps, and future directions. The SADS Foundation Task Force on LQTS. Circulation 1996 94 : 1996 2012.
36. Tamargo J : Drug-induced torsade de pointes: From molecular biology to bedside. Jpn J Pharmacol 2000 83 : 1 19.
37. Zipes DP : The long QT interval syndrome. A Rosetta stone for sympathetic related ventricular tachyarrhythmias. Circulation 1991 84 : 1414 1419.
38. Xhaet O, van de Borne P, Pathak A : Dynamic ventricular repolarisation: From physiology to prognosis. Curr Cardiol Rev 2007 2 : 283 288.
39. Bayes de Luna, Coumel P, Leclercq JF : Ambulatory sudden cardiac death: Mechanisms of production of fatal arrhythmia on the basis of data from 157 cases. Am Heart J 1989 117 : 151 159.
40. Thomsen MB, Verduyn SC, Stengl M, Beekman JD, de Pater G, van Opstal J, Volders PG, Vos MA : Increased short-term variability of repolarization predicts d-sotalol-induced torsades de pointes in dogs. Circulation 2004 110 : 2453 2459.
41. Hondeghem LM : Thorough QT/QTc not so thorough: Removes torsadogenic predictors from the T-wave, incriminates safe drugs, and misses profibrillatory drugs. J Cardiovasc Electrophysiol 2006 17 : 337 340.
42. Swan H, Viitasalo M, Piippo K, Laitinen P, Kontula K, Toivonen L : Sinus node function and ventricular repolarization during exercise stress test in long QT syndrome patients with KvLQT1 and HERG potassium channel defects. J Am Coll Cardiol 1999 34 : 823 829.
43. Viitasalo M, Oikarinen L, Vaananen H, Swan H, Piippo K, Kontula K, Barron HV, Toivonen L, Scheinman MM : Differentiation between LQT1 and LQT2 patients and unaffected subjects using 24-hour electrocardiographic recordings. Am J Cardiol 2002 89 : 679 685.