Taxol mediates serine phosphorylation of the 66-kDa Shc isoform

Cancer Research

Volumn 60, Issue 18, 2000, Pages 5171-5178

  Chia Ping Huang Yang, ^a   Horwitz, S B ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BACCATIN III; CELL PROTEIN; COLCHICINE; CYCLOHEXIMIDE; ELEUTHEROBIN; EPOTHILONE A; EPOTHILONE B; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHOPROTEIN PHOSPHATASE 2A; TAXOL; TAXOTERE; UNCLASSIFIED DRUG; UO 126; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; ELECTROPHORETIC MOBILITY; HUMAN; HUMAN CELL; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA; COMPARATIVE STUDY; CYANOGEN BROMIDE; CYCLOHEXIMIDE; DRUG INTERACTIONS; DRUG RESISTANCE, NEOPLASM; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENZYME INHIBITORS; FLAVONES; HUMAN; LUNG NEOPLASMS; MAP KINASE KINASE KINASES; MICROTUBULES; PACLITAXEL; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PROTEIN SYNTHESIS INHIBITORS; PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; SERINE; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; TYROSINE;

EID: 0034665140     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Paclitaxel (Taxol)
2. Taxol binds to cellular microtubules
3. Promotion of microtubule assembly in vitro by Taxol
4. Characterization of the Taxol binding site on the microtubule. Identification of arg(282) in β-tubulin as the site of photoincorporation of a 7-benzophenone analogue of Taxol
5. Taxol stabilizes microtubules in mouse fibroblast cells
6. Taxol suppresses dynamics of individual microtubules in living human tumor cells
7. Taxol induces internucleosomal DNA fragmentation associated with programmed cell death in human myeloid leukemia cells
8. Microtubule dysfunction induced by paclitaxel initiates apoptosis through both c-Jun N-terminal kinase (JNK)-dependent and -independent pathways in ovarian cancer cells
9. Comparison of paclitaxel-, 5-fluoro-2'-deoxyuridine-, and epidermal growth factor (EGF)-induced apoptosis. Evidence for EGF-induced anoikis
10. Taxol and lipopolysaccharide activation of a routine macrophage cell line and induction of similar tyrosine phosphoproteins
11. Taxol shares the ability of bacterial lipopolysaccharide to induce tyrosine phosphorylation of microtubule-associated protein kinase
12. Evidence for involvement of tyrosine phosphorylation in Taxol-induced apoptosis in a human ovarian tumor cell line
13. Taxol provides a second signal for murine macrophage tumoricidal activity
14. Relationship between the structure of Taxol and other taxanes on induction of tumor necrosis factor-α gene expression and cytotoxicity
15. Heat shock protein 90 mediates macrophage activation by Taxol and bacterial lipopolysaccharide
16. Use of a photoactivatable Taxol analogue to identify unique cellular targets in murine macrophages: Identification of murine CD18 as a major Taxol-binding protein and a role for Mac-1 in Taxol-induced gene expression
17. Screening of a library of phage-displayed peptides identifies human bcl-2 as a Taxol-binding protein
18. Induction of apoptosis by ASKI, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
19. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
20. Paclitaxel (Taxol)-induced gene expression and cell death are both mediated by the activation of c-Jun NH2-terminal kinase (JNK/SAPK)
21. Taxol induction of p21(WAF1) and p53 requires c-raf-1
22. Raf-1/bcl-2 phosphorylation: A step from microtubule damage to cell death
23. Taxol induces tyrosine phosphorylation of Shc and its association with Grb2 in murine RAW 264.7 cells
24. Mechanisms of Taxol-induced cell death are concentration dependent
25. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
26. Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells
27. A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction
28. Not all She's roads lead to Ras
29. Insulin-induced phosphorylation of the 46- and 52-kDa Shc proteins
30. Shc products are substrates of erbB-2 kinase
31. Shc proteins are phosphorylated and regulated by the v-Src and v-Fps protein-tyrosine kinases
32. Inhibition of CD4/p561ck signaling by a dominant negative mutant of the Shc adaptor protein
33. An alternative to SH2 domains for binding tyrosine-phosphorylated proteins
34. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases
35. Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway
36. Opposite effects of the p52shc/p46shc and p66shc splicing isoforms on the EGF receptor-MAP kinase-fos signalling pathway
37. The 66-kDa Shc isoform is a negative regulator of the epidermal growth factor-stimulated mitogen-activated protein kinase pathway
38. Insulin stimulates the phosphorylation of the 66- and 52-kilodalton Shc isoforms by distinct pathways
39. The p66shc adaptor protein controls oxidative stress response and life span in mammals
40. Taxol-resistant epithelial ovarian tumors are associated with altered expression of specific β-tubulin isotypes
41. High resolution two-dimensional electrophoresis of proteins
42. Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa
43. Cleavage of poly(ADP-ribose) polymerase: A sensitive parameter to study cell death
44. Mitogen-activated protein kinase pathway is dispensable for microtubule-active drug-induced Raf-1/ Bcl-2 phosphorylation and apoptosis in leukemia cells
45. Serine protease inhibitor TPCK prevents Taxol-induced cell death and blocks c-Raf-1 and Bcl-2 phosphorylation in human breast carcinoma cells
46. A novel pool of protein phosphatase 2A is associated with microtubules and is regulated during the cell cycle
47. Distinct roles of PP1 and PP2A-like phosphatases in control of microtubule dynamics during mitosis
48. Taxol and discodermolide represent a synergistic drug combination in human carcinoma cell lines
49. Epothilone B stabilizes microtubuli of macrophages like Taxol without showing Taxol-like endotoxin activity
50. Taxane-mediated gene induction is independent of microtubule stabilization: Induction of transcription regulators and enzymes that modulate inflammation and apoptosis
51. Blocked signal transduction to the ERK and JNK protein kinases in anergic CD4+ T cells
52. Possible mechanisms of paclitaxel-induced apoptosis
53. Taxol: Mechanisms of action and resistance
54. A β-tubulin leucine cluster involved in microtubule assembly and paclitaxel resistance
55. Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms
56. Molecular effects of paclitaxel: Myths and reality (a critical review)