Cigarette smoke induces mucin hypersecretion and inflammatory response through the p66shc adaptor protein-mediated mechanism in human bronchial epithelial cells

Molecular Immunology

Volumn 69, Issue , 2016, Pages 86-98

  Yang, J ^a   Yu, H M ^a   Zhou, X D ^a,b   Huang, H P ^b   Han, Zh ^b   Kolosov, V P ^c   Perelman, J M ^c  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b HAINAN MEDICAL UNIVERSITY   (China)

^c Russian Academy of Medical Sciences   (Russian Federation)

Author keywords

Inflammation; Mitochondria; MUC5AC; NF B; p66Shc; ROS

Indexed keywords

ADAPTOR PROTEIN; ADENOSINE TRIPHOSPHATE; CIGARETTE SMOKE; CYTOCHROME C; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; MUCIN; MUCIN 5AC; P66SHC PROTEIN; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FKHRL1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; PROTEIN SHC; SHC1 PROTEIN, HUMAN; SMOKE;

AIRWAY EPITHELIAL CELL; APOPTOSIS; ARTICLE; BRONCHUS MUCOSA; CELL PROLIFERATION; CELL VIABILITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; INFLAMMATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MTT ASSAY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; WILD TYPE; ADVERSE EFFECTS; BIOSYNTHESIS; BRONCHUS; CELL LINE; DRUG EFFECTS; EPITHELIUM CELL; GENETIC TRANSFECTION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; METABOLISM; MITOCHONDRION; RESPIRATORY TRACT MUCOSA; SMOKE; TOBACCO;

BRONCHI; CELL LINE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIAL CELLS; FLOW CYTOMETRY; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INFLAMMATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MUCINS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; RESPIRATORY MUCOSA; SHC SIGNALING ADAPTOR PROTEINS; SMOKE; TOBACCO; TRANSFECTION;

EID: 84947739308     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2015.11.002     Document Type: Article

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