Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhytmia

International Journal of Cardiology

Volumn 99, Issue 3, 2005, Pages 373-379

  Gökçe, Mustafa ^a   Karahan, Burhan ^a   Yilmaz, Remzi ^a   Örem, Cihan ^a   Erdöl, Cevdet ^a   Özdemir, Safak ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Hormone replacement therapy; QT dispersion and heart rate variability

Indexed keywords

CONJUGATED ESTROGEN; CONJUGATED ESTROGEN PLUS MEDROXYPROGESTERONE ACETATE; ESTROGEN; GESTAGEN;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTROCARDIOGRAM; ESTROGEN THERAPY; FEMALE; HEART ARRHYTHMIA; HEART RATE VARIABILITY; HEART REPOLARIZATION; HEART VENTRICLE ARRHYTHMIA; HOLTER MONITORING; HORMONE SUBSTITUTION; HUMAN; LONG TERM CARE; MENOPAUSAL SYNDROME; PARASYMPATHETIC INNERVATION; POSTMENOPAUSE; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; STATISTICAL SIGNIFICANCE; SUPRAVENTRICULAR TACHYCARDIA;

EID: 14944359671     PISSN: 01675273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijcard.2003.03.030     Document Type: Article

References (38)

1. Grodstein F., Stampfer M.J. The epidemiology of coronary heart disease and estrogen replacement therapy in postmenopausal women. Prog. Cardiovasc. Dis. 38:1995;199-210
2. Grodstein F., Stampfer M.J., Colditz G.A., et al. Postmenopausal hormone therapy and mortality. N. Engl. J. Med. 336:1997;1775-1796
3. Barrett-Conner E., Bush T.L. Estrogen and coronary heart disease in women. JAMA. 265:1991;1861-1867
4. Hulley S., Grady D., Bush T., et al. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group. JAMA. 280:(7):1998;605-613
5. Schulman S.P., Thiemann D.R., Ouyang P., et al. Effects of acute hormone therapy on recurrent ischemia in postmenopausal women with unstable angina. J. Am. Coll. Cardiol. 16;39:(2):2002;231-237
6. Higham P.D., Campbell R.W.F. QT dispersion. Br. Heart J. 71:1994;508-510
7. Han J., Goel B.G. Electrophysiologic precursors of ventricular tachyarrhythmias. Arch. Intern. Med. 129:1972;749-755
8. Kuo C.S., Munakata K., Reddy C.P., Surawicz B. Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations. Circulation. 67:1983;1356-1367
9. Yunus A., Gillis A.M, Duff H.J., et al. Increased precordial QTc dispersion predicts ventricular fibrillation during acute myocardial infarction. Am. J. Cardiol. 78:1996;706-708
10. Higham P.D., Furniss S.S., Campbell R.W. QT dispersion and components of the QT interval in ischemia and infarction. Br. Heart J. 73:1995;32-36
11. Moreno F.L., Villanueva M.T., Karagounis L.A., Anderson J.L. Coronary artery disease/myocardial infarction: reduction in QT interval dispersion by successful thrombolytic therapy in acute myocardial infarction. Circulation. 90:1994;94-100
12. Koide Y., Yotsukura M., Tajino K., Yoshino H., Ishikawa K. Use of QT dispersion measured on treadmill exercise electrocardiograms for detecting restenosis after percutaneous transluminal coronary angioplasty. Clin. Cardiol. 22:1999;639-648
13. Sbarouni E., Kremastinos T.D. Hormone replacement therapy and ventricular repolarization: the verdict is not out yet. Int. J. Card. Imaging. 75:2000;165-166
14. Liu X.K., Katchman A., Ebert S.N., Woosley R.L. The antiestrogen tamoxifen blocks the delayed rectifier potassium current, Ikr, in rabbit ventricular myocytes. J. Pharmacol. Exp. Ther. 287:1998;877-883
15. Johnson B.D., Zheng W., Korach K.S., et al. Increased expression of the cardiac L-type calcium channel in estrogen receptodeficient mice. J. Gen. Physiol. 110:1997;135-140
16. Drici M.D., Burklow T.R., Haridasse V., Glazer R.I., Woosley R.L. Sex hormones prolong the QT interval and downregulate potassium channel expression in the rabbit heart. Circulation. 94:1996;1471-1474
17. Sbarouni E., Zarvalis E., Kyriakides Z.S., Kremastinos D.T. Absence of effects of short-term estrogen replacement therapy on resting and exertional QT and QTc dispersion in postmenopausal women with coronary artery disease. Pacing Clin. Electrophysiol. 21:1998;2392-2395
18. Larsen J.A., Tung R.H., Sadananda R., et al. Effects of hormone replacement therapy on QT interval. Am. J. Cardiol. 82:1998;993-995
19. La Rovere M.T., Bigger J.T., Marcus F.I., Mortara A., Schwartz P.J. Baroreflex sensitivity and heart-rate variability in prediction total cardiac mortality after myocardial infarction. Lancet. 351:1998;478-484
20. Bigger J.T., Fleiss J.L., Steinman R.C., et al. Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation. 85:1992;164-171
21. Christ M., Seyffart K., Wehling M. Attenuation of heart-rate variability in postmenopausal women on progestin-containing hormone replacement therapy. Lancet. 353:1999;1939-1940
22. Batur M.K., Aksoyek S., Oto A., et al. Circadian variation of QTc Dispersion: Is it a clue to morning increase of sudden cardiac death? Clin. Cardiol. 22:1999;103-106
23. Lown B., Wolf M. Approaches to sudden death from coronary heart disease. Circulation. 44:1971;130-142
24. Rosano G.M., Panina G. Oestrogens and the heart. Therapie. 54:(3):1999;381-385
25. Hara M., Danilo P.J., Rosen M.R. Effects of gonadal steroids on ventricular repolarization on the response to E4031. J. Pharmacol. Exp. Ther. 285:1998;1068-1072
26. Stumpf W.E. Steroid hormones and the cardiovascular system: direct actions of estradiol, progesterone, testosterone, gluco- and mineralocorticoids and soltriol (Vitamin D) on central nervous regulatory and peripheral tissues. Experientia. 46:1990;13-25
27. Rosano G.M.C., Leonardo F., Dicandia C., et al. Acute electrophysiologic effect of estradiol 17β in menopausal women. Am. J. Cardiol. 86:2000;1385-1387
28. Rosano G.M.C., Leonardo F., Sarrel P.M., et al. Cyclical variation in paroxysmal supraventricular tachycardia in women. Lancet. 347:1996;786-788
29. Meller J., Goldman M.E. Arrhythmias in pregnancy. Gleicher N. Principles of Medical Therapy in Pregnancy. vol. 347:1988;710-725 Plenum Medical Book Company, New York
30. Lee T.M., Su S.F., Lee Y.T., Tsai C.H. Effect of estrogen on ventricular repolarization in menopausal patients with syndrome X and effects of nicorandil. Am. J. Cardiol. 84:1999;65-69
31. Haseroth K., Seyffart K., Wehling M., Christ M. Effects of progestin-estrogen replacement therapy on QT-dispersion in postmenopausal women. Int. J. Cardiol. 75:(2-3):2000;161-165
32. Yildirir A., Aybar F., Kabakci M.G., Yarali H., Akgul E., Bukulmez O., Tokgozoglu S.L., Gurgan T., Oto A. Hormone replacement therapy shortens QT dispersion in healthy postmenopausal women. Ann. Noninvasive Electrocardiol. 6:(3):2001;193-197
33. Saba S., Link M.S., Homoud M.K., et al. Effect of low estrogen states in healthy women on dispersion of ventricular repolarization. Am. J. Cardiol. 87:(3):2001;354-356
34. Mercuro G., Podda A., Pitzalis L., et al. Evidence of a role of endogenous estrogen in the modulation of autonomic nervous system. Am. J. Card. Imaging. 85:1999;787-789
35. Mercuro G., Longu G., Zoncu S., Cherchi A. Impaired forearm blood flow and vasodilator reserve in healthy postmenopausal women. Am. Heart. 137:1999;692-697
36. Owens J.F., Stoney C.M., Matthews K.A. Menopausal status influences ambulatory blood pressure levels and blood pressure changes during mental stress. Circulation. 88:1993;2794-2802
37. Saab P.G., Matthews K.A., Stoney C.M., McDonald R.H. Premenopausal and postmenopausal women differ in their cardiovascular and neuroendocrine responses to behavioral stressors. Psychophysiology. 26:1989;270-280
38. Rosano G.M., Patrizi R., Leonardo F., et al. Effect of estrogen replacement therapy on heart rate variability and heart rate in healthy postmenopausal women. Am. J. Cardiol. 80:1997;815-817