β-conglycinin reduces the tight junction occludin and ZO-1 expression in IPEC-J2

International Journal of Molecular Sciences

Volumn 15, Issue 2, 2014, Pages 1915-1926

  Zhao, Yuan ^a   Qin, Guixin ^a   Han, Rui ^a   Wang, Jun ^a   Zhang, Xiaodong ^b   Liu, Dandan ^a  

^a JILIN AGRICULTURAL UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

Author keywords

Food allergen; Intestinal barrier; IPEC J2; Tight junction; conglycinin

Indexed keywords

ALKALINE PHOSPHATASE; BETA CONGLYCININ; FOOD ALLERGEN; OCCLUDIN; PROTEIN ZO1; UNCLASSIFIED DRUG; BETA-CONGLYCININ PROTEIN, GLYCINE MAX; GLOBULIN; MESSENGER RNA; PLANT ANTIGEN; SEED STORAGE PROTEIN; SOYBEAN PROTEIN; VEGETABLE PROTEIN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; ELECTRIC RESISTANCE; ENZYME ACTIVITY; GENE EXPRESSION; IMMUNOFLUORESCENCE TEST; METABOLIC ACTIVATION; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA EXTRACTION; SWINE; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MEMBRANE POTENTIAL; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; TIGHT JUNCTION;

ANIMALS; ANTIGENS, PLANT; CELL LINE; CELL MEMBRANE PERMEABILITY; GENE EXPRESSION REGULATION; GLOBULINS; MEMBRANE POTENTIALS; METABOLIC NETWORKS AND PATHWAYS; OCCLUDIN; PLANT PROTEINS; PROTEIN TRANSPORT; RNA, MESSENGER; SEED STORAGE PROTEINS; SOYBEAN PROTEINS; SWINE; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84893068817     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15021915     Document Type: Article

References (46)

1. Friedman, M.; Brandon, D.L. Nutritional and health benefits of soy proteins. J. Agric. Food Chem. 2001, 49, 1069-1086.
2. Ogawa, T.; Bando, N.; Tsuji, H.; Nishikawa, K.; Kitamura, K. Alpha-subunit of β-conglycinin, an allergenic protein recognized by IgE antibodies of soybean-sensitive patients with atopic-dermatitis. Biosci. Biotechnol. Biochem. 1995, 59, 831-833.
3. Krishnan, H.B.; Kim W.S.; Jang, S.; Kerley, M.S. All three subunits of soybean β-conglycinin are potential food allergens. J. Agric. Food Chem. 2009, 57, 938-943.
4. Hao, Y.; Zhan, Z.F.; Guo, P.F.; Piao, X.S.; Li, D.F. Soybean β-conglycinin-induced gut hypersensitivity reaction in a piglet model. Arch. Anim. Nutr. 2009, 63, 188-202.
5. Mariani, V.; Palermo, S.; Fiorentini, S.; Lanubile, A.; Giuffra, E. Gene expression study of two widely used pig intestinal epithelial cell lines: IPEC-J2 and IPI-2I. Vet. Immunol. Immunopathol. 2009, 131, 278-284.
6. Pitman, R.S.; Blumberg, R.S. First line of defense: The role of the intestinal epithelium as an active component of the mucosal immune system. J. Gastroenterol. 2000, 35, 805-814.
7. Zheng, S.G. The Identification of Potential Allergenic Subunits and Epitope-containing Peptide Fragments in Soybean Protein Glycinin and β-Conglycinin. Ph.D. Thesis, Jilin Agricultural University, Changchun, China, 2009.
8. Adachi, A.; Horikawa, T.; Shimizu, H.; Sarayama, Y.; Ogawa, T.; Sjolander, S.; Tanaka, A.; Moriyama, T. Soybean β-conglycinin as the main allergen in a patient with food-dependent exercise-induced anaphylaxis by tofu: Food processing alters pepsin resistance. Clin. Exp. Allergy 2009, 39, 167-173.
9. Lallès, J.P.; Tukur, H.M.; Salgado, P.; Mills, C.E.N.; Morgan, M.R.A.; Quillien, L.; Levieux, D.; Toullec, R. Immunochemical studies on gastric and intestinal digestion of soybean glycinin and β-conglycinin in vivo. J. Agric. Food Chem. 1999, 47, 2797-2806.
10. Wang, T.; Qin, G.X.; Zhao, Y.; Sun, Z.W. Comparative study on the stability of soybean (Glycine max) β-conglycinin in vivo. Food Agric. Immunol. 2009, 20, 295-304.
11. Zhao, Y.; Qin, G.X.; Sun, Z.W.; Zhang, B.; Wang, T. Stability and immunoreactivity of glycinin and β-conglycinin to hydrolysis in vitro. Food Agric. Immunol. 2010b, 21, 253-263.
12. Astwood, J.D.; Leach, J.N.; Fuchs, R.L. Stability of food allergens to digestion in vitro. Nat. Biotechnol. 1996, 14, 1269-1273.
13. Moreno, F.J.; Clemente, A. 2S albumin storage proteins: What makes them food allergens? Open Biochem. J. 2008, 2, 16-28.
14. Dunsford, B.R.; Knabe, D.A.; Hanesly, W.E. Effect of dietary soybean meal on the microscopic anatomy of the small intestine in the early weaned pigs. J. Anim. Sci. 1989, 67, 1855-1863.
15. Li, D.; Nelssen, J.L.; Reddy, P.G.; Belcha, F.; Hancock, J.D.; Allee, G.L.; Goodband, R.D. Transient hypersensitivity to soybean meal in the early-weaned pig. J. Anim. Sci. 1990, 68, 1790-1799.
16. Qin, G.X.; Xu, L.M.; Jiang, H.L.; van der Poel, A.F.B.; Bosch, M.W.; Verstegen, M.W.A. The effect of Chinese and Argentine soybeans on nutrient digestibility and organ morphology in Landrace and Chinese Min pigs. Asian Aust. J. Anim. Sci. 2002, 15, 555-564.
17. Qiao, S.; Li, D.; Jiang, J.; Zhou, H.; Li, J.; Thacker, P. Effects of moist extruded full-fat soybeans on Gut morphology and mucosal cell turnover time of weanling pigs. Asian Aust. J. Anim. Sci. 2003, 16, 63-69.
18. Zhao, Y.; Qin, G.X.; Sun, Z.W.; Zhang, B.; Wang, T. Effects of glycinin and β-conglycinin on enterocyte apoptosis, proliferation and migration of piglets. Food Agric. Immunol. 2010, 21, 209-218.
19. Miller, E.R.; Ullrey, D.E. The pig as a model for human nutrition. Annu. Rev. Nutr. 1987, 7, 361-382.
20. Khatri, M.; Dwivedi, V.; Krakowka, S.; Manickam, C.; Ali, A.; Wang, L.; Qin, Z.M.; Renukaradhya, G.J.; Lee, C.W. Swine influenza H1N1 virus induces acute inflammatory Immune responses in pig lungs: A potential animal model for human H1N1 influenza virus. J. Virol. 2010, 84, 11210-11218.
21. Hinnebusch, B.F.; Siddique, W.; Henderson, W.; Malo, M.S.; Zhang, W.; Athaide, C.P.; Abedrapo, M.A.; Chen, X.; Yang, V.W.; Hodin, R.A. Enterocyte differentiation marker intestinal alkaline phosphatase is a target gene of the gut-enriched Krüppel-like factor. Am. J. Physiol. Gastrointest. Liver Physiol. 2004, 286, G23-G30.
22. Sampson, H.A. Allergy clinical immunology disorders. J. Allergy Clin. Immunol. 1999, 103, 717-728.
23. Venter, C.; Pereira, B.; Voigt, K.; Grundy, J.; Clayton, C.B.; Higgins, B.; Arshad, S.H.; Dean, T. Prevalence and cumulative incidence of food hypersensitivity in the first 3 years of life. Allergy 2008, 6, 354-359.
24. Tanabe, S. Epitope peptides and immunotherapy. Curr. Protein Pept. Sci. 2007, 8, 109-118.
25. Heyman, M.; Ducroc, R.; Desjeux, J.F.; Morgat, J.L. Horseradish peroxidase transport across adult rabbit jejunum in vitro. Am. J. Physiol. 1982, 242, 558-564.
26. Fujita, M.; Reinhart, F.; Neutra, M. Convergence of apical and basolateral endocytic pathways at apical late endosomes in absorptive cells of suckling rat ileum in vivo. J. Cell Sci. 1990, 97, 385-394.
27. Laiping, S.A.; Pelton-Henrion, K.; Small, G.; Becker, K.; Oei, E.; Tyorkin, M.; Sperber, K.; Mayer, L. Antigen uptake and trafficking in human intestinal epithelial cells. Dig. Dis. Sci. 2000, 45, 1451-1461.
28. Yu, L.C.H. The epithelial gatekeeper against food allergy. Pediatr. Neonatol. 2009, 50, 247-254.
29. Berin, M.C.; Kiliaan, A.J.; Yang, P.C.; Groot, J.A.; Kitamura, Y.; Perdue, M.H. The influence of mast cells on pathways of transepithelial antigen transport in rat intestine. J. Immunol. 1998, 161, 2561-2566.
30. Yu, L.C.H.; Yang, P.C.; Berin, M.C.; Di Leo, V.; Conrad, D.H.; McKay, D.M.; Satoskar, A.R.; Perdue, M.H. Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4. Gastroenterology 2001, 121, 370-381.
31. André, C.; André, F.; Colin, N.; Cavagna, S. Measurement of intestinal permeability to mannitol and lactulose as a means of diagnosing food allergy and evaluating therapeutic effectiveness of sodium cromoglycate. Ann. Allergy 1987, 59, 127-130.
32. Ventura, M.T.; Polimeno, L.; Amoruso, A.C. Intestinal permeability in patients with adverse reactions to food. Dig. Liver Dis. 2006, 38, 732-736.
33. Song, D.J.; Cho, J.Y.; Miller, M. Anti-Siglec-F antibody inhibits oral egg allergen induced intestinal eosinophilic inflammation in a mouse model. Clin. Immunol. 2009, 131, 157-169.
34. Perrier, C.; Corthésy, B. Gut permeability and food allergies. Clin. Exp. Allergy 2011, 41, 20-28.
35. Hidalgo, I.J.; Raub, T.J.; Borchardt, R.T. Characterization of the human colon carcinoma cell line (Caco-2) as a model system for intestinal epithelial permeability. Gastroenterology 1989, 96, 736-749.
36. Wilson, G.; Hassan, I.F.; Dix, C.J.; Williamson, R.; Shah, R.; Mackey, M.; Artursson, P. Transport and permeability properties of human Caco-2 cells: An in vitro model of the intestinal epithelial cell barrier. J. Control Release 1990, 11, 25-40.
37. Pellegrina, C.D.; Rizzi, C.; Mosconi, S.; Zoccatelli, G.; Peruffo, A.; Chignola, R. Plant lectin as carriers for oral drugs: Is wheat germ agglutinin a suitable candidate? Toxicol. Appl. Pharm. 2005, 207, 170-178.
38. Xu, J.; Zhou, A.; Wang, Z.; Ai, D. Effects of glycinin and β-conglycinin on integrity and immune responses of mouse intestinal epithelial cells. J. Anim. Plant Sci. 2010, 20, 170-174.
39. Kenworthy, R. Observations on the effects of weaning in the young pigs: Clinical and histopathological studies of intestinal function and morphology. Res. Vet. Sci. 1976, 21, 69-75.
40. Bates, J.M.; Akerlund, J.; Mittge, E.; Guillemin, K. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in zebrafish in response to the gut microbiota. Cell Host Microbe 2007, 2, 371-382.
41. Geddes, K.; Philpott, D.J. A new role for intestinal alkaline phosphatase in gut barrier maintenance. Gastroenterology 2008, 135, 8-12.
42. Yosbida, Y.; Ban, Y.; Kinosbita, S. Tight junction transmembrane protein claudin subtype expression and distribution in human corneal and conjunctival epithelium. Investig. Ophthalmol. Vis. Sci. 2009, 50, 2103-2108.
43. Yu, A.S.; McCarthy, K.M.; Francis, S.A.; McCormack, J.M.; Lai, J.; Rogers, R.A.; Lynch, R.D.; Schneeberger, E.E. Knockdown of occludin expression leads to diverse phenotypic alterations in epithelial cells. Am. J. Physiol. Cell Physiol. 2005, 288, C1231-C1241.
44. Zhao, J.H.; Wang, J.H.; Dong, L.; Shi, H.; Wang, Z.; Ding, H.; Shi, H.; Lu, X. A protease inhibitor against acute stress-induced visceral hypersensitivity and paracellular permeability in rats. Eur. J. Pharmacol. 2011, 654, 289-294.
45. Groschwitz, K.R.; Hogan, S.P. Intestinal barrier function: Molecular regulation and disease pathogenesis. J. Allergy Clin. Immunol. 2009, 124, 3-20.
46. Setsuko, I.; Fumio, Y. Determination of glycinin and β-conglycinin in soybean protein by immunological methods. Agric. Food Chem. 1987, 35, 200-205.