Molecular and cellular targets of the MRI contrast agent P947 for atherosclerosis imaging

Molecular Pharmaceutics

Volumn 9, Issue 4, 2012, Pages 850-861

  Ouimet, Tanja ^a   Lancelot, Eric ^b   Hyafil, Fabien ^c   Rienzo, Mario ^d   Deux, François ^d   Lemaître, Marjorie ^b   Duquesnoy, Sophie ^a   Garot, Jérome ^d   Roques, Bernard P ^a   Michel, Jean Baptiste ^e   Corot, Claire ^b   Ballet, Sébastien ^b  

^a Pharmaleads   (France)

^b Laboratoire Guerbet   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d HENRI MONDOR HOSPITAL   (France)

^e BICHAT HOSPITAL   (France)

Author keywords

atherosclerosis; atherosclerotic rabbit model; macrophage; metalloproteinases; molecular imaging; MRI; P947

Indexed keywords

DIPEPTIDYL CARBOXYPEPTIDASE; ENDOTHELIN CONVERTING ENZYME; GADOTERIC ACID; GLUTAMYL AMINOPEPTIDASE; MATRIX METALLOPROTEINASE; MEMBRANE METALLOENDOPEPTIDASE; MICROSOMAL AMINOPEPTIDASE; NUCLEAR MAGNETIC RESONANCE IMAGING AGENT; P 947; UNCLASSIFIED DRUG;

AFFINITY LABELING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROTIC PLAQUE; BINDING AFFINITY; CAROTID ATHEROSCLEROSIS; ENZYME ASSAY; ENZYME BINDING; EX VIVO STUDY; EXPERIMENTAL RABBIT; FLUOROMETRY; FOAM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LEUKEMIA CELL LINE; LYMPHOCYTE; MACROPHAGE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SIGNAL NOISE RATIO; T LYMPHOCYTE; UMBILICAL VEIN ENDOTHELIAL CELL;

AMINOPEPTIDASES; ANIMALS; ASPARTIC ACID ENDOPEPTIDASES; ATHEROSCLEROSIS; CONTRAST MEDIA; FLUOROMETRY; HUMANS; MAGNETIC RESONANCE IMAGING; METALLOENDOPEPTIDASES; NEPRILYSIN; PEPTIDYL-DIPEPTIDASE A; PLAQUE, ATHEROSCLEROTIC; RABBITS;

EID: 84859348785     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp2003863     Document Type: Article

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