Oral Immunotherapy for Food Allergy

Immunology and Allergy Clinics of North America

Volumn 36, Issue 1, 2016, Pages 55-69

  Burbank, Allison J ^a   Sood, Puja ^c   Vickery, Brian P ^a   Wood, Robert A ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c University of Maryland Hospital for Children   (United States)

Author keywords

Desensitization; Food allergy; Immunoglobulin E (IgE); Omalizumab; Oral immunotherapy (OIT); Skin prick test (SPT); Sustained unresponsiveness; Tolerance

Indexed keywords

FOOD ALLERGEN; GAMMA INTERFERON; IMMUNOGLOBULIN E; KETOTIFEN; MONTELUKAST; OMALIZUMAB; PLACEBO; PROBIOTIC AGENT; ALLERGEN; EGG PROTEIN; MILK PROTEIN;

ABDOMINAL PAIN; ANTIGEN ANTIBODY REACTION; COHORT ANALYSIS; DESENSITIZATION; DIET RESTRICTION; DRUG EFFECT; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; DRUG TOLERABILITY; EGG ALLERGY; FOOD ALLERGY; GASTROINTESTINAL SYMPTOM; HUMAN; IMMUNOLOGICAL TOLERANCE; MILK ALLERGY; NAUSEA AND VOMITING; NONHUMAN; OPEN STUDY; ORAL IMMUNOTHERAPY; PEANUT ALLERGY; PRICK TEST; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RETROSPECTIVE STUDY; REVIEW; RHINOCONJUNCTIVITIS; SKIN TEST; TREATMENT RESPONSE; URTICARIA; VOMITING; WHEEZING; ANIMAL; ARACHIS; BOVINE; FOOD HYPERSENSITIVITY; IMMUNOLOGY; ORAL DRUG ADMINISTRATION;

ADMINISTRATION, ORAL; ALLERGENS; ANIMALS; ARACHIS; CATTLE; DESENSITIZATION, IMMUNOLOGIC; EGG PROTEINS; FOOD HYPERSENSITIVITY; HUMANS; MILK PROTEINS;

EID: 84947996581     PISSN: 08898561     EISSN: 15578607     Source Type: Journal    
DOI: 10.1016/j.iac.2015.08.007     Document Type: Review

References (68)

1. Gupta R.S., Springston E.E., Warrier M.R., et al. The prevalence, severity, and distribution of childhood food allergy in the United States. Pediatrics 2011, 128(1):e9-e17.
2. Chafen J.J., Newberry S.J., Riedl M.A., et al. Diagnosing and managing common food allergies: a systematic review. JAMA 2010, 303(18):1848-1856.
3. Kim J., Kwon J., Noh G., et al. The effects of elimination diet on nutritional status in subjects with atopic dermatitis. Nutr Res Pract 2013, 7(6):488-494.
4. Hobbs C.B., Skinner A.C., Burks A.W., et al. Food allergies affect growth in children. J Allergy Clin Immunol Pract 2015, 3(1):133-134.e1.
5. Nowak-Wegrzyn A., Sampson H.A. Future therapies for food allergies. J Allergy Clin Immunol 2011, 127(3):558-573. [quiz 574-5].
6. Nurmatov U., Venderbosch I., Devereux G., et al. Allergen-specific oral immunotherapy for peanut allergy. Cochrane Database Syst Rev 2012, (9). CD009014.
7. Sicherer S.H., Sampson H.A. Food allergy. J Allergy Clin Immunol 2010, 125(2 Suppl 2):S116-S125.
8. Bock S.A., Munoz-Furlong A., Sampson H.A. Further fatalities caused by anaphylactic reactions to food, 2001-2006. J Allergy Clin Immunol 2007, 119(4):1016-1018.
9. Wensing M., Penninks A.H., Hefle S.L., et al. The range of minimum provoking doses in hazelnut-allergic patients as determined by double-blind, placebo-controlled food challenges. Clin Exp Allergy 2002, 32(12):1757-1762.
10. Sampson M.A., Munoz-Furlong A., Sicherer S.H. Risk-taking and coping strategies of adolescents and young adults with food allergy. J Allergy Clin Immunol 2006, 117(6):1440-1445.
11. Bock S.A., Munoz-Furlong A., Sampson H.A. Fatalities due to anaphylactic reactions to foods. J Allergy Clin Immunol 2001, 107(1):191-193.
12. Nguyen-Luu N.U., Ben-Shoshan M., Alizadehfar R., et al. Inadvertent exposures in children with peanut allergy. Pediatr Allergy Immunol 2012, 23(2):133-139.
13. Lieberman J.A., Sicherer S.H. Quality of life in food allergy. Curr Opin Allergy Clin Immunol 2011, 11(3):236-242.
14. Hofmann A., Scurlock A.M., Jones S.M., et al. Safety of a peanut oral immunotherapy protocol in children with peanut allergy. J Allergy Clin Immunol 2009, 124(2):286-291. 291.e1-6.
15. Kulis M., Wright B.L., Jones S.M., et al. Diagnosis, management, and investigational therapies for food allergies. Gastroenterology 2015, 148(6):1132-1142.
16. Burks A.W., Jones S.M., Wood R.A., et al. Oral immunotherapy for treatment of egg allergy in children. N Engl J Med 2012, 367(3):233-243.
17. Vickery B.P., Scurlock A.M., Kulis M., et al. Sustained unresponsiveness to peanut in subjects who have completed peanut oral immunotherapy. J Allergy Clin Immunol 2014, 133(2):468-475.
18. Staden U., Rolinck-Werninghaus C., Brewe F., et al. Specific oral tolerance induction in food allergy in children: efficacy and clinical patterns of reaction. Allergy 2007, 62(11):1261-1269.
19. Blumchen K., Ulbricht H., Staden U., et al. Oral peanut immunotherapy in children with peanut anaphylaxis. J Allergy Clin Immunol 2010, 126(1):83-91.e1.
20. Keet C.A., Seopaul S., Knorr S., et al. Long-term follow-up of oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2013, 132(3):737-739.e6.
21. Gorelik M., Narisety S.D., Guerrerio A.L., et al. Suppression of the immunologic response to peanut during immunotherapy is often transient. J Allergy Clin Immunol 2015, 135(5):1283-1292.
22. Caminiti L., Pajno G.B., Crisafulli G., et al. oral immunotherapy for egg allergy: a double-blind placebo-controlled study, with postdesensitization follow-up. J Allergy Clin Immunol Pract 2015, 3(4):532-539.
23. Oppenheimer J.J., Nelson H.S., Bock S.A., et al. Treatment of peanut allergy with rush immunotherapy. J Allergy Clin Immunol 1992, 90(2):256-262.
24. Patriarca G., Nucera E., Pollastrini E., et al. Oral rush desensitization in peanut allergy: a case report. Dig Dis Sci 2006, 51(3):471-473.
25. Mansfield L. Successful oral desensitization for systemic peanut allergy. Ann Allergy Asthma Immunol 2006, 97(2):266-267.
26. Jones S.M., Pons L., Roberts J.L., et al. Clinical efficacy and immune regulation with peanut oral immunotherapy. J Allergy Clin Immunol 2009, 124(2):292-300. 300.e1-97.
27. Varshney P., Jones S.M., Scurlock A.M., et al. A randomized controlled study of peanut oral immunotherapy: clinical desensitization and modulation of the allergic response. J Allergy Clin Immunol 2011, 127(3):654-660.
28. Anagnostou K., Jones S.M., Scurlock A.M., et al. Efficacy and safety of high-dose peanut oral immunotherapy with factors predicting outcome. Clin Exp Allergy 2011, 41(9):1273-1281.
29. Anagnostou K., Islam S., King Y., et al. Assessing the efficacy of oral immunotherapy for the desensitisation of peanut allergy in children (STOP II): a phase 2 randomised controlled trial. Lancet 2014, 383(9925):1297-1304.
30. Narisety S.D., Frischmeyer-Guerrerio P.A., Keet C.A., et al. A randomized, double-blind, placebo-controlled pilot study of sublingual versus oral immunotherapy for the treatment of peanut allergy. J Allergy Clin Immunol 2014, 135(5):1275-1282.e1-6.
31. Patriarca G., Nucera E., Roncallo C., et al. Oral desensitizing treatment in food allergy: clinical and immunological results. Aliment Pharmacol Ther 2003, 17(3):459-465.
32. Patriarca G., Nucera E., Roncallo C., et al. Food allergy in children: results of a standardized protocol for oral desensitization. Hepatogastroenterology 1998, 45(19):52-58.
33. Buchanan A.D., Green T.D., Jones S.M., et al. Egg oral immunotherapy in nonanaphylactic children with egg allergy. J Allergy Clin Immunol 2007, 119(1):199-205.
34. Vickery B.P., Pons L., Kulis M., et al. Individualized IgE-based dosing of egg oral immunotherapy and the development of tolerance. Ann Allergy Asthma Immunol 2010, 105(6):444-450.
35. Morisset M., Moneret-Vautrin D.A., Guenard L., et al. Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow's milk allergy and 90 children with egg allergy. Eur Ann Allergy Clin Immunol 2007, 39(1):12-19.
36. Dello Iacono I., Tripodi S., Calvani M., et al. Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: a randomized controlled trial. Pediatr Allergy Immunol 2013, 24(1):66-74.
37. Meglio P., Giampietro P.G., Carello R., et al. Oral food desensitization in children with IgE-mediated hen's egg allergy: a new protocol with raw hen's egg. Pediatr Allergy Immunol 2013, 24(1):75-83.
38. Itoh N., Itagaki Y., Kurihara K. Rush specific oral tolerance induction in school-age children with severe egg allergy: one year follow up. Allergol Int 2010, 59(1):43-51.
39. Garcia Rodriguez R., Urra J.M., Feo-Brito F., et al. Oral rush desensitization to egg: efficacy and safety. Clin Exp Allergy 2011, 41(9):1289-1296.
40. Meglio P., Bartone E., Plantamura M., et al. A protocol for oral desensitization in children with IgE-mediated cow's milk allergy. Allergy 2004, 59(9):980-987.
41. Meglio P., Giampietro P.G., Gianni S., et al. Oral desensitization in children with immunoglobulin E-mediated cow's milk allergy-follow-up at 4 yr and 8 months. Pediatr Allergy Immunol 2008, 19(5):412-419.
42. Zapatero L., Alonso E., Fuentes V., et al. Oral desensitization in children with cow's milk allergy. J Investig Allergol Clin Immunol 2008, 18(5):389-396.
43. Alvaro M., Giner M.T., Vázquez M., et al. Specific oral desensitization in children with IgE-mediated cow's milk allergy. Evolution in one year. Eur J Pediatr 2012, 171(9):1389-1395.
44. Sanchez-Garcia S., Rodríguez del Río P., Escudero C., et al. Efficacy of oral immunotherapy protocol for specific oral tolerance induction in children with cow's milk allergy. Isr Med Assoc J 2012, 14(1):43-47.
45. Longo G., Barbi E., Berti I., et al. Specific oral tolerance induction in children with very severe cow's milk-induced reactions. J Allergy Clin Immunol 2008, 121(2):343-347.
46. Skripak J.M., Nash S.D., Rowley H., et al. A randomized, double-blind, placebo-controlled study of milk oral immunotherapy for cow's milk allergy. J Allergy Clin Immunol 2008, 122(6):1154-1160.
47. Narisety S.D., Skripak J.M., Steele P., et al. Open-label maintenance after milk oral immunotherapy for IgE-mediated cow's milk allergy. J Allergy Clin Immunol 2009, 124(3):610-612.
48. Pajno G.B., Caminiti L., Ruggeri P., et al. Oral immunotherapy for cow's milk allergy with a weekly up-dosing regimen: a randomized single-blind controlled study. Ann Allergy Asthma Immunol 2010, 105(5):376-381.
49. Pajno G.B., Caminiti L., Salzano G., et al. Comparison between two maintenance feeding regimens after successful cow's milk oral desensitization. Pediatr Allergy Immunol 2013, 24(4):376-381.
50. Martorell A., De la Hoz B., Ibáñez M.D., et al. Oral desensitization as a useful treatment in 2-year-old children with cow's milk allergy. Clin Exp Allergy 2011, 41(9):1297-1304.
51. Salmivesi S., Korppi M., Mäkelä M.J., et al. Milk oral immunotherapy is effective in school-aged children. Acta Paediatr 2013, 102(2):172-176.
52. Keet C.A., Frischmeyer-Guerrerio P.A., Thyagarajan A., et al. The safety and efficacy of sublingual and oral immunotherapy for milk allergy. J Allergy Clin Immunol 2012, 129(2):448-455. 455.e1-5.
53. Begin P., Winterroth L.C., Dominguez T., et al. Safety and feasibility of oral immunotherapy to multiple allergens for food allergy. Allergy Asthma Clin Immunol 2014, 10(1):1.
54. Vickery B.P., Lin J., Kulis M., et al. Peanut oral immunotherapy modifies IgE and IgG4 responses to major peanut allergens. J Allergy Clin Immunol 2013, 131(1):128-134.e1-3.
55. Syed A., Garcia M.A., Lyu S.C., et al. Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3). J Allergy Clin Immunol 2014, 133(2):500-510.
56. Chen Y., Inobe J., Marks R., et al. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature 1995, 376(6536):177-180.
57. Begin P., Nadeau K.C. Changes in peanut-specific T-cell clonotype with oral immunotherapy. J Allergy Clin Immunol 2015, 135(6):1636-1638.e3.
58. Wasserman R.L., Factor J.M., Baker J.W., et al. Oral immunotherapy for peanut allergy: multipractice experience with epinephrine-treated reactions. J Allergy Clin Immunol Pract 2014, 2(1):91-96.
59. Sanchez-Garcia S., Rodríguez Del Río P., Escudero C., et al. Possible eosinophilic esophagitis induced by milk oral immunotherapy. J Allergy Clin Immunol 2012, 129(4):1155-1157.
60. Ridolo E., De Angelis G.L., Dall'aglio P. Eosinophilic esophagitis after specific oral tolerance induction for egg protein. Ann Allergy Asthma Immunol 2011, 106(1):73-74.
61. Lucendo A.J., Arias A., Tenias J.M. Relation between eosinophilic esophagitis and oral immunotherapy for food allergy: a systematic review with meta-analysis. Ann Allergy Asthma Immunol 2014, 113(6):624-629.
62. Nadeau K.C., Schneider L.C., Hoyte L., et al. Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. J Allergy Clin Immunol 2011, 127(6):1622-1624.
63. Schneider L.C., Rachid R., LeBovidge J., et al. A pilot study of omalizumab to facilitate rapid oral desensitization in high-risk peanut-allergic patients. J Allergy Clin Immunol 2013, 132(6):1368-1374.
64. Tang M.L., Ponsonby A.L., Orsini F., et al. Administration of a probiotic with peanut oral immunotherapy: a randomized trial. J Allergy Clin Immunol 2015, 135(3):737-744.e8.
65. Noh G., Lee S.S. A pilot study of interferon-gamma-induced specific oral tolerance induction (ISOTI) for immunoglobulin E-mediated anaphylactic food allergy. J Interferon Cytokine Res 2009, 29(10):667-675.
66. Jagdis A., Berlin N., Barron C., et al. Effect of ketotifen premedication on adverse reactions during peanut oral immunotherapy. Allergy Asthma Clin Immunol 2014, 10(1):36.
67. Takahashi M., Taniuchi S., Soejima K., et al. New efficacy of LTRAs (montelukast sodium): it possibly prevents food-induced abdominal symptoms during oral immunotherapy. Allergy Asthma Clin Immunol 2014, 10(1):3.
68. Lee S.J., Noh G., Lee J.H. In vitro induction of allergen-specific interleukin-10-producing regulatory b cell responses by interferon-gamma in non-immunoglobulin e-mediated milk allergy. Allergy Asthma Immunol Res 2013, 5(1):48-54.