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Volumn 10, Issue 9, 2015, Pages

Investigating the mechanism of hyperglycemia-induced fetal cardiac hypertrophy

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 10; CONNEXIN 43; GLUCOSE; MYOSIN HEAVY CHAIN BETA; POTASSIUM CHANNEL KCNE1; STREPTOZOCIN; TRANSCRIPTION FACTOR NKX2.5; UNCLASSIFIED DRUG; GLUCOSE BLOOD LEVEL; HOMEOBOX PROTEIN NKX-2.5; HOMEODOMAIN PROTEIN; NKX2-5 PROTEIN, MOUSE; TRANSCRIPTION FACTOR;

EID: 84947976486     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0139141     Document Type: Article
Times cited : (51)

References (37)
  • 1
    • 84861131933 scopus 로고    scopus 로고
    • Influence of maternal metabolism and parental genetics on fetal maldevelopment in diabetic rat pregnancy
    • PMID: 22374754
    • Ejdesjo A, Wentzel P, Eriksson UJ. Influence of maternal metabolism and parental genetics on fetal maldevelopment in diabetic rat pregnancy. Am J Physiol-Endoc M. 2012; 302(10):E1198-209. doi: 10.1152/ajpendo.00661.2011 PMID: 22374754.
    • (2012) Am J Physiol-Endoc M. , vol.302 , Issue.10 , pp. E1198-E11209
    • Ejdesjo, A.1    Wentzel, P.2    Eriksson, U.J.3
  • 2
    • 84858168254 scopus 로고    scopus 로고
    • Importance of early complex evaluation in high-risk pregnancy associated to diabetes mellitus. Case presentation and review of the literature
    • PMID: 22119836
    • Gheorman L, Iliescu D, Ceausu I, Paulescu D, Plesea IE, Gheorman V. Importance of early complex evaluation in high-risk pregnancy associated to diabetes mellitus. Case presentation and review of the literature. Rom J Morphol Embryo. 2011; 52(3 Suppl):1127-32. PMID: 22119836.
    • (2011) Rom J Morphol Embryo. , vol.52 , Issue.3 , pp. 1127-1132
    • Gheorman, L.1    Iliescu, D.2    Ceausu, I.3    Paulescu, D.4    Plesea, I.E.5    Gheorman, V.6
  • 3
    • 84921391797 scopus 로고    scopus 로고
    • Diabetes and congenital heart defects: A systematic review, meta-analysis, and modeling project
    • PMID: 25326416
    • Simeone RM, Devine OJ, Marcinkevage JA, Gilboa SM, Razzaghi H, Bardenheier BH, et al. Diabetes and congenital heart defects: a systematic review, meta-analysis, and modeling project. Am J Prev Med. 2015; 48(2):195-204. doi: 10.1016/j.amepre.2014.09.002 PMID: 25326416.
    • (2015) Am J Prev Med. , vol.48 , Issue.2 , pp. 195-204
    • Simeone, R.M.1    Devine, O.J.2    Marcinkevage, J.A.3    Gilboa, S.M.4    Razzaghi, H.5    Bardenheier, B.H.6
  • 4
    • 84864392621 scopus 로고    scopus 로고
    • Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy
    • PMID: 22688338
    • Li X, Weng H, Xu C, Reece EA, Yang P. Oxidative stress-induced JNK1/2 activation triggers proapoptotic signaling and apoptosis that leads to diabetic embryopathy. Diabetes. 2012; 61(8):2084-92. doi: 10.2337/db11-1624 PMID: 22688338.
    • (2012) Diabetes , vol.61 , Issue.8 , pp. 2084-2092
    • Li, X.1    Weng, H.2    Xu, C.3    Reece, E.A.4    Yang, P.5
  • 5
    • 0036821884 scopus 로고    scopus 로고
    • The role of reactive oxygen species in diabetes-induced anomalies in embryos of cohen diabetic rats
    • PMID: 12546278
    • Zangen SW, Yaffe P, Shechtman S, Zangen DH, Ornoy A. The role of reactive oxygen species in diabetes-induced anomalies in embryos of Cohen diabetic rats. Int J Exp Diabetes Res. 2002; 3(4):247-55. doi: 10.1080/15604280214933 PMID: 12546278.
    • (2002) Int J Exp Diabetes Res. , vol.3 , Issue.4 , pp. 247-255
    • Zangen, S.W.1    Yaffe, P.2    Shechtman, S.3    Zangen, D.H.4    Ornoy, A.5
  • 6
    • 84884128344 scopus 로고    scopus 로고
    • High glucose level induces cardiovascular dysplasia during early embryo development
    • PMID: 23864493
    • Jin YM, Zhao SZ, Zhang ZL, Chen Y, Cheng X, Chuai M, et al. High glucose level induces cardiovascular dysplasia during early embryo development. Exp Clin Endocr Diab. 2013; 121(8):448-54. doi: 10.1055/s-0033-1349080 PMID: 23864493.
    • (2013) Exp Clin Endocr Diab. , vol.121 , Issue.8 , pp. 448-454
    • Jin, Y.M.1    Zhao, S.Z.2    Zhang, Z.L.3    Chen, Y.4    Cheng, X.5    Chuai, M.6
  • 7
    • 67649303368 scopus 로고    scopus 로고
    • Fetal cardiac effects of maternal hyperglycemia during pregnancy
    • PMID: 19180650
    • Corrigan N, Brazil DP, McAuliffe F. Fetal cardiac effects of maternal hyperglycemia during pregnancy. Birth Defects Res A Clin Mol Teratol. 2009; 85(6):523-30. doi: 10.1002/bdra.20567 PMID: 19180650.
    • (2009) Birth Defects Res a Clin Mol Teratol. , vol.85 , Issue.6 , pp. 523-530
    • Corrigan, N.1    Brazil, D.P.2    McAuliffe, F.3
  • 8
    • 84880850374 scopus 로고    scopus 로고
    • O-glcnacylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2
    • PMID: 23665912
    • Ding F, Yu L, Wang M, Xu S, Xia Q, Fu G. O-GlcNAcylation involvement in high glucose-induced cardiac hypertrophy via ERK1/2 and cyclin D2. Amino Acids. 2013; 45(2):339-49. doi: 10.1007/s00726-013-1504-2 PMID: 23665912.
    • (2013) Amino Acids , vol.45 , Issue.2 , pp. 339-349
    • Ding, F.1    Yu, L.2    Wang, M.3    Xu, S.4    Xia, Q.5    Fu, G.6
  • 9
    • 84862543941 scopus 로고    scopus 로고
    • Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in thedb/db mouse model of type 2 diabetes
    • PMID: 22374176
    • Huynh K, Kiriazis H, Du XJ, Love JE, Jandeleit-Dahm KA, Forbes JM, et al. Coenzyme Q10 attenuates diastolic dysfunction, cardiomyocyte hypertrophy and cardiac fibrosis in thedb/db mouse model of type 2 diabetes. Diabetologia. 2012; 55(5):1544-53. doi: 10.1007/s00125-012-2495-3 PMID: 22374176.
    • (2012) Diabetologia , vol.55 , Issue.5 , pp. 1544-1553
    • Huynh, K.1    Kiriazis, H.2    Du, X.J.3    Love, J.E.4    Jandeleit-Dahm, K.A.5    Forbes, J.M.6
  • 10
    • 22244485655 scopus 로고    scopus 로고
    • Reference guide to the stages of chick heart embryology
    • PMID: 15986452
    • Martinsen BJ. Reference guide to the stages of chick heart embryology. Developmental Dynamics. 2005; 233(4):1217-37. doi: 10.1002/Dvdy.20468 PMID: 15986452.
    • (2005) Developmental Dynamics , vol.233 , Issue.4 , pp. 1217-1237
    • Martinsen, B.J.1
  • 11
    • 4043059202 scopus 로고    scopus 로고
    • Right ventricular myocardium derives from the anterior heart field
    • PMID: 15217909
    • Zaffran S, Kelly RG, Meilhac SM, Buckingham ME, Brown NA. Right ventricular myocardium derives from the anterior heart field. Circ Res. 2004; 95(3):261-8. doi: 10.1161/01.RES.0000136815.73623.BE PMID: 15217909.
    • (2004) Circ Res. , vol.95 , Issue.3 , pp. 261-268
    • Zaffran, S.1    Kelly, R.G.2    Meilhac, S.M.3    Buckingham, M.E.4    Brown, N.A.5
  • 12
    • 0029845996 scopus 로고    scopus 로고
    • Heartless, aDrosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages
    • PMID: 8957000
    • Beiman M, Shilo BZ, Volk T. Heartless, aDrosophila FGF receptor homolog, is essential for cell migration and establishment of several mesodermal lineages. Genes Dev. 1996; 10(23):2993-3002.doi: 10.1101/gad.10.23.2993 PMID: 8957000.
    • (1996) Genes Dev. , vol.10 , Issue.23 , pp. 2993-3002
    • Beiman, M.1    Shilo, B.Z.2    Volk, T.3
  • 13
    • 0036746709 scopus 로고    scopus 로고
    • Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8
    • PMID: 12361604
    • Yang X, Dormann D, Munsterberg AE, Weijer CJ. Cell movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8. Dev Cell. 2002; 3(3):425-37. doi: 10.1016/S1534-5807(02)00256-3 PMID: 12361604.
    • (2002) Dev Cell. , vol.3 , Issue.3 , pp. 425-437
    • Yang, X.1    Dormann, D.2    Munsterberg, A.E.3    Weijer, C.J.4
  • 14
    • 0038485530 scopus 로고    scopus 로고
    • Heart development: Molecular insights into cardiac specification and early morphogenesis
    • PMID: 12781678
    • Brand T. Heart development: molecular insights into cardiac specification and early morphogenesis. Dev Biol. 2003; 258(1):1-19. doi: 10.1016/S0012-1606(03)00112-X PMID: 12781678.
    • (2003) Dev Biol. , vol.258 , Issue.1 , pp. 1-19
    • Brand, T.1
  • 15
    • 38049183155 scopus 로고    scopus 로고
    • Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular development
    • PMID: 17967198
    • Kumar SD, Dheen ST, Tay SSW. Maternal diabetes induces congenital heart defects in mice by altering the expression of genes involved in cardiovascular development. Cardiovasc Diabetol. 2007; 6:34. doi: 10.1186/1475-2840-6-34 PMID: 17967198.
    • (2007) Cardiovasc Diabetol. , vol.6 , pp. 34
    • Kumar, S.D.1    Dheen, S.T.2    Tay, S.S.W.3
  • 16
    • 84867336675 scopus 로고    scopus 로고
    • Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice
    • PMID: 22819979
    • Kumar SD, Vijaya M, Samy RP, Dheen ST, Ren M, Watt F, et al. Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice. Free Radical Bio Med. 2012; 53(8):1595-606. doi: 10.1016/j.freeradbiomed.2012.07.008 PMID: 22819979.
    • (2012) Free Radical Bio Med. , vol.53 , Issue.8 , pp. 1595-1606
    • Kumar, S.D.1    Vijaya, M.2    Samy, R.P.3    Dheen, S.T.4    Ren, M.5    Watt, F.6
  • 17
    • 84906313796 scopus 로고    scopus 로고
    • Excess ROS induced byAAPH causes myocardial hypertrophy in the developing chick embryo
    • PMID: 25037699
    • Li Y, Wang XY, Zhang ZL, Cheng X, Li XD, Chuai ML, et al. Excess ROS induced byAAPH causes myocardial hypertrophy in the developing chick embryo. Int J Cardiol. 2014; 176(1):62-73. doi: 10.1016/j.ijcard.2014.06.044 PMID: 25037699.
    • (2014) Int J Cardiol. , vol.176 , Issue.1 , pp. 62-73
    • Li, Y.1    Wang, X.Y.2    Zhang, Z.L.3    Cheng, X.4    Li, X.D.5    Chuai, M.L.6
  • 18
    • 84947964611 scopus 로고
    • The ultrasonic cardiogram measurement of 909 normal full-term infants and children
    • Qin RJ. The Ultrasonic cardiogram measurement of 909 normal full-term infants and children. Zhonghua Er KeZaZhi (chinese). 1981; 19(2):92-5.
    • (1981) Zhonghua Er KeZaZhi (Chinese) , vol.19 , Issue.2 , pp. 92-95
    • Qin, R.J.1
  • 19
    • 84904733302 scopus 로고    scopus 로고
    • Propofol ameliorates hyperglycemia-induced cardiac hypertrophy and dysfunction via heme oxygenase-1/Signal transducer and activator of transcription 3 signaling pathway in rats
    • PMID: 24810525
    • Xu JJ, Li HB, Irwin MG, Xia ZY, Mao XW, Lei SQ, et al. Propofol Ameliorates Hyperglycemia-Induced Cardiac Hypertrophy and Dysfunction via Heme Oxygenase-1/Signal Transducer and Activator of Transcription 3 Signaling Pathway in Rats. Crit Care Med. 2014; 42(8):E583-E94. doi: 10.1097/Ccm.0000000000000415 PMID: 24810525.
    • (2014) Crit Care Med. , vol.42 , Issue.8 , pp. E583-E594
    • Xu, J.J.1    Li, H.B.2    Irwin, M.G.3    Xia, Z.Y.4    Mao, X.W.5    Lei, S.Q.6
  • 20
    • 0032907924 scopus 로고    scopus 로고
    • The cardiac homeobox gene csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development
    • PMID: 10021345
    • Tanaka M, Chen Z, Bartunkova S, Yamasaki N, Izumo S. The cardiac homeobox gene Csx/Nkx2.5 lies genetically upstream of multiple genes essential for heart development. Development. 1999; 126(6):1269-80. PMID: 10021345.
    • (1999) Development , vol.126 , Issue.6 , pp. 1269-1280
    • Tanaka, M.1    Chen, Z.2    Bartunkova, S.3    Yamasaki, N.4    Izumo, S.5
  • 21
    • 84897572490 scopus 로고    scopus 로고
    • Mesodermal nkx2.5 is necessary and sufficient for early second heart field development
    • PMID: 24613616
    • Zhang L, Nomura-Kitabayashi A, Sultana N, Cai WB, Cai XQ, Moon AM, et al. Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development. Dev Biol. 2014; 390(1):68-79. doi: 10.1016/j.ydbio.2014.02.023 PMID: 24613616.
    • (2014) Dev Biol. , vol.390 , Issue.1 , pp. 68-79
    • Zhang, L.1    Nomura-Kitabayashi, A.2    Sultana, N.3    Cai, W.B.4    Cai, X.Q.5    Moon, A.M.6
  • 22
    • 0347989434 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy: An important global disease
    • PMID: 14706671
    • Maron BJ. Hypertrophic cardiomyopathy: An important global disease. Am J Med. 2004; 116(1):63-5. doi: 10.1016/j.amjmed.2003.10.012 PMID: 14706671.
    • (2004) Am J Med. , vol.116 , Issue.1 , pp. 63-65
    • Maron, B.J.1
  • 23
    • 76649106709 scopus 로고    scopus 로고
    • Contemporary insights and strategies for risk stratification and prevention of sudden death in hypertrophic cardiomyopathy
    • PMID: 20100987
    • Maron BJ. Contemporary Insights and Strategies for Risk Stratification and Prevention of Sudden Death in Hypertrophic Cardiomyopathy. Circulation. 2010; 121(3):445-56. doi: 10.1161/Circulationaha.109.878579 PMID: 20100987.
    • (2010) Circulation , vol.121 , Issue.3 , pp. 445-456
    • Maron, B.J.1
  • 24
    • 37549040201 scopus 로고    scopus 로고
    • Genetic basis of hypertrophic cardiomyopathy: From bench to the clinics
    • PMID: 17916152
    • Alcalai R, Seidman JG, Seidman CE. Genetic basis of hypertrophic cardiomyopathy: From bench to the clinics. J Cardiovasc Electr. 2008; 19(1):104-10. doi: 10.1111/j.1540-8167.2007.00965.x PMID: 17916152.
    • (2008) J Cardiovasc Electr. , vol.19 , Issue.1 , pp. 104-110
    • Alcalai, R.1    Seidman, J.G.2    Seidman, C.E.3
  • 25
    • 0025280867 scopus 로고
    • Prognostic implications of echocardiographically determined left ventricular mass in the framingham heart study
    • PMID: 2139921
    • Levy D, Garrison RJ, Savage DD, Kannel WB, Castelli WP. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham Heart Study. New Engl J Med. 1990; 322(22):1561-6. doi: 10.1056/NEJM199005313222203 PMID: 2139921.
    • (1990) New Engl J Med. , vol.322 , Issue.22 , pp. 1561-1566
    • Levy, D.1    Garrison, R.J.2    Savage, D.D.3    Kannel, W.B.4    Castelli, W.P.5
  • 26
    • 84878885458 scopus 로고    scopus 로고
    • Cardiomyopathy and diastolic dysfunction in the embryo and neonate of a type 1 diabetic mouse model
    • PMID: 23269095
    • Corrigan N, Treacy A, Brazil DP, McAuliffe FM. Cardiomyopathy and diastolic dysfunction in the embryo and neonate of a type 1 diabetic mouse model. Reprod Sci. 2013; 20(7):781-90. doi: 10.1177/1933719112466298 PMID: 23269095.
    • (2013) Reprod Sci. , vol.20 , Issue.7 , pp. 781-790
    • Corrigan, N.1    Treacy, A.2    Brazil, D.P.3    McAuliffe, F.M.4
  • 27
    • 34547185623 scopus 로고    scopus 로고
    • Oxidative stress and redox signalling in cardiac hypertrophy and heart failure
    • PMID: 16670100
    • Seddon M, Looi YH, Shah AM. Oxidative stress and redox signalling in cardiac hypertrophy and heart failure. Heart. 2007; 93(8):903-7. doi: 10.1136/hrt.2005.068270 PMID: 16670100.
    • (2007) Heart , vol.93 , Issue.8 , pp. 903-907
    • Seddon, M.1    Looi, Y.H.2    Shah, A.M.3
  • 28
    • 79952846864 scopus 로고    scopus 로고
    • Increased fat mass and cardiac septal hypertrophy in newborn infants of mothers with well-controlled diabetes during pregnancy
    • PMID: 21430391
    • Aman J, Hansson U, Ostlund I, Wall K, Persson B. Increased fat mass and cardiac septal hypertrophy in newborn infants of mothers with well-controlled diabetes during pregnancy. Neonatology. 2011; 100(2):147-54. doi: 10.1159/000323741 PMID: 21430391.
    • (2011) Neonatology , vol.100 , Issue.2 , pp. 147-154
    • Aman, J.1    Hansson, U.2    Ostlund, I.3    Wall, K.4    Persson, B.5
  • 29
    • 0015357365 scopus 로고
    • Myosin synthesis and degradation during development of cardiac hypertrophy in the rabbit
    • PMID: 4260249
    • Morkin E, Kimata S, Skillman JJ. Myosin synthesis and degradation during development of cardiac hypertrophy in the rabbit. Circ Res. 1972; 30(6):690-702. PMID: 4260249.
    • (1972) Circ Res. , vol.30 , Issue.6 , pp. 690-702
    • Morkin, E.1    Kimata, S.2    Skillman, J.J.3
  • 30
    • 78449306063 scopus 로고    scopus 로고
    • Effect of U50,488H, a kappa-opioid receptor agonist on myocardial alpha-and beta-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced cardiac hypertrophy in rat
    • PMID: 20730476
    • Jaiswal A, Kumar S, Seth S, Dinda AK, Maulik SK. Effect of U50,488H, a kappa-opioid receptor agonist on myocardial alpha-and beta-myosin heavy chain expression and oxidative stress associated with isoproterenol-induced cardiac hypertrophy in rat. Mol Cell Biochem. 2010; 345(1-2):231-40. doi: 10.1007/s11010-010-0577-4 PMID: 20730476.
    • (2010) Mol Cell Biochem. , vol.345 , Issue.1-2 , pp. 231-240
    • Jaiswal, A.1    Kumar, S.2    Seth, S.3    Dinda, A.K.4    Maulik, S.K.5
  • 31
    • 84867145472 scopus 로고    scopus 로고
    • Myocardin regulates BMP10 expression and is required for heart development
    • PMID: 22996691
    • Huang J, Elicker J, Bowens N, Liu X, Cheng L, Cappola TP, et al. Myocardin regulates BMP10 expression and is required for heart development. J Clin Invest. 2012; 122(10):3678-91. doi: 10.1172/JCI63635 PMID: 22996691.
    • (2012) J Clin Invest. , vol.122 , Issue.10 , pp. 3678-3691
    • Huang, J.1    Elicker, J.2    Bowens, N.3    Liu, X.4    Cheng, L.5    Cappola, T.P.6
  • 32
    • 11144357335 scopus 로고    scopus 로고
    • Nkx2-5 pathways and congenital heart disease: Loss of ventricular myocyte lineage progressive cardiomyopathy and complete heart block
    • PMID: 15109497
    • Pashmforoush M, Lu JT, Chen HY, St Amand T, Kondo R, Pradervand S, et al. Nkx2-5 pathways and congenital heart disease: Loss of ventricular myocyte lineage progressive cardiomyopathy and complete heart block. Cell. 2004; 117(3):373-86. doi: 10.1016/S0092-8674(04)00405-2 PMID: 15109497.
    • (2004) Cell. , vol.117 , Issue.3 , pp. 373-386
    • Pashmforoush, M.1    Lu, J.T.2    Chen, H.Y.3    St Amand, T.4    Kondo, R.5    Pradervand, S.6
  • 33
    • 33751396373 scopus 로고    scopus 로고
    • Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo
    • PMID: 17140938
    • Azakie A, Fineman JR, He YP. Myocardial transcription factors are modulated during pathologic cardiac hypertrophy in vivo. J Thorac Cardiov Sur. 2006; 132(6):1262-U6. doi: 10.1016/j.jtcvs.2006.08. 005 PMID: 17140938.
    • (2006) J Thorac Cardiov Sur. , vol.132 , Issue.6 , pp. 1262-1266
    • Azakie, A.1    Fineman, J.R.2    He, Y.P.3
  • 34
    • 79959962188 scopus 로고    scopus 로고
    • Ablation of nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation
    • PMID: 21285290
    • Terada R, Warren S, Lu JT, Chien KR, Wessels A, Kasahara H. Ablation of Nkx2-5 at mid-embryonic stage results in premature lethality and cardiac malformation. Cardiovasc Res. 2011; 91(2):289-99. doi: 10.1093/cvr/cvr037 PMID: 21285290.
    • (2011) Cardiovasc Res. , vol.91 , Issue.2 , pp. 289-299
    • Terada, R.1    Warren, S.2    Lu, J.T.3    Chien, K.R.4    Wessels, A.5    Kasahara, H.6
  • 35
    • 84861625028 scopus 로고    scopus 로고
    • Gene regulatory networks in cardiac conduction system development
    • PMID: 22628576
    • Munshi NV. Gene Regulatory Networks in Cardiac Conduction System Development. Circ Res. 2012; 110(11):1525-37. doi: 10.1161/Circresaha.111.260026 PMID: 22628576.
    • (2012) Circ Res. , vol.110 , Issue.11 , pp. 1525-1537
    • Munshi, N.V.1
  • 36
    • 21344435944 scopus 로고    scopus 로고
    • Cardiac transcription factor csx/Nkx2-5: Its role in cardiac development and diseases
    • PMID: 15925411
    • Akazawa H, Komuro I. Cardiac transcription factor Csx/Nkx2-5: its role in cardiac development and diseases. Pharmacol therapeut. 2005; 107(2):252-68. doi: 10.1016/j.pharmthera.2005.03.005 PMID: 15925411.
    • (2005) Pharmacol Therapeut. , vol.107 , Issue.2 , pp. 252-268
    • Akazawa, H.1    Komuro, I.2


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