Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis

Applied Biochemistry and Biotechnology

Volumn 177, Issue 8, 2015, Pages 1716-1728

  Yin, Jie ^a,b   Wu, Miaomiao ^a,b   Duan, Jielin ^a,b   Liu, Gang ^a   Cui, Zhijie ^a,b   Zheng, Jie ^c   Chen, Shuai ^a   Ren, Wenkai ^a   Deng, Jinping ^c   Tan, Xiangwen ^d   Al Dhabi, Naif Abdullah ^e   Duraipandiyan, Veeramuthu ^e   Liao, Peng ^a   Li, Tiejun ^a   Yulong, Yin ^a  

^a INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

^c HUNAN AGRICULTURAL UNIVERSITY   (China)

^d UNIVERSITY OF SOUTH CHINA   (China)

^e KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Antioxidant gene; IBD; NF B; PDTC; Tight junction

Indexed keywords

CHEMICAL ACTIVATION; DISEASES; LIVING SYSTEMS STUDIES; PATHOLOGY; PATIENT TREATMENT; SODIUM SULFATE; TRANSCRIPTION;

ANTI-INFLAMMATORY FUNCTION; ANTIOXIDANT ENZYME; IBD; INFLAMMATORY BOWEL DISEASE; NUCLEAR TRANSCRIPTION FACTORS; PDTC; SIGNALING PATHWAYS; TIGHT JUNCTIONS;

ANTIOXIDANTS;

CATALASE; COMPLEMENTARY DNA; COPPER ZINC SUPEROXIDE DISMUTASE; DEXTRAN SULFATE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE PEROXIDASE 2; GLUTATHIONE PEROXIDASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MESSENGER RNA; OCCLUDIN; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; PROTEIN ZO1; PYRROLIDINE DITHIOCARBAMATE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 4, MOUSE; PYRROLIDINE DERIVATIVE; PYRROLIDINE DITHIOCARBAMIC ACID; THIOCARBAMIC ACID DERIVATIVE; TJP1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLITIS; COLON; CONTROLLED STUDY; DNA SYNTHESIS; DOWN REGULATION; GENE EXPRESSION; ILEUM; INFLAMMATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TIGHT JUNCTION; UPREGULATION; WEIGHT GAIN; WEIGHT REDUCTION; WESTERN BLOTTING; ANIMAL; CHEMICALLY INDUCED; DISEASE MODEL; GENETICS; IMMUNOLOGY; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM;

ANIMALS; COLITIS; CYTOKINES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; GLUTATHIONE PEROXIDASE; MALE; MICE; MICE, INBRED ICR; NF-KAPPA B; OCCLUDIN; PYRROLIDINES; SIGNAL TRANSDUCTION; THIOCARBAMATES; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84947615718     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-015-1848-z     Document Type: Article

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