Evaluation of the cytotoxicity of some mono-Mannich bases and their corresponding azine derivatives against androgen-independent prostate cancer cells

Arzneimittel-Forschung/Drug Research

Volumn 56, Issue 12, 2006, Pages 850-855

  Gul, Halise Inci ^a   Das, Umashankar ^b   Pandit, Bulbul ^c   Li, Pui Kai ^c  

^a ATATÜRK UNIVERSITY   (Turkey)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

Acetophenone Mannich bases, effects on PC 3 cell line; Anticancer agents; Azine Mannich bases, effects on PC 3 cell line; Rostate cancer cells

Indexed keywords

1 ARYL 3 AMINO 1 PROPANONE HYDROCHLORIDE DERIVATIVE; ACETOPHENONE DERIVATIVE; ALKYLATING AGENT; ANDROGEN; FLUOROURACIL; MANNICH BASE; N,N' BIS(3 AMINO 1 ARYLPROPYLIDENE)HYDRAZINE DIHYDROCHLORIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; PKA; PROSTATE CANCER; SUBSTITUTION REACTION;

EID: 33845915669     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296797     Document Type: Article

References (34)

1. Erciyas, E., Erkaleli, H. I., Cosar, G., Antimicrobial Evaluation of Some Styryl Ketone Derivatives and Related Thiol Adducts. J. Pharm. Sc. 83, 545 (1994)
2. Gul, H. I., Ojanen, T., Vepsalainen, J. et al., Antifungal Activity of Some Mono, Bis and Quaternary Mannich Bases Derived from Acetophenone. Arzneim.-Forsch./Drug Res. 51, 72 (2001)
3. Gul, H. I., Denizci, A. A., Erciyas, E., Antimicrobial Evaluation of Some Mannich Bases of Acetophenones and Their Representative Quaternary Derivatives. Arzneim.-Forsch./Drug Res. 52, 773 (2002)
4. Gul, H.I., Ojanen, T., Hanninen, O., Antifungal Evaluation of Some Bis Mannich Bases Derived from Acetophenone and Their Corresponding Piperidinols and Stability Studies. Biol. Pharm. Bull. 25, 1307 (2002)
5. Manavathu, E. K., Vashishtha, S. C., Alangaden, G. J. et al., In Vitro Antifungal Activity of Some Mannich Bases of Conjugated Styryl Ketones. Can. J. Microbiol. 44, 74 (1998)
6. Gul, H. I., Sahin, F., Gul, M. et al., Evaluation of Antimicrobial Activities of Several Mannich Bases and Their Derivatives. Arch Pharm (Weinheim) 338, 335 (2005)
7. Gul, H. I., Gul, M., Erciyas, E., Syntheses and Stability Studies of Some Mannich Bases of Acetophenones and Evaluation of Their Cytotoxicity against Jurkat Cells. Arzneim.-Forsch./Drug Res. 52, 628 (2002)
8. Gul, H. I., Vepsalainen, J., Gul, M. et al., Cytotoxic Activities of Mono and Bis Mannich Bases Derived from Acetophenone against Renca and Jurkat Cells. Pharm. Acta Helv. 74, 393 (2000)
9. Gul, H. I., Gul, M., Härminen, O., Cytotoxic Activities of Some Mono and Bis Mannich Bases Derived from Acetophenone in Brine Shrimp Bioassay. 52, 840 (2002)
10. Gul, H. I., Gul, M., Erciyas, E., Toxicity of Some Bis Mannich Bases and Corresponding Piperidinols in the Brine Shrimp (Artemia Salina) Bioassay. J. Appl. Toxicol. 23, 53 (2003)
11. Gul, H. I., Gul, M., Vepsalainen, J. et al., Cytotoxicity of Some Azines of Acetophenone Derived Mono-Mannich Bases against Jurkat Cells. Biol. Pharm. Bull. 26, 631 (2003)
12. Dimmock, J. R., Kumar, P., Anticancer and Cytotoxic Properties of Mannich Bases. Curr. Med. Chem. 4, 1 (1997)
13. Atwal, M. S., Bauer, I., Dixit, S. N. et al., Analgetics. II. Relationship between Structure and Activity of Some Beta-Aminoketones. J. Med. Chem. 12, 994 (1969)
14. Chen, H., Ji, Z., Wong, L. K. et al., Synthesis, Antiinflammatory, and Cytotoxic Activities of 2-Alkyl and 2-Benzyl-2-Dimethylaminomethyl-5-(E)- Arylidene Cyclopentanone Hydrochlorides. Pharm. Res. 13, 1482 (1996)
15. Palaska, E., Unlu, S., Ozkanli, F. et al., 3-Substituted Piperazinomethyl Benzoxazolinones. Analgesic and Anti-Inflammatory Compounds Inhibiting Prostaglandin E2. Arzneim.-Forsch./Drug Res. 45, 693 (1995)
16. Suleyman, H., Gul, H. I., Asoglu, M. Antiinflammatory Activity of 3-Benzoyl-1-Methyl-4-Phenyl-4-Piperidinol Hydrochloride. Pharmacol. Res. 47, 471 (2003)
17. Koechel, D. A., Rankin, G. O., Diuretic Activity of Mannich Base Derivatives of Ethacrynic Acid and Certain Ethacrynic Acid Analogues. J. Med. Chem. 21, 764 (1978)
18. Lee, C. M., Plattner, J. J., Ours, C. W. et al., [(Aminomethyl)Aryloxy] Acetic Acid Esters. A New Class of High-Ceiling Diuretics. 1. Effects of Nitrogen and Aromatic Nuclear Substitution. J. Med. Chem. 27, 1579 (1984)
19. Borenstein, M. R., Doukas, P. H., Anticonvulsant Activity of Indanylspirosuccinimide Mannich Bases. J. Pharm. Sci. 76, 300 (1987)
20. Dimmock, J. R., Jonnalagadda, S. S., Phillips, O. A. et al., Anticonvulsant Properties of Some Mannich Bases of Conjugated Arylidene Ketones. J. Pharm. Sci. 81, 436 (1992)
21. Gul, H. I., Calis, U., Vepsalainen, J., Synthesis and Evaluation of Anticonvulsant Activities of Some Bis-Mannich Bases and Corresponding Piperidinols. Arzneim.-Forsch./Drug Res. 52, 863 (2002)
22. Gursoy, A., Karali, N., Buyuktimkin, S. et al., Some 3-Hydrazono-2- Indolinones and N-Mannich Bases as Potential Anticonvulsants. Farmaco. 51, 437 (1996)
23. Gul. H. I., Calis, U., Vepsalainen, J., Synthesis of Some Mono-Mannich Bases and Corresponding Azine Derivatives and Evaluation of Their Anticonvulsant Activity. Arzneim.-Forsch./Drug Res. 54, 359 (2004)
24. Gordon, P. N., Johnston, J. D., English, A. R., Beta-Aminoketones as Anti-Infective Agents, in: G. L. Hobby (ed.), Antimicrobial Agents and Chemotherapy, pp 165, American Society for Microbiology, Bethesda, MD (1965)
25. Nyathi, C. B., Gupta, V. S., Dimmock, J. R., Evaluation of 1-(3,4-Dichlorophenyl)-4-Dimethylaminomethyl-1-Nonen-3-One Hydrochloride Effect on Nucleic Acid and Protein Syntheses Using Murine Leukemia L-1210 Cells. J. Pharm. Sci. 68, 1383 (1979)
26. Schoenenberger, H., Bastug, T., Bindl, L. et al., Action Mechanism of Antimicrobial Beta-Amino Ketones. Pharm. Acta Helv. 44, 691 (1969)
27. Dimmock, J. R., Taylor, W. G., Evaluation of Nuclear-Substituted Styryl Ketones and Related Compounds for Antitumor and Cytotoxic Properties. J. Pharm. Sci. 64, 41 (1975)
28. Gul, M., Gul, H. I., Vepsalainen, J. et al., Effect of Acetophenone Derived Mannich Bases on Cellular Glutathione Level in Jurkat Cells: A Possible Mechanism of Action. Arzneim.-Forsch./Drug Res. 51, 679 (2001)
29. Gul, M., Gul, H. I., Hanninen, O., Effects of Mannich Bases on Cellular Glutathione and Related Enzymes of Jurkat Cells in Culture Conditions. Toxicol. in Vitro 16, 107 (2002)
30. Gul, M., Atalay, M., Gul, H. I. et al., The Effects of Some Mannich Bases on Heat Shock Proteins Hsc70 and Grp75, and Thioredoxin and Glutaredoxin Levels in Jurkat Cells. Toxicol. in Vitro 19, 573 (2005)
31. Gul, M., Kutay, F. Z., Temocin, S. et al., Cellular and Clinical Implications of Glutathione. Indian J. Exp. Biol. 38, 625 (2000)
32. Dimmock, J. R., Erciyas, E., Kirkpatrick, D. L. et al., Evaluation of Some Azines of Aminomethylacetophenones and Related Quaternary Ammonium Compounds Versus the Emt6 Tumour. Pharmazie 43, 614 (1988)
33. Cory, A. H., Owen, T. C., Barltrop, J. A. et al., Use of an Aqueous Soluble Tetrazolium/Formazan Assay for Cell Growth Assays in Culture. Cancer Communications 3, 207 (1991)
34. Dimmock, J. R., Jonnalagadda, S. S., Leek, D. M. et al., Evaluation of Mannich Bases of Styryl Ketones and Related Hydrazones for Activity against P388 Leukemia. Neoplasma 35, 715 (1988)