Zinc supplementation prevents cardiomyocyte apoptosis and congenital heart defects in embryos of diabetic mice

Free Radical Biology and Medicine

Volumn 53, Issue 8, 2012, Pages 1595-1606

  Kumar, Srinivasan Dinesh ^a,b   Vijaya, Murugaiyan ^a   Samy, Ramar Perumal ^a   Dheen, S Thameem ^a   Ren, Minqin ^c   Watt, Frank ^c   Kang, Y James ^d,e   Bay, Boon Huat ^a   Tay, Samuel Sam Wah ^a  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b NANYANG TECHNOLOGICAL UNIVERSITY   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d University of Louisville School of Medicine   (United States)

^e SICHUAN UNIVERSITY   (China)

Author keywords

Antioxidant; Cardiac malformations; Embryos; Heart; Maternal diabetes; Metallothionein; Mice; Nuclear microscopy; Oxidative stress; Zinc

Indexed keywords

CALCIUM; GLUTATHIONE; MESSENGER RNA; METALLOTHIONEIN; PHOSPHORUS; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; ZINC SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DIABETIC CARDIOMYOPATHY; EMBRYO; EMBRYOPATHY; FEMALE; HEART CELL CULTURE; HEART DEVELOPMENT; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MATERNAL DIABETES MELLITUS; MICROSCOPY; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; SUPPLEMENTATION;

ANIMALS; APOPTOSIS; BLOOD GLUCOSE; BLOTTING, WESTERN; CELLS, CULTURED; DIABETES COMPLICATIONS; DIABETES MELLITUS, EXPERIMENTAL; DIETARY SUPPLEMENTS; EMBRYO, MAMMALIAN; FEMALE; GLUTATHIONE; HEART DEFECTS, CONGENITAL; IMMUNOENZYME TECHNIQUES; LIPID PEROXIDATION; METALLOTHIONEIN; MICE; MYOCYTES, CARDIAC; NUCLEAR MICROSCOPY; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDE DISMUTASE; ZINC;

ANIMALIA; MUS; RATTUS;

EID: 84867336675     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.07.008     Document Type: Article

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