eQTL networks unveil enriched mRNA master integrators downstream of complex disease-associated SNPs

Journal of Biomedical Informatics

Volumn 58, Issue , 2015, Pages 226-234

  Li, Haiquan ^a,b   Pouladi, Nima ^a,b   Achour, Ikbel ^a,b   Gardeux, Vincent ^a,b   Li, Jianrong ^a,b   Li, Qike ^a,b   Zhang, Hao Helen ^b,c   Martinez, Fernando D ^a,b   Skip Garcia, Joe G N ^a,b   Lussier, Yves A ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c University of Arizona   (United States)

Author keywords

Big data; Centrality; Complex disease; Complex diseases; Computational biology; Computational genomics; Computational medicine; eQTL; Genetics; Genomics; Master integrator; MRNA; Network biology; Signal integration; Single Nucleotide Polymorphism (SNP); Systems biology; Systems medicine; Transcriptome; Translational bioinformatics

Indexed keywords

BIG DATA; BIOINFORMATICS; CELL CULTURE; DNA; GENETIC ALGORITHMS; NETWORK ARCHITECTURE; NUCLEOTIDES; PLANTS (BOTANY); POLYMORPHISM; PROTEINS; TISSUE; TRANSCRIPTION;

CENTRALITY; COMPLEX DISEASE; COMPUTATIONAL BIOLOGY; COMPUTATIONAL MEDICINE; EQTL; GENETICS; GENOMICS; MASTER INTEGRATOR; MRNA; NETWORK BIOLOGY; SIGNAL INTEGRATION; SINGLE-NUCLEOTIDE POLYMORPHISMS; SYSTEMS BIOLOGY; TRANSCRIPTOMES;

COMPLEX NETWORKS;

MESSENGER RNA; TRANSCRIPTOME;

ARTICLE; BIOINFORMATICS; DOWN REGULATION; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENETIC ANALYSIS; GENETIC ASSOCIATION; HUMAN; LIVER PARENCHYMA; LYMPHOBLASTOID CELL LINE; PLEIOTROPY; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMS BIOLOGY; GENETICS;

HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; QUANTITATIVE TRAIT LOCI; RNA, MESSENGER;

EID: 84947923916     PISSN: 15320464     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbi.2015.10.010     Document Type: Article

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