2,4-dihydroxy benzaldehyde derived Schiff bases as small molecule Hsp90 inhibitors: Rational identification of a new anticancer lead

Bioorganic Chemistry

Volumn 59, Issue , 2015, Pages 97-105

  Dutta Gupta, Sayan ^a,b   Revathi, B ^a   Mazaira, Gisela I ^d   Galigniana, Mario D ^d,e   Subrahmanyam, C V S ^a   Gowrishankar, N L ^c   Raghavendra, N M ^a  

^a Osmania University   (India)

^b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^c Swami Vivekananda Institute of Pharmaceutical Sciences   (India)

^d UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^e Institute of Experimental Biology and Medicine CONICET   (Argentina)

Author keywords

Anticancer; Docking; Hsp90; Malachite green; MTT

Indexed keywords

4 (HYDRAZONOMETHYL)BENZENE 1,3 DIOL; 4 [(2 PHENYLHYDRAZONO)METHYL]BENZENE 1,3 DIOL; 4 [(2,4 DIHYDROXYBENZYLIDENE)AMINO] 3 HYDROXYNAPHTHALENE 1 SULFONIC ACID; 4 [(BENZO[D]THIAZOL 2 YLIMINO)METHYL]BENZENE 1,3 DIOL; 4 [(BENZYLIMINO)METHYL]BENZENE 1,3 DIOL; 4 [(BUTYLIMINO)METHYL]BENZENE 1,3 DIOL; 4 [(NAPHTHALEN 1 YLIMINO)METHYL]BENZENE 1,3 DIOL; 4 [(PHENYLIMINO)METHYL]BENZENE 1,3 DIOL; 4 [(THIAZOL 2 YLIMINO)METHYL]BENZENE 1,3 DIOL; 4 [[(2 HYDROXYPHENYL)IMINO]METHYL]BENZENE 1,3 DIOL; 4 [[(4 FLUOROPHENYL)IMINO]METHYL]BENZENE 1,3 DIOL; 4 [[2 (2,4 DINITROPHENYL)HYDRAZONO]METHYL]BENZENE 1,3 DIOL; 4 [[[4 (1H BENZO[D]IMIDAZOL 2 YL)PHENYL]IMINO]METHYL]BENZENE 1,3 DIOL; BENZALDEHYDE DERIVATIVE; CYTOTOXIC AGENT; HEAT SHOCK PROTEIN 90 INHIBITOR; SCHIFF BASE; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BENZALDEHYDE; HEAT SHOCK PROTEIN 90;

ABSORPTION; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG IDENTIFICATION; DRUG PENETRATION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HYDROGEN BOND; IC50; IN VITRO STUDY; MALE; MOLECULAR DOCKING; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROSTATE CANCER; PROSTATE CANCER CELL LINE; PROTON NUCLEAR MAGNETIC RESONANCE; SOLUBILIZATION; SPECTROSCOPY; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PATHOLOGY; PROSTATE; PROSTATIC NEOPLASMS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZALDEHYDES; CELL LINE, TUMOR; DRUG DESIGN; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MALE; MODELS, MOLECULAR; PROSTATE; PROSTATIC NEOPLASMS; SCHIFF BASES;

EID: 84923673347     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2015.02.003     Document Type: Article

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