Synthesis, in vitro receptor binding, and in vivo evaluation of fluorescein and carbocyanine peptide-based optical contrast agents

Journal of Medicinal Chemistry

Volumn 45, Issue 10, 2002, Pages 2003-2015

  Achilefu, Samuel ^a   Jimenez, Hermo N ^b   Dorshow, Richard B ^b   Bugaj, Joseph E ^b   Webb, Elizabeth G ^b   Wilhelm, R Randy ^b   Rajagopalan, Raghavan ^b   Johler, Jill ^b   Erion, Jack L ^b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MALLINCKRODT PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BOMBESIN; CARBOCYANINE; CONTRAST MEDIUM; FLUORESCEIN; SOMATOSTATIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIAGNOSTIC VALUE; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE OVEREXPRESSION; IMAGE ENHANCEMENT; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; RAT; TUMOR CELL LINE; TUMOR LOCALIZATION;

ANIMALS; BOMBESIN; CARBOCYANINES; CHELATING AGENTS; CONTRAST MEDIA; FLUORESCEINS; LIGANDS; NEOPLASM TRANSPLANTATION; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; RADIOLIGAND ASSAY; RATS; RECEPTORS, BOMBESIN; RECEPTORS, SOMATOSTATIN; SOMATOSTATIN; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; TUMOR CELLS, CULTURED;

EID: 0037046519     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010519l     Document Type: Article

References (48)

1. Noninvasive functional optical spectroscopy of human breast tissue
2. Developments toward diagnostic breast cancer imaging using near-infrared optical measurements and fluorescent contrast agents
3. Pilot comparison of light-based optical tomography versus ultrasound for real-time imaging of neonatal intraventricular hemorrhage
4. Simultaneous time of-flight adjusted (TOFA) near-infrared spectroscopy and magnetic resonance imaging of immature rabbit hypoxic-ischemic encephalopathy (HIE)
5. In vivo fluorescence spectroscopy and imaging for oncological applications
6. Chance diffuse optical tomography of breast after indocyanine green enhancement
7. Fluorescence imaging during photodynamic therapy of experimental tumors in mice sensitized with disulfonated aluminum phthalocyanine
8. Sources of absorption and scattering contrast for near-infrared optical mammography
9. Three-dimensional time-resolved optical tomography of a conical breast phantom
10. Optimization of optode arrangements for diffuse optical tomography: A singular-value analysis
11. A diffusion theory model of spatially resolved fluorescence from depth-dependent fluorophore concentrations
12. Three-dimensional simulation of near-infrared diffusion in tissue: Boundary condition and geometry analysis for finite-element image reconstruction
13. Spectroscopic diffuse optical tomography for the quantitative assessment of hemoglobin concentration and oxygen saturation in breast tissue
14. Continuous-wave diffusion imaging
15. Fluorescence-enhanced absorption imaging using frequency-domain photon migration: Tolerance to measurement error
16. Tumor receptor imaging: Proceedings of the national cancer institute workshop, review of current work, and prospective for further investigations
17. Interstitial transport of rabbit and sheep antibodies in normal and neoplas tic tissues
18. Antibody fluorescein conjugates for photoimmunodiagnosis of human colon-carcinoma in nude-mice
19. Carcinoembryonic antigen expression, antibody localisation and immunophotodetection of human colon cancer liver metastases in nude mice: A model for radioimmunotherapy
20. Antibody-indocyanin conjugates for immunophotodetection of human squamous-cell carcinoma in nude-mice
21. Cyanine fluorochrome-labeled antibodies in vivo: Assessment of tumor imaging using Cy3, Cy5, Cy5.5, and Cy7
22. Tumor detection and visualization using cyanine fluorochrome-labeled antibodies
23. Tumor labeling in-vivo using cyanine-conjugated monoclonal-antibodies
24. Macromolecular contrast agents for optical imaging of tumors: Comparison of indotricarbocyanine-labeled human serum albumin and transferrin
25. In vivo molecular target assessment of matrix metalloproteinase inhibition
26. Preparation of a cathepsin D sensitive near-infrared fluorescence probe for imaging
27. Novel receptor-targeted fluorescent contrast agents for in vivo tumor imaging
28. Receptor-targeted optical imaging of tumors with near-infrared fluorescent ligands
29. Novel fluorescent contrast agents for optical imaging of in vivo tumors based on a receptor-targeted dye-peptide conjugate platform
30. Analogues of somatostatin selectively label distinct subtypes of somatostatin receptors in rat-brain
31. Somatostatin receptor sstl-sst5 expression in normal and neoplastic human tissues using receptor autoradiography with subtype-selective ligands
32. Imaging tumors with peptide-based radioligands
33. Nuclear localization of In-111 after intravenous injection of [In-111-DTPA-D-Phe(1)]-octreotide in patients with neuroendocrine tumors
34. In vitro and in vivo evaluation of Cu-64-TETA-Tyr(3)-octreotate. A new somatostatin analogue with improved target tissue uptake
35. Radiometalated receptor-avid peptide conjugates for specific in vivo targeting of cancer cells
36. Clinical imaging of cancer metastasis
37. Bedside imaging of intracranial hemorrhage in the neonate using light: Comparison with ultrasound, computed tomography, and magnetic resonance imaging
38. Optical imaging of anatomical maps derived from magnetic resonance images using time-independent optical sources
39. Generally applicable, convenient solid-phase synthesis and receptor affinities of octreotide analogues
40. A new method for the synthesis of tri-tert-butyl diethylenetriaminepentaacetic acid and its derivatives
41. Structural characteristics of fluorophores that form intramolecular H-type dimers in a protease substrate
42. Applications of molecular mechanics to metal-based imaging agents
43. [Lu-177-DOTA(0), Tyr(3)]octreotate for somatostatin receptor-targeted radionuclide therapy
44. Tc-99m-labeling and in vivo studies of a bombesin analogue with a novel water-soluble dithiadiphosphine-based bifunctional chelating agent
45. Probing physiology and molecular function using optical imaging: Applications to breast cancer
46. In vivo and in vitro expression of somatostatin receptors in two human thymomas with similar clinical presentation and different histological features
47. The somatostatin receptor-targeted radiotherapeutic [Y-90-DOTA-DPhe(1), Tyr(3)]octreotide (Y-90-SMT 487) eradicates experimental rat pancreatic CA 20948 tumours