Effect of acetophenone derived Mannich bases on cellular glutathione level in Jurkat cells. A possible mechanism of action

Arzneimittel-Forschung/Drug Research

Volumn 51, Issue 8, 2001, Pages 679-682

  Gul, M ^a   Gul, H I ^a   Vepsalainen, J ^a   Erciyas, E ^a   Hanninen, O ^a  

^a ATATÜRK UNIVERSITY   (Turkey)

Author keywords

Acetophenone derivatives, effects on cellular glutathione levels, in vitro studies; Glutathione; Mannich bases, cytotoxic activity, mechanism of action

Indexed keywords

ACETOPHENONE; GLUTATHIONE; MANNICH BASE;

ALKYLATION; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; STRUCTURE ANALYSIS;

EID: 0034887801     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1300100     Document Type: Article

References (18)

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2. Antimicrobial evaluation of some styryl ketone derivatives and related thiol adducts
3. Synthesis of Mannich bases of 5-hydroxynapthalene-1,8-carbolactone as potential antifungal or antitumor agents
4. Antifungal activity of some mono, bis and quaternary Mannich bases derived from acetophenone
5. Cytotoxic activities of Mannich bases of chalcones and related compounds
6. Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells
7. Evaluation of cytotoxicity of some Mannich bases of various aryl and arylidene ketones and their corresponding arylhydrazones
8. Beta-amino-ketones as anti-infective agents
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14. Activity of some Mannich bases of conjugated styryl ketones against Candida albicans
15. bis-Mannich bases of styryl ketones as antileukemic agents
16. The effect of inhibition of glutathione S-transferase P on the growth of the Jurkat human T cell line
17. Glutathione S-conjugate transport by cultured human cells