Hepatotoxic effects of (tri)azole fungicides in a broad dose range

Archives of Toxicology

Volumn 89, Issue 11, 2015, Pages 2105-2117

  Heise, T ^a   Schmidt, F ^a   Knebel, C ^a   Rieke, S ^a   Haider, W ^b   Pfeil, R ^a   Kneuer, C ^a   Niemann, L ^a   Marx Stoelting, P ^a  

^a FEDERAL INSTITUTE FOR RISK ASSESSMENT   (Germany)

^b Institute for Animal Pathology   (Germany)

Author keywords

Adverse outcome pathway; Liver; Low dose; Phenobarbital; Triazole

Indexed keywords

CD36 ANTIGEN; CONSTITUTIVE ANDROSTANE RECEPTOR; CYPROCONAZOLE; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 2B1; CYTOCHROME P450 3A2; EPOXICONAZOLE; FUNGICIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHENOBARBITAL; PROCHLORAZ; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG; CELL RECEPTOR; EPOXIDE; IMIDAZOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FASN GENE; GENE; GENE EXPRESSION; GENE INDUCTION; HISTOPATHOLOGY; LIVER CELL; LIVER TOXICITY; LIVER WEIGHT; MALE; NONHUMAN; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; RAT; WEIGHT GAIN; XENOBIOTIC METABOLISM; ANIMAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENE EXPRESSION REGULATION; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; EPOXY COMPOUNDS; FUNGICIDES, INDUSTRIAL; GENE EXPRESSION REGULATION; HEPATOCYTES; IMIDAZOLES; MALE; PHENOBARBITAL; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRIAZOLES;

EID: 84947577916     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1336-1     Document Type: Article

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