Cold temperature induces mucin hypersecretion from normal human bronchial epithelial cells in vitro through a transient receptor potential melastatin 8 (TRPM8)-mediated mechanism

Journal of Allergy and Clinical Immunology

Volumn 128, Issue 3, 2011, Pages

  Li, Minchao ^a   Li, Qi ^a   Yang, Gang ^a   Kolosov, Victor P ^b   Perelman, Juliy M ^b   Zhou, Xiang Dong ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

^b Russian Academy of Medical Sciences   (Russian Federation)

Author keywords

cold air; MUC5AC; mucus hypersecretion; myristoylated alanine rich C kinase substrate; phosphatidylinositol 4,5 bisphosphate; Transient receptor potential melastatin 8

Indexed keywords

CALCIUM ION; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; MARCKS PROTEIN; MESSENGER RNA; MUCIN; MUCIN 5AC; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHOLIPASE C DELTA1; PLECKSTRIN; SERINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL M8;

ADULT; AGED; AIRWAY; ARTICLE; BINDING SITE; BRONCHIAL EPITHELIAL CELL; BRONCHUS MUCOSA; BRONCHUS MUCUS; CALCIUM CELL LEVEL; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; COLD AIR; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIUM CELL; FEMALE; GENE MUTATION; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MALE; MEDIATOR; MOLECULAR DYNAMICS; MOLECULAR IMAGING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 80052267978     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.04.032     Document Type: Article

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