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Volumn 39, Issue 6, 2014, Pages 579-594

Review article: Anti-adhesion therapies for inflammatory bowel disease

Author keywords

[No Author keywords available]

Indexed keywords

ADDRESSIN; AJM 300; ALICAFORSEN; ALPHA4 BETA7 INTEGRIN; ALPHAE BETA7 INTEGRIN; AMG 181; C REACTIVE PROTEIN; CALGRANULIN; CCX 282 B; CELL ADHESION MOLECULE; CHEMOKINE RECEPTOR CCR9; ETROLIZUMAB; FENYRAMIDOL; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; MUCOSAL ADDRESSIN CELL ADHESION MOLECULE 1; NATALIZUMAB; PF 00547659; PLACEBO; UNCLASSIFIED DRUG; VEDOLIZUMAB; VERCIRNON; VERY LATE ACTIVATION ANTIGEN 4;

EID: 84894589499     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/apt.12639     Document Type: Review
Times cited : (155)

References (121)
  • 1
    • 2442571121 scopus 로고    scopus 로고
    • Autoimmune disorders and extraintestinal manifestations in first-degree familial and sporadic inflammatory bowel disease: A case-control study
    • Ricart E, Panaccione R, Loftus EV, et al,. Autoimmune disorders and extraintestinal manifestations in first-degree familial and sporadic inflammatory bowel disease: a case-control study. Inflamm Bowel Dis 2004; 10: 207-14.
    • (2004) Inflamm Bowel Dis , vol.10 , pp. 207-214
    • Ricart, E.1    Panaccione, R.2    Loftus, E.V.3
  • 2
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR,. Inflammatory bowel disease: cause and immunobiology. Lancet 2007; 369: 1627-40.
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 3
    • 79959561435 scopus 로고    scopus 로고
    • Optimizing clinical use of mesalazine (5-aminosalicylic acid) in inflammatory bowel disease
    • Williams C, Panaccione R, Ghosh S, Rioux K,. Optimizing clinical use of mesalazine (5-aminosalicylic acid) in inflammatory bowel disease. Therap Adv Gastroenterol 2011; 4: 237-48.
    • (2011) Therap Adv Gastroenterol , vol.4 , pp. 237-248
    • Williams, C.1    Panaccione, R.2    Ghosh, S.3    Rioux, K.4
  • 4
    • 79952196928 scopus 로고    scopus 로고
    • Aminosalicylates for induction of remission or response in Crohn's disease
    • Lim WC, Hanauer S,. Aminosalicylates for induction of remission or response in Crohn's disease. Cochrane Database Syst Rev 2010; 12: CD008870.
    • (2010) Cochrane Database Syst Rev , vol.12
    • Lim, W.C.1    Hanauer, S.2
  • 5
    • 75149161836 scopus 로고    scopus 로고
    • The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Current management
    • Dignass A, Van Assche G, Lindsay JO, et al,. The second European evidence-based consensus on the diagnosis and management of Crohn's disease: current management. J Crohns Colitis 2010; 4: 28-62.
    • (2010) J Crohns Colitis , vol.4 , pp. 28-62
    • Dignass, A.1    Van Assche, G.2    Lindsay, J.O.3
  • 6
    • 84869089859 scopus 로고    scopus 로고
    • Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: Current management
    • Dignass A, Lindsay JO, Sturm A, et al,. Second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management. J Crohns Colitis 2012; 6: 991-1030.
    • (2012) J Crohns Colitis , vol.6 , pp. 991-1030
    • Dignass, A.1    Lindsay, J.O.2    Sturm, A.3
  • 7
    • 68949209778 scopus 로고    scopus 로고
    • Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine/mercaptopurine
    • Wahed M, Louis-Auguste JR, Baxter LM, et al,. Efficacy of methotrexate in Crohn's disease and ulcerative colitis patients unresponsive or intolerant to azathioprine/mercaptopurine. Aliment Pharmacol Ther 2009; 30: 614-20.
    • (2009) Aliment Pharmacol Ther , vol.30 , pp. 614-620
    • Wahed, M.1    Louis-Auguste, J.R.2    Baxter, L.M.3
  • 8
    • 22644446331 scopus 로고    scopus 로고
    • Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine
    • Kandiel A, Fraser AG, Korelitz BI, Brensinger C, Lewis JD,. Increased risk of lymphoma among inflammatory bowel disease patients treated with azathioprine and 6-mercaptopurine. Gut 2005; 54: 1121-5.
    • (2005) Gut , vol.54 , pp. 1121-1125
    • Kandiel, A.1    Fraser, A.G.2    Korelitz, B.I.3    Brensinger, C.4    Lewis, J.D.5
  • 10
    • 0037018761 scopus 로고    scopus 로고
    • Maintenance infliximab for Crohn's disease: The ACCENT i randomised trial
    • Hanauer SB, Feagan BG, Lichtenstein GR, et al,. Maintenance infliximab for Crohn's disease: the ACCENT I randomised trial. Lancet 2002; 359: 1541-9.
    • (2002) Lancet , vol.359 , pp. 1541-1549
    • Hanauer, S.B.1    Feagan, B.G.2    Lichtenstein, G.R.3
  • 11
    • 28844473957 scopus 로고    scopus 로고
    • Infliximab for induction and maintenance therapy for ulcerative colitis
    • Rutgeerts P, Sandborn WJ, Feagan BG, et al,. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med 2005; 353: 2462-76.
    • (2005) N Engl J Med , vol.353 , pp. 2462-2476
    • Rutgeerts, P.1    Sandborn, W.J.2    Feagan, B.G.3
  • 12
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
    • Colombel JF, Sandborn WJ, Rutgeerts P, et al,. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology 2007; 132: 52-65.
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, J.F.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 13
    • 84872832486 scopus 로고    scopus 로고
    • One-year maintenance outcomes among patients with moderately-to-severely active ulcerative colitis who responded to induction therapy with adalimumab: Subgroup analyses from ULTRA 2
    • Sandborn WJ, Colombel JF, D'Haens G, et al,. One-year maintenance outcomes among patients with moderately-to-severely active ulcerative colitis who responded to induction therapy with adalimumab: subgroup analyses from ULTRA 2. Aliment Pharmacol Ther 2013; 37: 204-13.
    • (2013) Aliment Pharmacol Ther , vol.37 , pp. 204-213
    • Sandborn, W.J.1    Colombel, J.F.2    D'Haens, G.3
  • 14
    • 34447523749 scopus 로고    scopus 로고
    • Certolizumab pegol for the treatment of Crohn's disease
    • Sandborn WJ, Feagan BG, Stoinov S, et al,. Certolizumab pegol for the treatment of Crohn's disease. N Engl J Med 2007; 357: 228-38.
    • (2007) N Engl J Med , vol.357 , pp. 228-238
    • Sandborn, W.J.1    Feagan, B.G.2    Stoinov, S.3
  • 15
    • 34447515607 scopus 로고    scopus 로고
    • Maintenance therapy with certolizumab pegol for Crohn's disease
    • Schreiber S, Khaliq-Kareemi M, Lawrance IC, et al,. Maintenance therapy with certolizumab pegol for Crohn's disease. N Engl J Med 2007; 357: 239-50.
    • (2007) N Engl J Med , vol.357 , pp. 239-250
    • Schreiber, S.1    Khaliq-Kareemi, M.2    Lawrance, I.C.3
  • 16
    • 84890620601 scopus 로고    scopus 로고
    • Subcutaneous Golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis
    • Sandborn WJ, Feagan BG, Marano C, et al,. Subcutaneous Golimumab induces clinical response and remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology 2014; 146: 85-95.
    • (2014) Gastroenterology , vol.146 , pp. 85-95
    • Sandborn, W.J.1    Feagan, B.G.2    Marano, C.3
  • 17
  • 18
    • 84894593389 scopus 로고    scopus 로고
    • Adalimumab in the treatment of moderate-to-severe ulcerative colitis: ULTRA 2 trial results
    • No authors listed
    • No authors listed. Adalimumab in the treatment of moderate-to-severe ulcerative colitis: ULTRA 2 trial results. Gastroenterol Hepatol (N Y) 2013; 9: 317-20.
    • (2013) Gastroenterol Hepatol (N Y) , vol.9 , pp. 317-320
  • 19
    • 79953688705 scopus 로고    scopus 로고
    • Review article: Loss of response to anti-TNF treatments in Crohn's disease
    • Ben-Horin S, Chowers Y,. Review article: loss of response to anti-TNF treatments in Crohn's disease. Aliment Pharmacol Ther 2011; 33: 987-95.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 987-995
    • Ben-Horin, S.1    Chowers, Y.2
  • 20
    • 0037434552 scopus 로고    scopus 로고
    • Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease
    • Baert F, Noman M, Vermeire S, et al,. Influence of immunogenicity on the long-term efficacy of infliximab in Crohn's disease. N Engl J Med 2003; 348: 601-8.
    • (2003) N Engl J Med , vol.348 , pp. 601-608
    • Baert, F.1    Noman, M.2    Vermeire, S.3
  • 21
    • 34548130215 scopus 로고    scopus 로고
    • Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease
    • Vermeire S, Noman M, Van Assche G, Baert F, D'Haens G, Rutgeerts P,. Effectiveness of concomitant immunosuppressive therapy in suppressing the formation of antibodies to infliximab in Crohn's disease. Gut 2007; 56: 1226-31.
    • (2007) Gut , vol.56 , pp. 1226-1231
    • Vermeire, S.1    Noman, M.2    Van Assche, G.3    Baert, F.4    D'Haens, G.5    Rutgeerts, P.6
  • 22
    • 0037379792 scopus 로고    scopus 로고
    • Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: A randomized controlled trial
    • Farrell RJ, Alsahli M, Jeen YT, Falchuk KR, Peppercorn MA, Michetti P,. Intravenous hydrocortisone premedication reduces antibodies to infliximab in Crohn's disease: a randomized controlled trial. Gastroenterology 2003; 124: 917-24.
    • (2003) Gastroenterology , vol.124 , pp. 917-924
    • Farrell, R.J.1    Alsahli, M.2    Jeen, Y.T.3    Falchuk, K.R.4    Peppercorn, M.A.5    Michetti, P.6
  • 23
    • 79952788410 scopus 로고    scopus 로고
    • Review article: Remission rates achievable by current therapies for inflammatory bowel disease
    • Peyrin-Biroulet L, Lémann M,. Review article: remission rates achievable by current therapies for inflammatory bowel disease. Aliment Pharmacol Ther 2011; 33: 870-9.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 870-879
    • Peyrin-Biroulet, L.1    Lémann, M.2
  • 24
    • 34347402306 scopus 로고    scopus 로고
    • Adalimumab induction therapy for Crohn disease previously treated with infliximab: A randomized trial
    • Sandborn WJ, Rutgeerts P, Enns R, et al,. Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med 2007; 146: 829-38.
    • (2007) Ann Intern Med , vol.146 , pp. 829-838
    • Sandborn, W.J.1    Rutgeerts, P.2    Enns, R.3
  • 25
    • 79953018875 scopus 로고    scopus 로고
    • Adverse effects of biologics: A network meta-analysis and Cochrane overview
    • Singh JA, Wells GA, Christensen R, et al,. Adverse effects of biologics: a network meta-analysis and Cochrane overview. Cochrane Database Syst Rev 2011; 2: CD008794.
    • (2011) Cochrane Database Syst Rev , vol.2
    • Singh, J.A.1    Wells, G.A.2    Christensen, R.3
  • 26
    • 33646696885 scopus 로고    scopus 로고
    • Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: Systematic review and meta-analysis of rare harmful effects in randomized controlled trials
    • Bongartz T, Sutton AJ, Sweeting MJ, Buchan I, Matteson EL, Montori V,. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006; 295: 2275-85.
    • (2006) JAMA , vol.295 , pp. 2275-2285
    • Bongartz, T.1    Sutton, A.J.2    Sweeting, M.J.3    Buchan, I.4    Matteson, E.L.5    Montori, V.6
  • 27
    • 33646147141 scopus 로고    scopus 로고
    • Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry
    • Lichtenstein GR, Feagan BG, Cohen RD, et al,. Serious infections and mortality in association with therapies for Crohn's disease: TREAT registry. Clin Gastroenterol Hepatol 2006; 4: 621-30.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 621-630
    • Lichtenstein, G.R.1    Feagan, B.G.2    Cohen, R.D.3
  • 29
    • 70449100743 scopus 로고    scopus 로고
    • Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: A prospective observational cohort study
    • Beaugerie L, Brousse N, Bouvier AM, et al,. Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study. Lancet 2009; 374: 1617-25.
    • (2009) Lancet , vol.374 , pp. 1617-1625
    • Beaugerie, L.1    Brousse, N.2    Bouvier, A.M.3
  • 31
    • 4544381908 scopus 로고    scopus 로고
    • Systematic review: Has disease outcome in Crohn's disease changed during the last four decades?
    • Wolters FL, Russel MG, Stockbrügger RW,. Systematic review: has disease outcome in Crohn's disease changed during the last four decades? Aliment Pharmacol Ther 2004; 20: 483-96.
    • (2004) Aliment Pharmacol Ther , vol.20 , pp. 483-496
    • Wolters, F.L.1    Russel, M.G.2    Stockbrügger, R.W.3
  • 32
    • 0028338424 scopus 로고
    • Course of ulcerative colitis: Analysis of changes in disease activity over years
    • Langholz E, Munkholm P, Davidsen M, Binder V,. Course of ulcerative colitis: analysis of changes in disease activity over years. Gastroenterology 1994; 107: 3-11.
    • (1994) Gastroenterology , vol.107 , pp. 3-11
    • Langholz, E.1    Munkholm, P.2    Davidsen, M.3    Binder, V.4
  • 33
    • 84870857072 scopus 로고    scopus 로고
    • Decreasing colectomy rates for ulcerative colitis: A population-based time trend study
    • Kaplan GG, Seow CH, Ghosh S, et al,. Decreasing colectomy rates for ulcerative colitis: a population-based time trend study. Am J Gastroenterol 2012; 107: 1879-87.
    • (2012) Am J Gastroenterol , vol.107 , pp. 1879-1887
    • Kaplan, G.G.1    Seow, C.H.2    Ghosh, S.3
  • 34
    • 79958228566 scopus 로고    scopus 로고
    • Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease
    • Peyrin-Biroulet L, Oussalah A, Williet N, Pillot C, Bresler L, Bigard MA,. Impact of azathioprine and tumour necrosis factor antagonists on the need for surgery in newly diagnosed Crohn's disease. Gut 2011; 60: 930-6.
    • (2011) Gut , vol.60 , pp. 930-936
    • Peyrin-Biroulet, L.1    Oussalah, A.2    Williet, N.3    Pillot, C.4    Bresler, L.5    Bigard, M.A.6
  • 35
    • 84871701834 scopus 로고    scopus 로고
    • Ustekinumab induction and maintenance therapy in refractory Crohn's disease
    • Sandborn WJ, Gasink C, Gao LL, et al,. Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med 2012; 367: 1519-28.
    • (2012) N Engl J Med , vol.367 , pp. 1519-1528
    • Sandborn, W.J.1    Gasink, C.2    Gao, L.L.3
  • 37
    • 84894581266 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01393899, Accessed January 7, 2014
    • ClinicalTrials.gov. The safety and efficacy of maintenance therapy with CP-690,550. NCT01393899, 2014. Available at: http://clinicaltrials.gov/show/ NCT01393899. Accessed January 7, 2014.
    • (2014) The Safety and Efficacy of Maintenance Therapy with CP-690,550
  • 38
    • 12344278984 scopus 로고    scopus 로고
    • Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease
    • Van Assche G, Rutgeerts P,. Physiological basis for novel drug therapies used to treat the inflammatory bowel diseases. I. Immunology and therapeutic potential of antiadhesion molecule therapy in inflammatory bowel disease. Am J Physiol Gastrointest Liver Physiol 2005; 288: G169-74.
    • (2005) Am J Physiol Gastrointest Liver Physiol , vol.288
    • Van Assche, G.1    Rutgeerts, P.2
  • 39
    • 84861318436 scopus 로고    scopus 로고
    • Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis
    • Thomas S, Baumgart DC,. Targeting leukocyte migration and adhesion in Crohn's disease and ulcerative colitis. Inflammopharmacology 2012; 20: 1-18.
    • (2012) Inflammopharmacology , vol.20 , pp. 1-18
    • Thomas, S.1    Baumgart, D.C.2
  • 40
    • 0034609968 scopus 로고    scopus 로고
    • T-cell function and migration. Two sides of the same coin
    • Von Andrian UH, Mackay CR,. T-cell function and migration. Two sides of the same coin. N Engl J Med 2000; 343: 1020-34.
    • (2000) N Engl J Med , vol.343 , pp. 1020-1034
    • Von Andrian, U.H.1    Mackay, C.R.2
  • 41
    • 0032904627 scopus 로고    scopus 로고
    • Mechanisms that regulate the function of the selectins and their ligands
    • Vestweber D, Blanks JE,. Mechanisms that regulate the function of the selectins and their ligands. Physiol Rev 1999; 79: 181-213.
    • (1999) Physiol Rev , vol.79 , pp. 181-213
    • Vestweber, D.1    Blanks, J.E.2
  • 42
    • 0025854524 scopus 로고
    • Leukocytes roll on a selectin at physiologic flow rates: Distinction from and prerequisite for adhesion through integrins
    • Lawrence MB, Springer TA,. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 1991; 65: 859-73.
    • (1991) Cell , vol.65 , pp. 859-873
    • Lawrence, M.B.1    Springer, T.A.2
  • 43
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes RO,. Integrins: bidirectional, allosteric signaling machines. Cell 2002; 110: 673-87.
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 44
    • 0023644247 scopus 로고
    • Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1)
    • Marlin SD, Springer TA,. Purified intercellular adhesion molecule-1 (ICAM-1) is a ligand for lymphocyte function-associated antigen 1 (LFA-1). Cell 1987; 51: 813-19.
    • (1987) Cell , vol.51 , pp. 813-819
    • Marlin, S.D.1    Springer, T.A.2
  • 45
    • 0031978507 scopus 로고    scopus 로고
    • Leukocyte-endothelial cell interactions: Molecular mechanisms and implications in gastrointestinal disease
    • Panés J, Granger DN,. Leukocyte-endothelial cell interactions: molecular mechanisms and implications in gastrointestinal disease. Gastroenterology 1998; 114: 1066-90.
    • (1998) Gastroenterology , vol.114 , pp. 1066-1090
    • Panés, J.1    Granger, D.N.2
  • 46
    • 0025161990 scopus 로고
    • VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site
    • Elices MJ, Osborn L, Takada Y, et al,. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990; 60: 577-84.
    • (1990) Cell , vol.60 , pp. 577-584
    • Elices, M.J.1    Osborn, L.2    Takada, Y.3
  • 47
    • 0029670925 scopus 로고    scopus 로고
    • Alpha 4 integrin plays a critical role in early stages of T lymphocyte migration in Peyer's patches of rats
    • Tsuzuki Y, Miura S, Suematsu M, et al,. Alpha 4 integrin plays a critical role in early stages of T lymphocyte migration in Peyer's patches of rats. Int Immunol 1996; 8: 287-95.
    • (1996) Int Immunol , vol.8 , pp. 287-295
    • Tsuzuki, Y.1    Miura, S.2    Suematsu, M.3
  • 48
    • 0026655693 scopus 로고
    • Cloning and expression of mouse integrin beta p(beta 7): A functional role in Peyer's patch-specific lymphocyte homing
    • Hu MC, Crowe DT, Weissman IL, Holzmann B,. Cloning and expression of mouse integrin beta p(beta 7): a functional role in Peyer's patch-specific lymphocyte homing. Proc Natl Acad Sci U S A 1992; 89: 8254-8.
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 8254-8258
    • Hu, M.C.1    Crowe, D.T.2    Weissman, I.L.3    Holzmann, B.4
  • 49
    • 0031092633 scopus 로고    scopus 로고
    • Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4 + T cells
    • Picarella D, Hurlbut P, Rottman J, Shi X, Butcher E, Ringler DJ,. Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4 + T cells. J Immunol 1997; 158: 2099-106.
    • (1997) J Immunol , vol.158 , pp. 2099-2106
    • Picarella, D.1    Hurlbut, P.2    Rottman, J.3    Shi, X.4    Butcher, E.5    Ringler, D.J.6
  • 50
    • 0027324601 scopus 로고
    • Integrin alpha e beta 7 mediates adhesion of T lymphocytes to epithelial cells
    • Cepek KL, Parker CM, Madara JL, Brenner MB,. Integrin alpha E beta 7 mediates adhesion of T lymphocytes to epithelial cells. J Immunol 1993; 150: 3459-70.
    • (1993) J Immunol , vol.150 , pp. 3459-3470
    • Cepek, K.L.1    Parker, C.M.2    Madara, J.L.3    Brenner, M.B.4
  • 51
    • 7844248659 scopus 로고    scopus 로고
    • Altered expression of alpha e beta 7 integrin on intra-epithelial and lamina propria lymphocytes in patients with Crohn's disease
    • Elewaut D, Van Damme N, De Keyser F, et al,. Altered expression of alpha E beta 7 integrin on intra-epithelial and lamina propria lymphocytes in patients with Crohn's disease. Acta Gastroenterol Belg 1998; 61: 288-94.
    • (1998) Acta Gastroenterol Belg , vol.61 , pp. 288-294
    • Elewaut, D.1    Van Damme, N.2    De Keyser, F.3
  • 52
    • 3242737793 scopus 로고    scopus 로고
    • Differential expression of homing receptor CD103 on lamina propria lymphocytes and association of CD103 with epithelial adhesion molecules in inflammatory bowel disease
    • Oshitani N, Watanabe K, Maeda K, et al,. Differential expression of homing receptor CD103 on lamina propria lymphocytes and association of CD103 with epithelial adhesion molecules in inflammatory bowel disease. Int J Mol Med 2003; 12: 715-19.
    • (2003) Int J Mol Med , vol.12 , pp. 715-719
    • Oshitani, N.1    Watanabe, K.2    Maeda, K.3
  • 53
    • 0033151953 scopus 로고    scopus 로고
    • Mucosal T lymphocyte numbers are selectively reduced in integrin alpha e (CD103)-deficient mice
    • Schön MP, Arya A, Murphy EA, et al,. Mucosal T lymphocyte numbers are selectively reduced in integrin alpha E (CD103)-deficient mice. J Immunol 1999; 162: 6641-9.
    • (1999) J Immunol , vol.162 , pp. 6641-6649
    • Schön, M.P.1    Arya, A.2    Murphy, E.A.3
  • 55
    • 0031052899 scopus 로고    scopus 로고
    • Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation
    • Meenan J, Spaans J, Grool TA, Pals ST, Tytgat GN, van Deventer SJ,. Altered expression of alpha 4 beta 7, a gut homing integrin, by circulating and mucosal T cells in colonic mucosal inflammation. Gut 1997; 40: 241-6.
    • (1997) Gut , vol.40 , pp. 241-246
    • Meenan, J.1    Spaans, J.2    Grool, T.A.3    Pals, S.T.4    Tytgat, G.N.5    Van Deventer, S.J.6
  • 56
    • 84876348570 scopus 로고    scopus 로고
    • Effect of tumor necrosis factor-α blockade on mucosal addressin cell-adhesion molecule-1 in Crohn's disease
    • Biancheri P, Di Sabatino A, Rovedatti L, et al,. Effect of tumor necrosis factor-α blockade on mucosal addressin cell-adhesion molecule-1 in Crohn's disease. Inflamm Bowel Dis 2013; 19: 259-64.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 259-264
    • Biancheri, P.1    Di Sabatino, A.2    Rovedatti, L.3
  • 57
    • 0032923705 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis
    • Baert FJ, D'Haens GR, Peeters M, et al,. Tumor necrosis factor alpha antibody (infliximab) therapy profoundly down-regulates the inflammation in Crohn's ileocolitis. Gastroenterology 1999; 116: 22-8.
    • (1999) Gastroenterology , vol.116 , pp. 22-28
    • Baert, F.J.1    D'Haens, G.R.2    Peeters, M.3
  • 58
    • 0029914865 scopus 로고    scopus 로고
    • Activation of T lymphocytes by syngeneic murine intestinal smooth muscle cells
    • Hogaboam CM, Snider DP, Collins SM,. Activation of T lymphocytes by syngeneic murine intestinal smooth muscle cells. Gastroenterology 1996; 110: 1456-66.
    • (1996) Gastroenterology , vol.110 , pp. 1456-1466
    • Hogaboam, C.M.1    Snider, D.P.2    Collins, S.M.3
  • 60
    • 0037192934 scopus 로고    scopus 로고
    • Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior
    • Li Z, Calzada MJ, Sipes JM, et al,. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. J Cell Biol 2002; 157: 509-19.
    • (2002) J Cell Biol , vol.157 , pp. 509-519
    • Li, Z.1    Calzada, M.J.2    Sipes, J.M.3
  • 61
    • 0035918153 scopus 로고    scopus 로고
    • Identification of dual alpha 4beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin
    • Bayless KJ, Davis GE,. Identification of dual alpha 4beta1 integrin binding sites within a 38 amino acid domain in the N-terminal thrombin fragment of human osteopontin. J Biol Chem 2001; 276: 13483-9.
    • (2001) J Biol Chem , vol.276 , pp. 13483-13489
    • Bayless, K.J.1    Davis, G.E.2
  • 62
    • 0028898488 scopus 로고
    • Dual binding capacity of mucosal immunoblasts to mucosal and synovial endothelium in humans: Dissection of the molecular mechanisms
    • Salmi M, Andrew DP, Butcher EC, Jalkanen S,. Dual binding capacity of mucosal immunoblasts to mucosal and synovial endothelium in humans: dissection of the molecular mechanisms. J Exp Med 1995; 181: 137-49.
    • (1995) J Exp Med , vol.181 , pp. 137-149
    • Salmi, M.1    Andrew, D.P.2    Butcher, E.C.3    Jalkanen, S.4
  • 63
    • 4043099125 scopus 로고    scopus 로고
    • Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease
    • Eksteen B, Miles AE, Grant AJ, Adams DH,. Lymphocyte homing in the pathogenesis of extra-intestinal manifestations of inflammatory bowel disease. Clin Med 2004; 4: 173-80.
    • (2004) Clin Med , vol.4 , pp. 173-180
    • Eksteen, B.1    Miles, A.E.2    Grant, A.J.3    Adams, D.H.4
  • 64
    • 0035029326 scopus 로고    scopus 로고
    • MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease)
    • Grant AJ, Lalor PF, Hübscher SG, Briskin M, Adams DH,. MAdCAM-1 expressed in chronic inflammatory liver disease supports mucosal lymphocyte adhesion to hepatic endothelium (MAdCAM-1 in chronic inflammatory liver disease). Hepatology 2001; 33: 1065-72.
    • (2001) Hepatology , vol.33 , pp. 1065-1072
    • Grant, A.J.1    Lalor, P.F.2    Hübscher, S.G.3    Briskin, M.4    Adams, D.H.5
  • 65
    • 0026506799 scopus 로고
    • Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin
    • Yednock TA, Cannon C, Fritz LC, Sanchez-Madrid F, Steinman L, Karin N,. Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin. Nature 1992; 356: 63-6.
    • (1992) Nature , vol.356 , pp. 63-66
    • Yednock, T.A.1    Cannon, C.2    Fritz, L.C.3    Sanchez-Madrid, F.4    Steinman, L.5    Karin, N.6
  • 66
    • 33644584352 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
    • Polman CH, O'Connor PW, Havrdova E, et al,. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N Engl J Med 2006; 354: 899-910.
    • (2006) N Engl J Med , vol.354 , pp. 899-910
    • Polman, C.H.1    O'Connor, P.W.2    Havrdova, E.3
  • 67
    • 33644608613 scopus 로고    scopus 로고
    • Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
    • Rudick RA, Stuart WH, Calabresi PA, et al,. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med 2006; 354: 911-23.
    • (2006) N Engl J Med , vol.354 , pp. 911-923
    • Rudick, R.A.1    Stuart, W.H.2    Calabresi, P.A.3
  • 68
    • 0034903450 scopus 로고    scopus 로고
    • A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease
    • Gordon FH, Lai CW, Hamilton MI, et al,. A randomized placebo-controlled trial of a humanized monoclonal antibody to alpha4 integrin in active Crohn's disease. Gastroenterology 2001; 121: 268-74.
    • (2001) Gastroenterology , vol.121 , pp. 268-274
    • Gordon, F.H.1    Lai, C.W.2    Hamilton, M.I.3
  • 69
    • 0037413468 scopus 로고    scopus 로고
    • Natalizumab for active Crohn's disease
    • Ghosh S, Goldin E, Gordon FH, et al,. Natalizumab for active Crohn's disease. N Engl J Med 2003; 348: 24-32.
    • (2003) N Engl J Med , vol.348 , pp. 24-32
    • Ghosh, S.1    Goldin, E.2    Gordon, F.H.3
  • 70
    • 27644441529 scopus 로고    scopus 로고
    • Natalizumab induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Colombel JF, Enns R, et al,. Natalizumab induction and maintenance therapy for Crohn's disease. N Engl J Med 2005; 353: 1912-25.
    • (2005) N Engl J Med , vol.353 , pp. 1912-1925
    • Sandborn, W.J.1    Colombel, J.F.2    Enns, R.3
  • 71
    • 34247884424 scopus 로고    scopus 로고
    • Natalizumab for the treatment of active Crohn's disease: Results of the ENCORE Trial
    • Targan SR, Feagan BG, Fedorak RN, et al,. Natalizumab for the treatment of active Crohn's disease: results of the ENCORE Trial. Gastroenterology 2007; 132: 1672-83.
    • (2007) Gastroenterology , vol.132 , pp. 1672-1683
    • Targan, S.R.1    Feagan, B.G.2    Fedorak, R.N.3
  • 72
    • 0036110371 scopus 로고    scopus 로고
    • A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha-4 integrin
    • Gordon FH, Hamilton MI, Donoghue S, et al,. A pilot study of treatment of active ulcerative colitis with natalizumab, a humanized monoclonal antibody to alpha-4 integrin. Aliment Pharmacol Ther 2002; 16: 699-705.
    • (2002) Aliment Pharmacol Ther , vol.16 , pp. 699-705
    • Gordon, F.H.1    Hamilton, M.I.2    Donoghue, S.3
  • 73
    • 61449227381 scopus 로고    scopus 로고
    • Decrease in the numbers of dendritic cells and CD4 + T cells in cerebral perivascular spaces due to natalizumab
    • Del Pilar Martin M, Cravens PD, Winger R, et al,. Decrease in the numbers of dendritic cells and CD4 + T cells in cerebral perivascular spaces due to natalizumab. Arch Neurol 2008; 65: 1596-603.
    • (2008) Arch Neurol , vol.65 , pp. 1596-1603
    • Del Pilar Martin, M.1    Cravens, P.D.2    Winger, R.3
  • 74
    • 84861022041 scopus 로고    scopus 로고
    • Risk of natalizumab-associated progressive multifocal leukoencephalopathy
    • Bloomgren G, Richman S, Hotermans C, et al,. Risk of natalizumab- associated progressive multifocal leukoencephalopathy. N Engl J Med 2012; 366: 1870-80.
    • (2012) N Engl J Med , vol.366 , pp. 1870-1880
    • Bloomgren, G.1    Richman, S.2    Hotermans, C.3
  • 75
    • 33644605483 scopus 로고    scopus 로고
    • Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy
    • Yousry TA, Major EO, Ryschkewitsch C, et al,. Evaluation of patients treated with natalizumab for progressive multifocal leukoencephalopathy. N Engl J Med 2006; 354: 924-33.
    • (2006) N Engl J Med , vol.354 , pp. 924-933
    • Yousry, T.A.1    Major, E.O.2    Ryschkewitsch, C.3
  • 76
    • 0000788815 scopus 로고    scopus 로고
    • An ascending dose trial of a humanized A4B7 antibody in ulcerative colitis
    • Feagan BG, McDonald J, Greenberg G, et al,. An ascending dose trial of a humanized A4B7 antibody in ulcerative colitis. Gastroenterology 2000; 118: A874.
    • (2000) Gastroenterology , vol.118
    • Feagan, B.G.1    McDonald, J.2    Greenberg, G.3
  • 77
    • 20444469332 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al,. Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin. N Engl J Med 2005; 352: 2499-507.
    • (2005) N Engl J Med , vol.352 , pp. 2499-2507
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 78
    • 57249089077 scopus 로고    scopus 로고
    • Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin
    • Feagan BG, Greenberg GR, Wild G, et al,. Treatment of active Crohn's disease with MLN0002, a humanized antibody to the alpha4beta7 integrin. Clin Gastroenterol Hepatol 2008; 6: 1370-7.
    • (2008) Clin Gastroenterol Hepatol , vol.6 , pp. 1370-1377
    • Feagan, B.G.1    Greenberg, G.R.2    Wild, G.3
  • 79
    • 84863984524 scopus 로고    scopus 로고
    • Vedolizumab for the treatment of active ulcerative colitis: A randomized controlled phase 2 dose-ranging study
    • Parikh A, Leach T, Wyant T, et al,. Vedolizumab for the treatment of active ulcerative colitis: a randomized controlled phase 2 dose-ranging study. Inflamm Bowel Dis 2012; 18: 1470-9.
    • (2012) Inflamm Bowel Dis , vol.18 , pp. 1470-1479
    • Parikh, A.1    Leach, T.2    Wyant, T.3
  • 80
    • 84884538154 scopus 로고    scopus 로고
    • Long-term clinical experience with vedolizumab in patients with inflammatory bowel disease
    • Parikh A, Fox I, Leach T, et al,. Long-term clinical experience with vedolizumab in patients with inflammatory bowel disease. Inflamm Bowel Dis 2013; 19: 1691-9.
    • (2013) Inflamm Bowel Dis , vol.19 , pp. 1691-1699
    • Parikh, A.1    Fox, I.2    Leach, T.3
  • 81
    • 84882769357 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for ulcerative colitis
    • Feagan BG, Rutgeerts P, Sands BE, et al,. Vedolizumab as induction and maintenance therapy for ulcerative colitis. N Engl J Med 2013; 369: 699-710.
    • (2013) N Engl J Med , vol.369 , pp. 699-710
    • Feagan, B.G.1    Rutgeerts, P.2    Sands, B.E.3
  • 82
    • 84882749768 scopus 로고    scopus 로고
    • Vedolizumab as induction and maintenance therapy for Crohn's disease
    • Sandborn WJ, Feagan BG, Rutgeerts P, et al,. Vedolizumab as induction and maintenance therapy for Crohn's disease. N Engl J Med 2013; 369: 711-21.
    • (2013) N Engl J Med , vol.369 , pp. 711-721
    • Sandborn, W.J.1    Feagan, B.G.2    Rutgeerts, P.3
  • 84
    • 84879443839 scopus 로고    scopus 로고
    • Vedolizumab induction therapy for patients with Crohn's disease and prior anti-tumour necrosis factor antagonist failure: A randomised, placebo-controlled, double-blind, multicentre trial
    • Sands B, Feagan B, Rutgeerts P, et al,. Vedolizumab induction therapy for patients with Crohn's disease and prior anti-tumour necrosis factor antagonist failure: a randomised, placebo-controlled, double-blind, multicentre trial. J Crohns Colitis 2013; 7 (Suppl. 1): S5-6.
    • (2013) J Crohns Colitis , vol.7 , Issue.SUPPL. 1
    • Sands, B.1    Feagan, B.2    Rutgeerts, P.3
  • 85
    • 84904726322 scopus 로고    scopus 로고
    • Reductions in corticosteroid use in patients with ulcerative colitis or crohn's disease treated with vedolizumab
    • 2013, contribution
    • Sands B, Hanauer S, Colombel JF,. Reductions in corticosteroid use in patients with ulcerative colitis or crohn's disease treated with vedolizumab. 21st United European Gastroenterology Week (UEGWEEK2013), 2013, contribution P887; 2013.
    • (2013) 21st United European Gastroenterology Week (UEGWEEK2013) , pp. 887
    • Sands, B.1    Hanauer, S.2    Colombel, J.F.3
  • 87
    • 84886314228 scopus 로고    scopus 로고
    • Integrated safety analysis of Vedolizumab for the treatment of ulcerative colitis or Crohn's disease
    • DDW 2013
    • Colombel JF, Sands B, Feagan BG, et al,. Integrated safety analysis of Vedolizumab for the treatment of ulcerative colitis or Crohn's disease. DDW 2013. Gastroenterology 2013; 144 (Suppl. 1): S-113.
    • (2013) Gastroenterology , vol.144 , Issue.SUPPL. 1
    • Colombel, J.F.1    Sands, B.2    Feagan, B.G.3
  • 88
    • 84876269569 scopus 로고    scopus 로고
    • Pharmacology of AMG 181, a human anti-α4 β7 antibody that specifically alters trafficking of gut-homing T cells
    • Pan WJ, Hsu H, Rees WA, et al,. Pharmacology of AMG 181, a human anti-α4 β7 antibody that specifically alters trafficking of gut-homing T cells. Br J Pharmacol 2013; 169: 51-68.
    • (2013) Br J Pharmacol , vol.169 , pp. 51-68
    • Pan, W.J.1    Hsu, H.2    Rees, W.A.3
  • 89
    • 84894544868 scopus 로고    scopus 로고
    • Clinical pharmacology and safety of AMG 181, a human anti-α4β7 antibody for treating inflammatory bowel diseases
    • 2013, contribution P914
    • Pan WJ, Sullivan B, Rees W, et al,. Clinical pharmacology and safety of AMG 181, a human anti-α4β7 antibody for treating inflammatory bowel diseases. 21st United European Gastroenterology Week (UEGWEEK2013), 2013, contribution P914; 2013.
    • (2013) 21st United European Gastroenterology Week (UEGWEEK2013)
    • Pan, W.J.1    Sullivan, B.2    Rees, W.3
  • 90
    • 84894515265 scopus 로고    scopus 로고
    • Safety, pharmacology, and effect of AMG 181, a human anti-α4β7 antibody, in subjects with mild to moderate ulcerative colitis
    • 2013, contribution OP264
    • Pan WJ, Radford-Smith G, Andrews J, et al,. Safety, pharmacology, and effect of AMG 181, a human anti-α4β7 antibody, in subjects with mild to moderate ulcerative colitis. 21st United European Gastroenterology Week (UEGWEEK2013) 2013, contribution OP264; 2013.
    • (2013) 21st United European Gastroenterology Week (UEGWEEK2013)
    • Pan, W.J.1    Radford-Smith, G.2    Andrews, J.3
  • 94
    • 84894514599 scopus 로고    scopus 로고
    • ClinicalTrials.gov. NCT01696396. Accessed November 26, 2013
    • ClinicalTrials.gov. AMG 181 in subjects with moderate to severe Crohn's disease. NCT01696396. Available at: http://clinicaltrials.gov/show/NCT01696396. Accessed November 26, 2013.
    • AMG 181 in Subjects with Moderate to Severe Crohn's Disease
  • 95
    • 79953067215 scopus 로고    scopus 로고
    • A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes
    • Stefanich EG, Danilenko DM, Wang H, et al,. A humanized monoclonal antibody targeting the β7 integrin selectively blocks intestinal homing of T lymphocytes. Br J Pharmacol 2011; 162: 1855-70.
    • (2011) Br J Pharmacol , vol.162 , pp. 1855-1870
    • Stefanich, E.G.1    Danilenko, D.M.2    Wang, H.3
  • 96
    • 84880254401 scopus 로고    scopus 로고
    • A randomised phase i study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis
    • Rutgeerts PJ, Fedorak RN, Hommes DW, et al,. A randomised phase I study of etrolizumab (rhuMAb β7) in moderate to severe ulcerative colitis. Gut 2013; 62: 1122-30.
    • (2013) Gut , vol.62 , pp. 1122-1130
    • Rutgeerts, P.J.1    Fedorak, R.N.2    Hommes, D.W.3
  • 97
    • 84894535990 scopus 로고    scopus 로고
    • Differentiation between etrolizumab (Rhumab Beta7) and placebo in the eucalyptus Phase II randomized double-blind placebo-controlled induction study to evaluate efficacy and safety in patients with refractory moderate-to-severely active ulcerative colitis
    • Digestive Diseases Week 2013
    • Vermeire S, O'Byrne S, Williams S, et al,. Differentiation between etrolizumab (Rhumab Beta7) and placebo in the eucalyptus Phase II randomized double-blind placebo-controlled induction study to evaluate efficacy and safety in patients with refractory moderate-to-severely active ulcerative colitis. Digestive Diseases Week 2013. Gastroenterology 2013; 144 (Suppl. 1): S-36.
    • (2013) Gastroenterology , vol.144 , Issue.SUPPL. 1
    • Vermeire, S.1    O'Byrne, S.2    Williams, S.3
  • 99
    • 29244458849 scopus 로고    scopus 로고
    • Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis
    • Farkas S, Hornung M, Sattler C, et al,. Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis. Int J Colorectal Dis 2006; 21: 71-8.
    • (2006) Int J Colorectal Dis , vol.21 , pp. 71-78
    • Farkas, S.1    Hornung, M.2    Sattler, C.3
  • 100
    • 79960336916 scopus 로고    scopus 로고
    • The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: A randomised study
    • Vermeire S, Ghosh S, Panes J, et al,. The mucosal addressin cell adhesion molecule antibody PF-00547,659 in ulcerative colitis: a randomised study. Gut 2011; 60: 1068-75.
    • (2011) Gut , vol.60 , pp. 1068-1075
    • Vermeire, S.1    Ghosh, S.2    Panes, J.3
  • 105
    • 84884816010 scopus 로고    scopus 로고
    • Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice
    • Sugiura T, Kageyama S, Andou A, et al,. Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. J Crohns Colitis 2013; 7: e533-42.
    • (2013) J Crohns Colitis , vol.7
    • Sugiura, T.1    Kageyama, S.2    Andou, A.3
  • 106
    • 79955562875 scopus 로고    scopus 로고
    • Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: A randomized, double-blind, placebo-controlled trial
    • Takazoe M, Watanabe M, Kawaguchi T, et al,. Oral alpha-4 integrin inhibitor (AJM300) in patients with active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Gastroenterology 2009; 136 (Suppl. 1): A-181.
    • (2009) Gastroenterology , vol.136 , Issue.SUPPL. 1
    • Takazoe, M.1    Watanabe, M.2    Kawaguchi, T.3
  • 107
    • 0031782392 scopus 로고    scopus 로고
    • A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease
    • Yacyshyn BR, Bowen-Yacyshyn MB, Jewell L, et al,. A placebo-controlled trial of ICAM-1 antisense oligonucleotide in the treatment of Crohn's disease. Gastroenterology 1998; 114: 1133-42.
    • (1998) Gastroenterology , vol.114 , pp. 1133-1142
    • Yacyshyn, B.R.1    Bowen-Yacyshyn, M.B.2    Jewell, L.3
  • 108
    • 0036288638 scopus 로고    scopus 로고
    • Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease
    • Yacyshyn BR, Chey WY, Goff J, et al,. Double blind, placebo controlled trial of the remission inducing and steroid sparing properties of an ICAM-1 antisense oligodeoxynucleotide, alicaforsen (ISIS 2302), in active steroid dependent Crohn's disease. Gut 2002; 51: 30-6.
    • (2002) Gut , vol.51 , pp. 30-36
    • Yacyshyn, B.R.1    Chey, W.Y.2    Goff, J.3
  • 109
    • 0035045185 scopus 로고    scopus 로고
    • Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease
    • Schreiber S, Nikolaus S, Malchow H, et al,. Absence of efficacy of subcutaneous antisense ICAM-1 treatment of chronic active Crohn's disease. Gastroenterology 2001; 120: 1339-46.
    • (2001) Gastroenterology , vol.120 , pp. 1339-1346
    • Schreiber, S.1    Nikolaus, S.2    Malchow, H.3
  • 110
    • 7244252832 scopus 로고    scopus 로고
    • A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis
    • Van Deventer SJ, Tami JA, Wedel MK,. A randomised, controlled, double blind, escalating dose study of alicaforsen enema in active ulcerative colitis. Gut 2004; 53: 1646-51.
    • (2004) Gut , vol.53 , pp. 1646-1651
    • Van Deventer, S.J.1    Tami, J.A.2    Wedel, M.K.3
  • 111
    • 33646237136 scopus 로고    scopus 로고
    • Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis
    • Miner PB, Geary RS, Matson J, et al,. Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis. Aliment Pharmacol Ther 2006; 23: 1427-34.
    • (2006) Aliment Pharmacol Ther , vol.23 , pp. 1427-1434
    • Miner, P.B.1    Geary, R.S.2    Matson, J.3
  • 112
    • 77954179519 scopus 로고    scopus 로고
    • Anti-adhesion molecule therapy for inflammatory bowel disease
    • Ghosh S, Panaccione R,. Anti-adhesion molecule therapy for inflammatory bowel disease. Therap Adv Gastroenterol 2010; 3: 239-58.
    • (2010) Therap Adv Gastroenterol , vol.3 , pp. 239-258
    • Ghosh, S.1    Panaccione, R.2
  • 113
    • 33750716541 scopus 로고    scopus 로고
    • Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis
    • Rivera-Nieves J, Ho J, Bamias G, et al,. Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis. Gastroenterology 2006; 131: 1518-29.
    • (2006) Gastroenterology , vol.131 , pp. 1518-1529
    • Rivera-Nieves, J.1    Ho, J.2    Bamias, G.3
  • 114
    • 77957244016 scopus 로고    scopus 로고
    • Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease
    • Walters MJ, Wang Y, Lai N, et al,. Characterization of CCX282-B, an orally bioavailable antagonist of the CCR9 chemokine receptor, for treatment of inflammatory bowel disease. J Pharmacol Exp Ther 2010; 335: 61-9.
    • (2010) J Pharmacol Exp Ther , vol.335 , pp. 61-69
    • Walters, M.J.1    Wang, Y.2    Lai, N.3
  • 115
    • 84875195096 scopus 로고    scopus 로고
    • A randomized controlled trial of the efficacy and safety of CCX282-B, an orally-administered blocker of chemokine receptor CCR9, for patients with Crohn's disease
    • Keshav S, Vaňásek T, Niv Y, et al,. A randomized controlled trial of the efficacy and safety of CCX282-B, an orally-administered blocker of chemokine receptor CCR9, for patients with Crohn's disease. PLoS ONE 2013; 8: e60094.
    • (2013) PLoS ONE , vol.8
    • Keshav, S.1    Vaňásek, T.2    Niv, Y.3
  • 117
    • 75149116327 scopus 로고    scopus 로고
    • The second European evidence-based consensus on the diagnosis and management of Crohn's disease: Special situations
    • Van Assche G, Dignass A, Reinisch W, et al,. The second European evidence-based consensus on the diagnosis and management of Crohn's disease: special situations. J Crohns Colitis 2010; 4: 63-101.
    • (2010) J Crohns Colitis , vol.4 , pp. 63-101
    • Van Assche, G.1    Dignass, A.2    Reinisch, W.3
  • 118
    • 38749149901 scopus 로고    scopus 로고
    • European evidence-based consensus on the management of ulcerative colitis: Special situations
    • Biancone L, Michetti P, Travis S, et al,. European evidence-based consensus on the management of ulcerative colitis: special situations. J Crohns Colitis 2008; 2: 63-92.
    • (2008) J Crohns Colitis , vol.2 , pp. 63-92
    • Biancone, L.1    Michetti, P.2    Travis, S.3
  • 119
    • 0035661708 scopus 로고    scopus 로고
    • Gut mucosal T cell lines from ankylosing spondylitis patients are enriched with alphaEbeta7 integrin
    • Van Damme N, Elewaut D, Baeten D, et al,. Gut mucosal T cell lines from ankylosing spondylitis patients are enriched with alphaEbeta7 integrin. Clin Exp Rheumatol 2001; 19: 681-7.
    • (2001) Clin Exp Rheumatol , vol.19 , pp. 681-687
    • Van Damme, N.1    Elewaut, D.2    Baeten, D.3
  • 120
    • 0034108541 scopus 로고    scopus 로고
    • Subclinical gut inflammation in spondyloarthropathy patients is associated with upregulation of the E-cadherin/catenin complex
    • Demetter P, Baeten D, De Keyser F, et al,. Subclinical gut inflammation in spondyloarthropathy patients is associated with upregulation of the E-cadherin/catenin complex. Ann Rheum Dis 2000; 59: 211-16.
    • (2000) Ann Rheum Dis , vol.59 , pp. 211-216
    • Demetter, P.1    Baeten, D.2    De Keyser, F.3
  • 121
    • 0037065563 scopus 로고    scopus 로고
    • Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease
    • Grant AJ, Lalor PF, Salmi M, Jalkanen S, Adams DH,. Homing of mucosal lymphocytes to the liver in the pathogenesis of hepatic complications of inflammatory bowel disease. Lancet 2002; 359: 150-7.
    • (2002) Lancet , vol.359 , pp. 150-157
    • Grant, A.J.1    Lalor, P.F.2    Salmi, M.3    Jalkanen, S.4    Adams, D.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.