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Volumn 5, Issue , 2015, Pages

GRPR-targeted Protein Contrast Agents for Molecular Imaging of Receptor Expression in Cancers by MRI

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; BOMBESIN RECEPTOR; CONTRAST MEDIUM; LIGAND; PROTEIN BINDING;

EID: 84947556079     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16214     Document Type: Article
Times cited : (23)

References (64)
  • 1
    • 0028103841 scopus 로고
    • Characterization of high-affinity receptors for bombesin/gastrin releasing peptide on the human prostate cancer cell lines PC-3 and DU-145: Internalization of receptor bound 125I-(Tyr4) bombesin by tumor cells
    • Reile, H., Armatis, P. E., Schally, A. V. Characterization of high-affinity receptors for bombesin/gastrin releasing peptide on the human prostate cancer cell lines PC-3 and DU-145: internalization of receptor bound 125I-(Tyr4) bombesin by tumor cells. Prostate 25, 29-38 (1994).
    • (1994) Prostate , vol.25 , pp. 29-38
    • Reile, H.1    Armatis, P.E.2    Schally, A.V.3
  • 2
    • 0036554956 scopus 로고    scopus 로고
    • Bombesin receptor subtypes in human cancers: Detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14)
    • Reubi, J. C., Wenger, S., Schmuckli-Maurer, J., Schaer, J. C., Gugger, M. Bombesin receptor subtypes in human cancers: detection with the universal radioligand (125)I-[D-TYR(6), beta-ALA(11), PHE(13), NLE(14)] bombesin(6-14). Clin Cancer Res 8, 1139-1146 (2002).
    • (2002) Clin Cancer Res , vol.8 , pp. 1139-1146
    • Reubi, J.C.1    Wenger, S.2    Schmuckli-Maurer, J.3    Schaer, J.C.4    Gugger, M.5
  • 3
    • 0032804044 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast
    • Gugger, M., Reubi, J. C. Gastrin-releasing peptide receptors in non-neoplastic and neoplastic human breast. The American journal of pathology 155, 2067-2076 (1999).
    • (1999) The American Journal of Pathology , vol.155 , pp. 2067-2076
    • Gugger, M.1    Reubi, J.C.2
  • 4
    • 0033104343 scopus 로고    scopus 로고
    • Gastrin-releasing peptide receptors in the human prostate: Relation to neoplastic transformation
    • Markwalder, R., Reubi, J. C. Gastrin-releasing peptide receptors in the human prostate: relation to neoplastic transformation. Cancer research 59, 1152-1159 (1999).
    • (1999) Cancer Research , vol.59 , pp. 1152-1159
    • Markwalder, R.1    Reubi, J.C.2
  • 5
    • 41149176081 scopus 로고    scopus 로고
    • Mammalian bombesin receptors: Nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states
    • International Union of Pharmacology. LXVIII
    • Jensen, R. T., Battey, J. F., Spindel, E. R., Benya, R. V. International Union of Pharmacology. LXVIII. Mammalian bombesin receptors: nomenclature, distribution, pharmacology, signaling, and functions in normal and disease states. Pharmacological reviews 60, 1-42 (2008).
    • (2008) Pharmacological Reviews , vol.60 , pp. 1-42
    • Jensen, R.T.1    Battey, J.F.2    Spindel, E.R.3    Benya, R.V.4
  • 6
    • 0037046519 scopus 로고    scopus 로고
    • Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents
    • Achilefu, S. et al. Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents. Journal of medicinal chemistry 45, 2003-2015 (2002).
    • (2002) Journal of Medicinal Chemistry , vol.45 , pp. 2003-2015
    • Achilefu, S.1
  • 7
    • 84876950056 scopus 로고    scopus 로고
    • Near-infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases
    • Cai, Q. Y. et al. Near-infrared fluorescence imaging of gastrin releasing peptide receptor targeting in prostate cancer lymph node metastases. Prostate 73, 842-854 (2013).
    • (2013) Prostate , vol.73 , pp. 842-854
    • Cai, Q.Y.1
  • 8
    • 34247401746 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of Alexa Fluor 680-bombesin[7-14]NH2 peptide conjugate, a high-affinity fluorescent probe with high selectivity for the gastrin-releasing peptide receptor
    • Ma, L. et al. In vitro and in vivo evaluation of Alexa Fluor 680-bombesin[7-14]NH2 peptide conjugate, a high-affinity fluorescent probe with high selectivity for the gastrin-releasing peptide receptor. Molecular imaging 6, 171-180 (2007).
    • (2007) Molecular Imaging , vol.6 , pp. 171-180
    • Ma, L.1
  • 9
    • 33645453313 scopus 로고    scopus 로고
    • Qdot nanocrystal conjugates conjugated to bombesin or ANG II label the cognate G proteincoupled receptor in living cells American journal of physiology
    • Young, S. H., Rozengurt, E. Qdot nanocrystal conjugates conjugated to bombesin or ANG II label the cognate G proteincoupled receptor in living cells. American journal of physiology. Cell physiology 290, C728-732 (2006).
    • (2006) Cell Physiology , vol.290 , pp. C728-732
    • Young, S.H.1    Rozengurt, E.2
  • 10
    • 84866439880 scopus 로고    scopus 로고
    • Molecular imaging and therapeutic efficacy of 188Re-(DXR)-liposome-BBN in AR42J pancreatic tumorbearing mice
    • Chang, Y. J. et al. Molecular imaging and therapeutic efficacy of 188Re-(DXR)-liposome-BBN in AR42J pancreatic tumorbearing mice. Oncology reports 28, 1736-1742 (2012).
    • (2012) Oncology Reports , vol.28 , pp. 1736-1742
    • Chang, Y.J.1
  • 11
  • 12
    • 84886427044 scopus 로고    scopus 로고
    • In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548
    • Kahkonen, E. et al. In vivo imaging of prostate cancer using [68Ga]-labeled bombesin analog BAY86-7548. Clin Cancer Res 19, 5434-5443 (2013).
    • (2013) Clin Cancer Res , vol.19 , pp. 5434-5443
    • Kahkonen, E.1
  • 13
    • 84911968420 scopus 로고    scopus 로고
    • GRP receptor imaging of prostate cancer using [(99m)Tc]Demobesin 4: A first-in-man study. Molecular imaging and biology : B
    • Mather, S. J. et al. GRP receptor imaging of prostate cancer using [(99m)Tc]Demobesin 4: a first-in-man study. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 16, 888-895 (2014).
    • (2014) The Official Publication of the Academy of Molecular Imaging , vol.16 , pp. 888-895
    • Mather, S.J.1
  • 14
    • 0033754433 scopus 로고    scopus 로고
    • Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: A feasibility study
    • Van de Wiele, C. et al. Technetium-99m RP527, a GRP analogue for visualisation of GRP receptor-expressing malignancies: a feasibility study. European journal of nuclear medicine 27, 1694-1699 (2000).
    • (2000) European Journal of Nuclear Medicine , vol.27 , pp. 1694-1699
    • Van De Wiele, C.1
  • 15
    • 0141961858 scopus 로고    scopus 로고
    • 99mTc-bombesin detects prostate cancer and invasion of pelvic lymph nodes
    • Scopinaro, F. et al. 99mTc-bombesin detects prostate cancer and invasion of pelvic lymph nodes. European journal of nuclear medicine and molecular imaging 30, 1378-1382 (2003).
    • (2003) European Journal of Nuclear Medicine and Molecular Imaging , vol.30 , pp. 1378-1382
    • Scopinaro, F.1
  • 16
    • 69349085452 scopus 로고    scopus 로고
    • 177Lu-AMBA Bombesin analogue in hormone refractory prostate cancer patients: A phase i escalation study with single-cycle administrations
    • Bodei, L. et al. 177Lu-AMBA Bombesin analogue in hormone refractory prostate cancer patients: a phase I escalation study with single-cycle administrations. European journal of nuclear medicine and molecular imaging 34, S221 (2007).
    • (2007) European Journal of Nuclear Medicine and Molecular Imaging , vol.34 , pp. S221
    • Bodei, L.1
  • 17
    • 12444338751 scopus 로고    scopus 로고
    • Feasibility of Ga-68-DOTABOM PET in prostate carcinoma patients
    • SPRINGER 233 SPRING STREET, NEW YORK, NY 10013 USA
    • Hofmann, M. et al. Feasibility of Ga-68-DOTABOM PET in prostate carcinoma patients. In European journal of nuclear medicine and molecular imaging, Vol. 31 S253-S253 (SPRINGER 233 SPRING STREET, NEW YORK, NY 10013 USA, 2004).
    • (2004) European Journal of Nuclear Medicine and Molecular Imaging , vol.31 , pp. S253-S253
    • Hofmann, M.1
  • 18
    • 29644443518 scopus 로고    scopus 로고
    • MR imaging and MR spectroscopic imaging in the pre-treatment evaluation of prostate cancer
    • Hricak, H. MR imaging and MR spectroscopic imaging in the pre-treatment evaluation of prostate cancer. The British journal of radiology 78 Spec No 2, S103-111 (2005).
    • (2005) The British Journal of Radiology , vol.78 , Issue.2 , pp. S103-111
    • Hricak, H.1
  • 19
    • 0141731298 scopus 로고    scopus 로고
    • Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging
    • Winter, P. M. et al. Molecular imaging of angiogenesis in nascent Vx-2 rabbit tumors using a novel alpha(nu)beta3-targeted nanoparticle and 1.5 tesla magnetic resonance imaging. Cancer research 63, 5838-5843 (2003).
    • (2003) Cancer Research , vol.63 , pp. 5838-5843
    • Winter, P.M.1
  • 20
    • 33748049106 scopus 로고    scopus 로고
    • Nephrogenic systemic fibrosis: Suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging
    • Marckmann, P. et al. Nephrogenic systemic fibrosis: suspected causative role of gadodiamide used for contrast-enhanced magnetic resonance imaging. Journal of the American Society of Nephrology : JASN 17, 2359-2362 (2006).
    • (2006) Journal of the American Society of Nephrology : JASN , vol.17 , pp. 2359-2362
    • Marckmann, P.1
  • 21
    • 47749116130 scopus 로고    scopus 로고
    • Rational design of protein-based MRI contrast agents
    • Yang, J. J. et al. Rational design of protein-based MRI contrast agents. Journal of the American Chemical Society 130, 9260-9267 (2008).
    • (2008) Journal of the American Chemical Society , vol.130 , pp. 9260-9267
    • Yang, J.J.1
  • 22
    • 84873735836 scopus 로고    scopus 로고
    • Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers. Wiley interdisciplinary reviews
    • Xue, S., Qiao, J., Pu, F., Cameron, M., Yang, J. J. Design of a novel class of protein-based magnetic resonance imaging contrast agents for the molecular imaging of cancer biomarkers. Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 5, 163-179 (2013).
    • (2013) Nanomedicine and Nanobiotechnology , vol.5 , pp. 163-179
    • Xue, S.1    Qiao, J.2    Pu, F.3    Cameron, M.4    Yang, J.J.5
  • 24
    • 84905494725 scopus 로고    scopus 로고
    • Design of ProCAs (protein-based Gd(3+ ) MRI contrast agents) with high dose efficiency and capability for molecular imaging of cancer biomarkers
    • Xue, S. et al. Design of ProCAs (protein-based Gd(3+ ) MRI contrast agents) with high dose efficiency and capability for molecular imaging of cancer biomarkers. Medicinal research reviews 34, 1070-1099 (2014).
    • (2014) Medicinal Research Reviews , vol.34 , pp. 1070-1099
    • Xue, S.1
  • 27
    • 84878748730 scopus 로고    scopus 로고
    • Probing Ca2+-binding capability of viral proteins with the EF-hand motif by grafting approach
    • Zhou, Y., Xue, S., Chen, Y., Yang, J. J. Probing Ca2+-binding capability of viral proteins with the EF-hand motif by grafting approach. Methods in molecular biology 963, 37-53 (2013).
    • (2013) Methods in Molecular Biology , vol.963 , pp. 37-53
    • Zhou, Y.1    Xue, S.2    Chen, Y.3    Yang, J.J.4
  • 28
    • 0026094281 scopus 로고
    • Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells
    • Corjay, M. H. et al. Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. The Journal of biological chemistry 266, 18771-18779 (1991).
    • (1991) The Journal of Biological Chemistry , vol.266 , pp. 18771-18779
    • Corjay, M.H.1
  • 29
    • 33747105269 scopus 로고    scopus 로고
    • 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer
    • Lantry, L. E. et al. 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 47, 1144-1152 (2006).
    • (2006) Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine , vol.47 , pp. 1144-1152
    • Lantry, L.E.1
  • 30
    • 79953065236 scopus 로고    scopus 로고
    • HER2 targeted molecular MR imaging using a de novo designed protein contrast agent
    • Qiao, J. et al. HER2 targeted molecular MR imaging using a de novo designed protein contrast agent. PloS one 6, e18103 (2011).
    • (2011) PloS One , vol.6 , pp. e18103
    • Qiao, J.1
  • 31
    • 76349103926 scopus 로고    scopus 로고
    • The HER2 testing conundrum
    • Allison, M. The HER2 testing conundrum. Nat Biotechnol 28, 117-119 (2010).
    • (2010) Nat Biotechnol , vol.28 , pp. 117-119
    • Allison, M.1
  • 32
    • 36049001771 scopus 로고    scopus 로고
    • Collagen-targeted MRI contrast agent for molecular imaging of fibrosis
    • Caravan, P. et al. Collagen-targeted MRI contrast agent for molecular imaging of fibrosis. Angew Chem Int Ed Engl 46, 8171-8173 (2007).
    • (2007) Angew Chem Int Ed Engl , vol.46 , pp. 8171-8173
    • Caravan, P.1
  • 33
    • 84865136247 scopus 로고    scopus 로고
    • Molecular MR imaging of liver fibrosis: A feasibility study using rat and mouse models
    • Polasek, M. et al. Molecular MR Imaging of Liver Fibrosis: A Feasibility Study using Rat and Mouse Models. J Hepatol 57, 549-555 (2012).
    • (2012) J Hepatol , vol.57 , pp. 549-555
    • Polasek, M.1
  • 34
    • 65349087970 scopus 로고    scopus 로고
    • Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: Initial feasibility study in a swine model
    • Spuentrup, E. et al. Molecular magnetic resonance imaging of myocardial perfusion with EP-3600, a collagen-specific contrast agent: initial feasibility study in a swine model. Circulation 119, 1768-1775 (2009).
    • (2009) Circulation , vol.119 , pp. 1768-1775
    • Spuentrup, E.1
  • 35
    • 68549122751 scopus 로고    scopus 로고
    • Magnetic resonance molecular imaging of vascular cell adhesion molecule-1 expression in inflammatory lesions using a peptide-vectorized paramagnetic imaging probe
    • Burtea, C. et al. Magnetic resonance molecular imaging of vascular cell adhesion molecule-1 expression in inflammatory lesions using a peptide-vectorized paramagnetic imaging probe. Journal of medicinal chemistry 52, 4725-4742 (2009).
    • (2009) Journal of Medicinal Chemistry , vol.52 , pp. 4725-4742
    • Burtea, C.1
  • 36
    • 77956642978 scopus 로고    scopus 로고
    • MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting
    • De Leon-Rodriguez, L. M. et al. MRI detection of VEGFR2 in vivo using a low molecular weight peptoid-(Gd)8-dendron for targeting. Journal of the American Chemical Society 132, 12829-12831 (2010).
    • (2010) Journal of the American Chemical Society , vol.132 , pp. 12829-12831
    • De Leon-Rodriguez, L.M.1
  • 37
    • 41849094105 scopus 로고    scopus 로고
    • PAMAM dendrimer-based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach
    • Zhu, W., Okollie, B., Bhujwalla, Z. M., Artemov, D. PAMAM dendrimer-based contrast agents for MR imaging of Her-2/neu receptors by a three-step pretargeting approach. Magn Reson Med 59, 679-685 (2008).
    • (2008) Magn Reson Med , vol.59 , pp. 679-685
    • Zhu, W.1    Okollie, B.2    Bhujwalla, Z.M.3    Artemov, D.4
  • 38
    • 0035845635 scopus 로고    scopus 로고
    • Novel MRI contrast agent for molecular imaging of fibrin: Implications for detecting vulnerable plaques
    • Flacke, S. et al. Novel MRI contrast agent for molecular imaging of fibrin: implications for detecting vulnerable plaques. Circulation 104, 1280-1285 (2001).
    • (2001) Circulation , vol.104 , pp. 1280-1285
    • Flacke, S.1
  • 39
    • 73349083082 scopus 로고    scopus 로고
    • Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T1 magnetic resonance imaging contrast agent
    • Cheng, Z., Thorek, D. L., Tsourkas, A. Gadolinium-conjugated dendrimer nanoclusters as a tumor-targeted T1 magnetic resonance imaging contrast agent. Angew Chem Int Ed Engl 49, 346-350 (2010).
    • (2010) Angew Chem Int Ed Engl , vol.49 , pp. 346-350
    • Cheng, Z.1    Thorek, D.L.2    Tsourkas, A.3
  • 40
    • 84859348785 scopus 로고    scopus 로고
    • Molecular and cellular targets of the MRI contrast agent P947 for atherosclerosis imaging
    • Ouimet, T. et al. Molecular and cellular targets of the MRI contrast agent P947 for atherosclerosis imaging. Mol Pharm 9, 850-861 (2012).
    • (2012) Mol Pharm , vol.9 , pp. 850-861
    • Ouimet, T.1
  • 41
    • 34547726181 scopus 로고    scopus 로고
    • A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord
    • Sun, Y. G., Chen, Z. F. A gastrin-releasing peptide receptor mediates the itch sensation in the spinal cord. Nature 448, 700-703 (2007).
    • (2007) Nature , vol.448 , pp. 700-703
    • Sun, Y.G.1    Chen, Z.F.2
  • 43
    • 84888361759 scopus 로고    scopus 로고
    • Influence of different chelators on the radiochemical properties of a 68-Gallium labelled bombesin analogue
    • Asti, M. et al. Influence of different chelators on the radiochemical properties of a 68-Gallium labelled bombesin analogue. Nuclear medicine and biology 41, 24-35 (2014).
    • (2014) Nuclear Medicine and Biology , vol.41 , pp. 24-35
    • Asti, M.1
  • 44
    • 84904801498 scopus 로고    scopus 로고
    • The effect of mini-PEG-based spacer length on binding and pharmacokinetic properties of a 68Ga-labeled NOTA-conjugated antagonistic analog of bombesin
    • Varasteh, Z. et al. The effect of mini-PEG-based spacer length on binding and pharmacokinetic properties of a 68Ga-labeled NOTA-conjugated antagonistic analog of bombesin. Molecules 19, 10455-10472 (2014).
    • (2014) Molecules , vol.19 , pp. 10455-10472
    • Varasteh, Z.1
  • 45
    • 84908009583 scopus 로고    scopus 로고
    • PET imaging of prostate tumors with 18F-Al-NOTA-MATBBN
    • Pan, D. et al. PET imaging of prostate tumors with 18F-Al-NOTA-MATBBN. Contrast media & molecular imaging 9, 342-348 (2014).
    • (2014) Contrast Media & Molecular Imaging , vol.9 , pp. 342-348
    • Pan, D.1
  • 46
    • 84891695913 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of a (18)F-labeled high affinity NOTA conjugated bombesin antagonist as a PET ligand for GRPR-targeted tumor imaging
    • Varasteh, Z. et al. In vitro and in vivo evaluation of a (18)F-labeled high affinity NOTA conjugated bombesin antagonist as a PET ligand for GRPR-targeted tumor imaging. PloS one 8, e81932 (2013).
    • (2013) PloS One , vol.8 , pp. e81932
    • Varasteh, Z.1
  • 47
    • 84888644147 scopus 로고    scopus 로고
    • Multifunctional targeted therapy system based on (99m) Tc/(177) Lu-labeled gold nanoparticles-Tat(49-57)-Lys(3)-bombesin internalized in nuclei of prostate cancer cells
    • Jimenez-Mancilla, N. et al. Multifunctional targeted therapy system based on (99m) Tc/(177) Lu-labeled gold nanoparticles-Tat(49-57)-Lys(3)-bombesin internalized in nuclei of prostate cancer cells. Journal of labelled compounds & radiopharmaceuticals 56, 663-671 (2013).
    • (2013) Journal of Labelled Compounds & Radiopharmaceuticals , vol.56 , pp. 663-671
    • Jimenez-Mancilla, N.1
  • 48
    • 84887358740 scopus 로고    scopus 로고
    • Synthesis and in vitro and in vivo evaluation of hypoxia-enhanced 111In-bombesin conjugates for prostate cancer imaging
    • Zhou, Z. et al. Synthesis and in vitro and in vivo evaluation of hypoxia-enhanced 111In-bombesin conjugates for prostate cancer imaging. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 54, 1605-1612 (2013).
    • (2013) Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine , vol.54 , pp. 1605-1612
    • Zhou, Z.1
  • 49
    • 13244258348 scopus 로고    scopus 로고
    • Efficient relaxivity enhancement in dendritic gadolinium complexes: Effective motional coupling in medium molecular weight conjugates
    • Fulton, D. A. et al. Efficient relaxivity enhancement in dendritic gadolinium complexes: effective motional coupling in medium molecular weight conjugates. Chemical communications, 474-476 (2005).
    • (2005) Chemical Communications , pp. 474-476
    • Fulton, D.A.1
  • 50
    • 33644767065 scopus 로고    scopus 로고
    • Glycoconjugates of gadolinium complexes for MRI applications
    • Fulton, D. A. et al. Glycoconjugates of gadolinium complexes for MRI applications. Chemical communications, 1064-1066 (2006).
    • (2006) Chemical Communications , pp. 1064-1066
    • Fulton, D.A.1
  • 51
    • 0033363494 scopus 로고    scopus 로고
    • Gadolinium(III) chelates as MRI contrast agents: Structure dynamics, and applications
    • Caravan, P., Ellison, J. J., McMurry, T. J., Lauffer, R. B. Gadolinium(III) Chelates as MRI Contrast Agents: Structure, Dynamics, and Applications. Chemical reviews 99, 2293-2352 (1999).
    • (1999) Chemical Reviews , vol.99 , pp. 2293-2352
    • Caravan, P.1    Ellison, J.J.2    McMurry, T.J.3    Lauffer, R.B.4
  • 52
    • 84865529974 scopus 로고    scopus 로고
    • The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members
    • Uehara, H. et al. The molecular basis for high affinity of a universal ligand for human bombesin receptor (BnR) family members. Biochemical pharmacology 84, 936-948 (2012).
    • (2012) Biochemical Pharmacology , vol.84 , pp. 936-948
    • Uehara, H.1
  • 53
    • 0035937737 scopus 로고    scopus 로고
    • Rational design of a peptide agonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3
    • Mantey, S. A. et al. Rational design of a peptide agonist that interacts selectively with the orphan receptor, bombesin receptor subtype 3. The Journal of biological chemistry 276, 9219-9229 (2001).
    • (2001) The Journal of Biological Chemistry , vol.276 , pp. 9219-9229
    • Mantey, S.A.1
  • 54
    • 0026802337 scopus 로고
    • Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides
    • Wang, L. H. et al. Activation of neuromedin B-preferring bombesin receptors on rat glioblastoma C-6 cells increases cellular Ca2+ and phosphoinositides. The Biochemical journal 286 ( Pt 2), 641-648 (1992).
    • (1992) The Biochemical Journal , vol.286 , pp. 641-648
    • Wang, L.H.1
  • 56
    • 67651102575 scopus 로고    scopus 로고
    • Peptide-targeted diagnostics and radiotherapeutics
    • Tweedle, M. F. Peptide-targeted diagnostics and radiotherapeutics. Accounts of chemical research 42, 958-968 (2009).
    • (2009) Accounts of Chemical Research , vol.42 , pp. 958-968
    • Tweedle, M.F.1
  • 57
    • 79953054576 scopus 로고    scopus 로고
    • The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect
    • Fang, J., Nakamura, H., Maeda, H. The EPR effect: Unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect. Advanced drug delivery reviews 63, 136-151 (2011).
    • (2011) Advanced Drug Delivery Reviews , vol.63 , pp. 136-151
    • Fang, J.1    Nakamura, H.2    Maeda, H.3
  • 58
    • 33644772618 scopus 로고    scopus 로고
    • Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers
    • Dreher, M. R. et al. Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers. Journal of the National Cancer Institute 98, 335-344 (2006).
    • (2006) Journal of the National Cancer Institute , vol.98 , pp. 335-344
    • Dreher, M.R.1
  • 59
    • 84930226634 scopus 로고    scopus 로고
    • Protein MRI contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging
    • Xue, S. et al. Protein MRI contrast agent with unprecedented metal selectivity and sensitivity for liver cancer imaging. Proceedings of the National Academy of Sciences 112, 6607-6612 (2015).
    • (2015) Proceedings of the National Academy of Sciences , vol.112 , pp. 6607-6612
    • Xue, S.1
  • 60
    • 33847693865 scopus 로고    scopus 로고
    • Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner
    • Zhang, C. et al. Specific targeting of tumor angiogenesis by RGD-conjugated ultrasmall superparamagnetic iron oxide particles using a clinical 1.5-T magnetic resonance scanner. Cancer research 67, 1555-1562 (2007).
    • (2007) Cancer Research , vol.67 , pp. 1555-1562
    • Zhang, C.1
  • 61
    • 84880674739 scopus 로고    scopus 로고
    • Molecular MR imaging of neovascular progression in the Vx2 tumor with alphavbeta3-targeted paramagnetic nanoparticles
    • Schmieder, A. H. et al. Molecular MR imaging of neovascular progression in the Vx2 tumor with alphavbeta3-targeted paramagnetic nanoparticles. Radiology 268, 470-480 (2013).
    • (2013) Radiology , vol.268 , pp. 470-480
    • Schmieder, A.H.1
  • 63
    • 0032697682 scopus 로고    scopus 로고
    • Near-infrared optical imaging of protease activity for tumor detection
    • Mahmood, U., Tung, C. H., Bogdanov, A. Jr., Weissleder, R. Near-infrared optical imaging of protease activity for tumor detection. Radiology 213, 866-870 (1999).
    • (1999) Radiology , vol.213 , pp. 866-870
    • Mahmood, U.1    Tung, C.H.2    Bogdanov, A.3    Weissleder, R.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.