Influence of NFκB inhibitors on IL-1β-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: Glucocorticoid ineffectiveness and paradoxical effect of PDTC

International Journal of Colorectal Disease

Volumn 25, Issue 3, 2010, Pages 323-333

  Sunil, Yeruva ^a,b   Ramadori, Giuliano ^a   Raddatz, Dirk ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

CXCL10; CXCL8; Intestinal epithelial cells; NF B; PDTC

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALKALINE PHOSPHATASE; DEXAMETHASONE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 8; PYRROLIDINE DITHIOCARBAMATE; 3-(4-METHYLPHENYLSULFONYL)-2-PROPENENITRILE; CXCL10 PROTEIN, HUMAN; FLAVONOID; IL8 PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; MESSENGER RNA; NITRILE; PYRIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; PYRROLIDINE DITHIOCARBAMIC ACID; SULFONE; THIOCARBAMIC ACID DERIVATIVE;

ARTICLE; CELL STRAIN CACO 2; CELL STRAIN HT29; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; INTESTINE; METABOLISM; REPORTER GENE; SECRETION;

CACO-2 CELLS; CHEMOKINE CXCL10; DEXAMETHASONE; EPITHELIAL CELLS; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GLUCOCORTICOIDS; HT29 CELLS; HUMANS; IMIDAZOLES; INTERLEUKIN-1BETA; INTERLEUKIN-8; INTESTINES; NF-KAPPA B; NITRILES; PYRIDINES; PYRROLIDINES; RECEPTORS, GLUCOCORTICOID; RNA, MESSENGER; SULFONES; THIOCARBAMATES;

EID: 77649234852     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-009-0847-3     Document Type: Article

References (32)

1. E Voss J Wehkamp K Wehkamp EF Stange JM Schroder J Harder 2006 NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2 J Biol Chem 281 2005 2011 10.1074/jbc.M511044200 16319062 (Pubitemid 43845788)
2. G Rogler K Brand D Vogl S Page R Hofmeister T Andus R Knuechel PA Baeuerle J Scholmerich V Gross 1998 Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa Gastroenterology 115 357 369 10.1016/S0016-5085(98)70202-1 9679041 (Pubitemid 28363428)
3. M Grilli JJ Chiu MJ Lenardo 1993 NF-kappa B and Rel: participants in a multiform transcriptional regulatory system Int Rev Cytol 143 1 62 10.1016/S0074-7696(08)61873-2 8449662
4. AS Baldwin Jr 1996 The NF-kappa B and I kappa B proteins: new discoveries and insights Annu Rev Immunol 14 649 683 10.1146/annurev.immunol.14.1.649 8717528 (Pubitemid 26130197)
5. SM Ruben R Narayanan JF Klement CH Chen CA Rosen 1992 Functional characterization of the NF-kappa B p65 transcriptional activator and an alternatively spliced derivative Mol Cell Biol 12 444 454 1732726
6. KA Roebuck 1999 Regulation of interleukin-8 gene expression J Interferon Cytokine Res 19 429 438 10.1089/107999099313866 10386854 (Pubitemid 29269932)
7. S Yeruva G Ramadori D Raddatz 2008 NF-kappaB-dependent synergistic regulation of CXCL10 gene expression by IL-1beta and IFN-gamma in human intestinal epithelial cell lines Int J Colorectal Dis 23 305 317 10.1007/s00384-007-0396-6 18046562
8. S Struyf M Gouwy C Dillen P Proost G Opdenakker J Van Damme 2005 Chemokines synergize in the recruitment of circulating neutrophils into inflamed tissue Eur J Immunol 35 1583 1591 10.1002/eji.200425753 15827963 (Pubitemid 40703864)
9. RD Fusunyan JJ Quinn Y Ohno RP MacDermott IR Sanderson 1998 Butyrate enhances interleukin (IL)-8 secretion by intestinal epithelial cells in response to IL-1beta and lipopolysaccharide Pediatr Res 43 84 90 10.1203/00006450- 199801000-00013 9432117
10. H Kim JW Lim KH Kim 2001 Helicobacter pylori-induced expression of interleukin-8 and cyclooxygenase-2 in AGS gastric epithelial cells: mediation by nuclear factor-kappaB Scand J Gastroenterol 36 706 716 10.1080/ 003655201300191969 11444469
11. C Banks A Bateman R Payne P Johnson N Sheron 2003 Chemokine expression in IBD. Mucosal chemokine expression is unselectively increased in both ulcerative colitis and Crohn's disease J Pathol 199 28 35 10.1002/path.1245 12474223 (Pubitemid 36054726)
12. M Loetscher B Gerber P Loetscher SA Jones L Piali I Clark-Lewis M Baggiolini B Moser 1996 Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes J Exp Med 184 963 969 10.1084/jem.184.3.963 9064356
13. P Proost E Schutyser P Menten S Struyf A Wuyts G Opdenakker M Detheux M Parmentier C Durinx AM Lambeir J Neyts S Liekens PC Maudgal A Billiau J Van Damme 2001 Amino-terminal truncation of CXCR3 agonists impairs receptor signaling and lymphocyte chemotaxis, while preserving antiangiogenic properties Blood 98 3554 3561 10.1182/blood.V98.13.3554 11739156
14. MB Dwinell N Lugering L Eckmann MF Kagnoff 2001 Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells Gastroenterology 120 49 59 10.1053/gast.2001.20914 11208713
15. N Auphan JA DiDonato C Rosette A Helmberg M Karin 1995 Immunosupression by glucocorticoids: inhibition of NFkB activity through induction of IkB synthesis Science 270 286 289 10.1126/science.270.5234.286 7569976
16. YR Mahida K Wu DP Jewell 1989 Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease Gut 30 835 838 10.1136/gut.30.6.835 2787769 (Pubitemid 19167787)
17. D Raddatz M Bockemuhl G Ramadori 2005 Quantitative measurement of cytokine mRNA in inflammatory bowel disease: relation to clinical and endoscopic activity and outcome Eur J Gastroenterol Hepatol 17 547 557 10.1097/00042737-200505000-00012 15827446 (Pubitemid 40592713)
18. D Raddatz P Middel M Bockemuhl P Benohr C Wissmann H Schworer G Ramadori 2004 Glucocorticoid receptor expression in inflammatory bowel disease: evidence for a mucosal down-regulation in steroid-unresponsive ulcerative colitis Aliment Pharmacol Ther 19 47 61 10.1046/j.1365-2036.2003.01802.x 14687166 (Pubitemid 38125637)
19. E Caldenhoven J Liden S Wissink A Van de Stolpe J Raaijmakers L Koenderman S Okret JA Gustafsson PT Van der Saag 1995 Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids Mol Endocrinol 9 401 412 10.1210/me.9.4.401 7659084
20. D Raddatz S Toth H Schworer G Ramadori 2001 Glucocorticoid receptor signaling in the intestinal epithelial cell lines IEC-6 and Caco-2: evidence of inhibition by interleukin-1beta Int J Colorectal Dis 16 377 383 10.1007/s003840100331 11760899 (Pubitemid 33062013)
21. H Bantel ML Schmitz A Raible M Gregor K Schulze-Osthoff 2002 Critical role of NF-kappaB and stress-activated protein kinases in steroid unresponsiveness FASEB J 16 1832 1834 12223450
22. LJ Egan DC Mays CJ Huntoon MP Bell MG Pike WJ Sandborn JJ Lipsky DJ McKean 1999 Inhibition of interleukin-1-stimulated NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity J Biol Chem 274 26448 26453 10.1074/jbc.274.37.26448 10473604 (Pubitemid 29437098)
23. C Jobin S Haskill L Mayer A Panja RB Sartor 1997 Evidence for altered regulation of I kappa B alpha degradation in human colonic epithelial cells J Immunol 158 226 234 8977194
24. T Yokoo M Kitamura 1996 Antioxidant PDTC induces stromelysin expression in mesangial cells via a tyrosine kinase-AP-1 pathway Am J Physiol 270 F806 F811 8928842
25. C Munoz MC Castellanos A Alfranca A Vara MA Esteban JM Redondo MO de Landazuri 1996 Transcriptional up-regulation of intracellular adhesion molecule-1 in human endothelial cells by the antioxidant pyrrolidine dithiocarbamate involves the activation of activating protein-1 J Immunol 157 3587 3597 8871659
26. SK Moon SY Jung YH Choi YC Lee C Patterson CH Kim 2004 PDTC, metal chelating compound, induces G1 phase cell cycle arrest in vascular smooth muscle cells through inducing p21Cip1 expression: involvement of p38 mitogen activated protein kinase J Cell Physiol 198 310 323 10.1002/jcp.10728 14603533 (Pubitemid 38133964)
27. K Parhar A Ray U Steinbrecher C Nelson B Salh 2003 The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells Immunology 108 502 512 10.1046/j.1365-2567.2003.01603.x 12667212 (Pubitemid 36469688)
28. H Holtmann R Winzen P Holland S Eickemeier E Hoffmann D Wallach NL Malinin JA Cooper K Resch M Kracht 1999 Induction of interleukin-8 synthesis integrates effects on transcription and mRNA degradation from at least three different cytokine- or stress-activated signal transduction pathways Mol Cell Biol 19 6742 6753 10490613
29. YD Jung F Fan DJ McConkey ME Jean W Liu N Reinmuth O Stoeltzing SA Ahmad AA Parikh N Mukaida LM Ellis 2002 Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells Cytokine 18 206 213 10.1006/cyto.2002.1034 12126643 (Pubitemid 34775429)
30. MY Stoeckle 1991 Post-transcriptional regulation of gro alpha, beta, gamma, and IL-8 mRNAs by IL-1 beta Nucleic Acids Res 19 917 920 10.1093/nar/19.4.917 2017372
31. A Nenci C Becker A Wullaert R Gareus G van Loo S Danese M Huth A Nikolaev C Neufert B Madison D Gumucio MF Neurath M Pasparakis 2007 Epithelial NEMO links innate immunity to chronic intestinal inflammation Nature 446 557 561 10.1038/nature05698 17361131 (Pubitemid 46514732)
32. FR Greten L Eckmann TF Greten JM Park ZW Li LJ Egan MF Kagnoff M Karin 2004 IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer Cell 118 285 296 10.1016/j.cell.2004.07.013 15294155 (Pubitemid 39061110)