Molecular docking study, synthesis and biological evaluation of Mannich bases as Hsp90 inhibitors

International Journal of Biological Macromolecules

Volumn 80, Issue , 2015, Pages 253-259

  Gupta, Sayan Dutta ^a,c   Bommaka, Manish Kumar ^a   Mazaira, Gisela I ^d   Galigniana, Mario D ^d,e   Subrahmanyam, Chavali Venkata Satya ^a   Gowrishankar, Naryanasamy Lachmana ^b   Raghavendra, Nulgumnalli Manjunathaiah ^a  

^a Osmania University   (India)

^b Swami Viveka Nanda Institute of Pharmaceutical Sciences   (India)

^c JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e Institute of Experimental Biology and Medicine CONICET ^*  (Argentina)

Author keywords

Docking; Hsp90; Mannich base

Indexed keywords

1 [3 (2,4 DIHYDROXYPHENYL) 3 OXOPROPYL]PIPERIDIN 1 IUM CHLORIDE; 1 [3 (5 CHLORO 2,4 DIHYDROXYPHENYL) 3 OXOPROPYL]PIPERIDIN 1 IUM CHLORIDE; 2,4 DIHYDROXYACETOPHENONE; 3 (2,4 DIHYDROXYPHENYL) N,N DIMETHYL 3 OXOPROPAN 1 AMINIUM CHLORIDE; 3 (5 CHLORO 2,4 DIHYDROXYPHENYL) N,N DIMETHYL 3 OXOPROPAN 1 AMINIUM CHLORIDE; 4 [3 (2,4 DIHYDROXYPHENYL) 3 OXOPROPYL]MORPHOLIN 4 IUM CHLORIDE; 4 [3 (5 CHLORO 2,4 DIHYDROXYPHENYL) 3 OXOPROPYL]MORPHOLIN 4 IUM CHLORIDE; 5 CHLORO 2,4 DIHYDROXYACETOPHENONE; ACETOPHENONE DERIVATIVE; ADENOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; MALACHITE GREEN; MANNICH BASE; UNCLASSIFIED DRUG; WATER; 2,4,6-TRIHYDROXYACETOPHENONE; ANTINEOPLASTIC AGENT;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; COLORIMETRY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DESIGN PROGRAM; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MOLECULAR DOCKING; MTT ASSAY; PANCREAS CARCINOMA; PREDICTION; PROTON NUCLEAR MAGNETIC RESONANCE; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; METABOLISM; PROTEIN CONFORMATION; SYNTHESIS; TUMOR CELL LINE;

ACETOPHENONES; ADENOSINE TRIPHOSPHATASES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG DESIGN; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MANNICH BASES; MOLECULAR DOCKING SIMULATION; PROTEIN CONFORMATION; WATER;

EID: 84947296012     PISSN: 01418130     EISSN: 18790003     Source Type: Journal    
DOI: 10.1016/j.ijbiomac.2015.06.039     Document Type: Article

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