Native Coronary Artery and Bypass Graft Atherosclerosis

PanVascular Medicine, Second Edition

Volumn , Issue , 2015, Pages 273-301

  Yahagi, Kazuyuki ^a   Otsuka, Fumiyuki ^a   Sakakura, Kenichi ^a   Joner, Michael ^a   Virmani, Renu ^a  

^a CVPATH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84947241728     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-37078-6_15     Document Type: Chapter

References (136)

1. Accad M, Smith SJ, Newland DL (2000) Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA: cholesterol acyltransferase 1. J Clin Invest 105: 711–719
2. Aikawa M, Rabkin E, Okada Y (1998) Lipid lowering by diet reduces matrix metalloproteinase activity and increases collagen content of rabbit atheroma: a potential mechanism of lesion stabilization. Circulation 97: 2433–2444
3. Ait-Oufella H, Kinugawa K, Zoll J (2007) Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation 115: 2168–2177
4. Ambrose JA, Winters SL, Stern A (1985) Angiographic morphology and the pathogenesis of unstable angina pectoris. J Am Coll Cardiol 5: 609–616
5. Aprahamian T, Rifkin I, Bonegio R (2004) Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J Exp Med 199: 1121–1131
6. Arbustini E (2007) Total erythrocyte membrane cholesterol: an innocent new marker or an active player in acute coronary syndromes? J Am Coll Cardiol 49: 2090–2092
7. Arbustini E, Morbini P, D'Armini AM (2002) Plaque composition in plexogenic and thromboembolic pulmonary hypertension: the critical role of thrombotic material in pultaceous core formation. Heart (British Cardiac Society) 88: 177–182
8. Atkinson JB, Forman MB, Vaughn WK, Robinowitz M, McAllister HA, Virmani R (1985) Morphologic changes in long-term saphenous vein bypass grafts. Chest 88: 341–348
9. Barner HB (2002) Remodeling of arterial conduits in coronary grafting. Ann Thorac Surg 73: 1341–1345
10. Bashour TT, Hanna ES, Mason DT (1986) Myocardial revascularization with internal mammary artery bypass: an emerging treatment of choice. Am Heart J 111: 143–151
11. Bennett MR, Evan GI, Schwartz SM (1995) Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest 95: 2266–2274
12. Boisvert WA, Rose DM, Boullier A (2006) Leukocyte transglutaminase 2 expression limits atherosclerotic lesion size. Arterioscler Thromb Vasc Biol 26: 563–569
13. Bourassa MG, Fisher LD, Campeau L, Gillespie MJ, McConney M, Lesperance J (1985) Long-term fate of bypass grafts: the Coronary Artery Surgery Study (CASS) and Montreal Heart Institute experiences. Circulation 72: V71–V78
14. Boyle JJ, Harrington HA, Piper E (2009) Coronary intraplaque hemorrhage evokes a novel atheroprotective macrophage phenotype. Am J Pathol 174: 1097–1108
15. Budoff MJ, Gul KM (2008) Expert review on coronary calcium. Vasc Health Risk Manag 4: 315–324
16. Burfeind WR Jr, Glower DD, Wechsler AS (2004) Single versus multiple internal mammary artery grafting for coronary artery bypass: 15-year follow-up of a clinical practice trial. Circulation 110: II27–II35
17. Burke AP, Farb A, Malcom GT, Liang YH, Smialek J, Virmani R (1997) Coronary risk factors and plaque morphology in men with coronary disease who died suddenly. N Engl J Med 336: 1276–1282
18. Burke AP, Farb A, Malcom GT, Liang Y, Smialek J, Virmani R (1998) Effect of risk factors on the mechanism of acute thrombosis and sudden coronary death in women. Circulation 97: 2110–2116
19. Burke AP, Taylor A, Farb A, Malcom GT, Virmani R (2000) Coronary calcification: insights from sudden coronary death victims. Z Kardiol 89(Suppl 2): 49–53
20. Burke AP, Farb A, Malcom G, Virmani R (2001a) Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis. Am Heart J 141: S58–S62
21. Burke AP, Weber DK, Kolodgie FD, Farb A, Taylor AJ, Virmani R (2001b) Pathophysiology of calcium deposition in coronary arteries. Herz 26: 239–244
22. Burke AP, Kolodgie FD, Farb A (2001c) Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation 103: 934–940
23. Burke AP, Virmani R, Galis Z, Haudenschild CC, Muller JE (2003) 34th Bethesda Conference: task force #2–What is the pathologic basis for new atherosclerosis imaging techniques? J Am Coll Cardiol 41: 1874–1886
24. Burke AP, Kolodgie FD, Farb A, Virmani R (2007) Pathogenesis and significance of calcification in coronary atherosclerosis. In: Virmani R, Narula J, Leon MB, Willerson JT (eds) The vulnerable atherosclerotic plaque: strategies for diagnosis and management, 1st edn. Wiley, Malden, Massachusetts, USA, pp 77–94
25. Butany JW, David TE, Ojha M (1998) Histological and morphometric analyses of early and late aortocoronary vein grafts and distal anastomoses. Can J Cardiol 14: 671–677
26. Cameron A, Davis KB, Green G, Schaff HV (1996) Coronary bypass surgery with internal-thoracic-artery grafts–effects on survival over a 15-year period. N Engl J Med 334: 216–219
27. Campeau L, Enjalbert M, Lesperance J (1984) The relation of risk factors to the development of atherosclerosis in saphenous-vein bypass grafts and the progression of disease in the native circulation. A study 10 years after aortocoronary bypass surgery. N Engl J Med 311: 1329–1332
28. Campeau L, Knatterud G, Domanski D (1997) The effect of aggressive lowering of low-density lipoprotein cholesterol levels and low-dose anticoagulation on obstructive changes in saphenous-vein coronary-artery bypass grafts. The post coronary artery bypass graft trial investigators. N Engl J Med 336: 153–162
29. Canham PB, Finlay HM, Boughner DR (1997) Contrasting structure of the saphenous vein and internal mammary artery used as coronary bypass vessels. Cardiovasc Res 34: 557–567
30. Carmeliet P (2005) Angiogenesis in life, disease and medicine. Nature 438: 932–936
31. Chang MK, Binder CJ, Miller YI (2004) Apoptotic cells with oxidation-specific epitopes are immunogenic and proinflammatory. J Exp Med 200: 1359–1370
32. Clarke JA (1964) An X-ray microscopic study of the vasa vasorum of normal human coronary arteries. J Anat 98: 539–543
33. Damgaard S, Steinbruchel DA, Kjaergard HK (2005) An update on internal mammary artery grafting for coronary artery disease. Curr Opin Cardiol 20: 521–524
34. Darbonne WC, Rice GC, Mohler MA (1991) Red blood cells are a sink for interleukin 8, a leukocyte chemotaxin. J Clin Invest 88: 1362–1369
35. Davies MJ (1995) Stability and instability: two faces of coronary atherosclerosis. The Paul Dudley White Lecture 1995. Circulation 94: 2013–2020
36. Davies MJ, Thomas A (1984) Thrombosis and acute coronary-artery lesions in sudden cardiac ischemic death. N Engl J Med 310: 1137–1140
37. Davis GE (1992) The Mac-1 and p150,95 beta 2 integrins bind denatured proteins to mediate leukocyte cellsubstrate adhesion. Exp Cell Res 200: 242–252
38. Dove DE, Su YR, Zhang W (2005) ACAT1 deficiency disrupts cholesterol efflux and alters cellular morphology in macrophages. Arterioscler Thromb Vasc Biol 25: 128–134
39. Falk E, Shah PK, Fuster V (1995) Coronary plaque disruption. Circulation 92: 657–671
40. Falk E, Nakano M, Bentzon JF, Finn AV, Virmani R (2013) Update on acute coronary syndromes: the pathologists’ view. Eur Heart J 34: 719–728
41. Fan J, Watanabe T (2003) Inflammatory reactions in the pathogenesis of atherosclerosis. J Atheroscler Thromb 10: 63–71
42. Farb A, Burke AP, Tang AL (1996) Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation 93: 1354–1363
43. Felton CV, Crook D, Davies MJ, Oliver MF (1997) Relation of plaque lipid composition and morphology to the stability of human aortic plaques. Arterioscler Thromb Vasc Biol 17: 1337–1345
44. Feng B, Yao PM, Li Y (2003) The endoplasmic reticulum is the site of cholesterol-induced cytotoxicity in macrophages. Nat Cell Biol 5: 781–792
45. Ferrante G, Nakano M, Prati F (2010) High levels of systemic myeloperoxidase are associated with coronary plaque erosion in patients with acute coronary syndromes: a clinicopathological study. Circulation 122: 2505–2513
46. Foglieni C, Maisano F, Dreas L (2008) Mild inflammatory activation of mammary arteries in patients with acute coronary syndromes. Am J Physiol Heart Circ Physiol 294: H2831–H2837
47. Galili O, Herrmann J, Woodrum J, Sattler KJ, Lerman LO, Lerman A (2004) Adventitial vasa vasorum heterogeneity among different vascular beds. J Vasc Surg 40: 529–535
48. Galili O, Sattler KJ, Herrmann J (2005) Experimental hypercholesterolemia differentially affects adventitial vasa vasorum and vessel structure of the left internal thoracic and coronary arteries. J Thorac Cardiovasc Surg 129: 767–772
49. Gijsen FJ, Wentzel JJ, Thury A (2008) Strain distribution over plaques in human coronary arteries relates to shear stress. Am J Physiol Heart Circ Physiol 295: H1608–H1614
50. Glaser R, Selzer F, Faxon DP (2005) Clinical progression of incidental, asymptomatic lesions discovered during culprit vessel coronary intervention. Circulation 111: 143–149
51. Goldman S, Zadina K, Moritz T (2004) Long-term patency of saphenous vein and left internal mammary artery grafts after coronary artery bypass surgery: results from a Department of VeteransAffairs Cooperative Study. J Am Coll Cardiol 44: 2149–2156
52. Graversen JH, Madsen M, Moestrup SK (2002) CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma. Int J Biochem Cell Biol 34: 309–314
53. Guyton JR (2001) Phospholipid hydrolytic enzymes in a 'cesspool' of arterial intimal lipoproteins: a mechanism for atherogenic lipid accumulation. Arterioscler Thromb Vasc Biol 21: 884–886
54. Heistad DD, Marcus ML, Larsen GE, Armstrong ML (1981) Role of vasa vasorum in nourishment of the aortic wall. Am J Physiol 240: H781–H787
55. Hildebrandt HA, Gossl M, Mannheim D (2008) Differential distribution of vasa vasorum in different vascular beds in humans. Atherosclerosis 199: 47–54
56. Hoff HF, Bradley WA, Heideman CL, Gaubatz JW, Karagas MD, Gotto AM Jr (1979) Characterization of low density lipoprotein-like particle in the human aorta from grossly normal and atherosclerotic regions. Biochim Biophys Acta 573: 361–374
57. Hossain GS, van Thienen JV, Werstuck GH (2003) TDAG51 is induced by homocysteine, promotes detachment-mediated programmed cell death, and contributes to the development of atherosclerosis in hyperhomocysteinemia. J Biol Chem278: 30317–30327
58. Ho-Tin-Noe B, Goerge T, Cifuni SM, Duerschmied D, Wagner DD (2008) Platelet granule secretion continuously prevents intratumor hemorrhage. Cancer Res 68: 6851–6858
59. Hynes RO (1992) Integrins: versatility, modulation, and signaling in cell adhesion. Cell 69: 11–25
60. Iakoubova OA, Sabatine MS, Rowland CM (2008a) Polymorphism in KIF6 gene and benefit from statins after acute coronary syndromes: results from the PROVE IT-TIMI 22 study. J Am Coll Cardiol 51: 449–455
61. Iakoubova OA, Tong CH, Rowland CM (2008b) Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials. J Am Coll Cardiol 51: 435–443
62. Ikari Y, McManus BM, Kenyon J, Schwartz SM (1999) Neonatal intima formation in the human coronary artery. Arterioscler Thromb Vasc Biol 19: 2036–2040
63. Imanishi T, McBride J, Ho Q, O'Brien KD, Schwartz SM, Han DK (2000) Expression of cellular FLICE-inhibitory protein in human coronary arteries and in a rat vascular injury model. Am J Pathol 156: 125–137
64. Katz SS, Shipley GG, Small DM (1976) Physical chemistry of the lipids of human atherosclerotic lesions. Demonstration of a lesion intermediate between fatty streaks and advanced plaques. J Clin Investig 58: 200–211
65. Kay HR, Korns ME, Flemma RJ, Tector AJ, Lepley D Jr (1976) Atherosclerosis of the internal mammary artery. Ann Thorac Surg 21: 504–507
66. Kellner-Weibel G, Yancey PG, Jerome WG (1999) Crystallization of free cholesterol in model macrophage foam cells. Arterioscler Thromb Vasc Biol 19: 1891–1898
67. Keso T, Perola M, Laippala P (2001) Polymorphisms within the tumor necrosis factor locus and prevalence of coronary artery disease in middle-aged men. Atherosclerosis 154: 691–697
68. Kolodgie FD, Narula J, Burke AP (2000) Localization of apoptotic macrophages at the site of plaque rupture in sudden coronary death. Am J Pathol 157: 1259–1268
69. Kolodgie FD, Burke AP, Farb A (2001) The thin-cap fibroatheroma: a type of vulnerable plaque: the major precursor lesion to acute coronary syndromes. Curr Opin Cardiol 16: 285–292
70. Kolodgie FD, Burke AP, Farb A (2002) Differential accumulation of proteoglycans and hyaluronan in culprit lesions: insights into plaque erosion. Arterioscler Thromb Vasc Biol 22: 1642–1648
71. Kolodgie FD, Gold HK, Burke AP (2003) Intraplaque hemorrhage and progression of coronary atheroma. N Engl J Med 349: 2316–2325
72. Kolodgie FD (2009) Pathogenesis of atherosclerosis and the unstable plaque. In: Peter O, Kwiterovich J (eds) The Johns Hopkins textbook of dyslipidemia. Lipincott Williams &Wilkins, Baltimore.
73. Kramer MC, van der Wal AC, Koch KT (2009) Histopathological features of aspirated thrombi after primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction. PLoS One 4: e5817
74. Kramer MC, Rittersma SZ, deWinter RJ (2010) Relationship of thrombus healing to underlying plaque morphology in sudden coronary death. J Am Coll Cardiol 55: 122–132
75. Lauber K, Bohn E, Krober SM (2003) Apoptotic cells induce migration of phagocytes via caspase-3-mediated release of a lipid attraction signal. Cell 113: 717–730
76. Leon ME, Chavez C, Fyfe B, Nagorsky MJ, Garcia FU (2002) Cholesterol granuloma of the maxillary sinus. Arch Pathol Lab Med 126: 217–219
77. Levy AP, Levy JE, Kalet-Litman S (2007) Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque. Arterioscler Thromb Vasc Biol 27: 134–140
78. Ley K, Laudanna C, Cybulsky MI, Nourshargh S (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 7: 678–689
79. Loop FD (1996) Internal-thoracic-artery grafts. Biologically better coronary arteries. N Engl J Med 334: 263–265
80. Loop FD, Lytle BW, Cosgrove DM (1986) Influence of the internal-mammary-artery graft on 10-year survival and other cardiac events. N Engl J Med 314: 1–6
81. Mann J, Davies MJ (1999) Mechanisms of progression in native coronary artery disease: role of healed plaque disruption. Heart (British Cardiac Society) 82: 265–268
82. Mannacio V, Di Tommaso L, Antignano A (2012) Endothelial nitric oxide synthase expression in postmenopausal women: a sex-specific risk factor in coronary surgery. Ann Thorac Surg 94: 1934–1939
83. McGill HC Jr, McMahan CA, Herderick EE (2000) Effects of coronary heart disease risk factors on atherosclerosis of selected regions of the aorta and right coronary artery. PDAY Research Group. Pathobiological Determinants of Atherosclerosis in Youth. Arterioscler Thromb Vasc Biol 20: 836–845
84. Michel JB, Virmani R, Arbustini E, Pasterkamp G (2011) Intraplaque haemorrhages as the trigger of plaque vulnerability. Eur Heart J 32: 1977–1985, 1985a, 1985b, 1985c
85. Motoyama S, Kondo T, Sarai M (2007) Multislice computed tomographic characteristics of coronary lesions in acute coronary syndromes. J AmColl Cardiol 50: 319–326
86. Motwani JG, Topol EJ (1998) Aortocoronary saphenous vein graft disease: pathogenesis, predisposition, and prevention. Circulation 97: 916–931
87. Myoishi M, Hao H, Minamino T (2007) Increased endoplasmic reticulum stress in atherosclerotic plaques associated with acute coronary syndrome. Circulation 116: 1226–1233
88. Nakashima Y, Chen YX, Kinukawa N, Sueishi K (2002) Distributions of diffuse intimal thickening in human arteries: preferential expression in atherosclerosisprone arteries from an early age. Virchows Arch 441: 279–288
89. Nakashima Y, Fujii H, Sumiyoshi S, Wight TN, Sueishi K (2007) Early human atherosclerosis: accumulation of lipid and proteoglycans in intimal thickenings followed by macrophage infiltration. Arterioscler Thromb Vasc Biol 27: 1159–1165
90. Nakashima Y, Wight TN, Sueishi K (2008) Early atherosclerosis in humans: role of diffuse intimal thickening and extracellular matrix proteoglycans. Cardiovasc Res 79: 14–23
91. Nicholls SJ, Tuzcu EM, Wolski K (2007) Coronary artery calcification and changes in atheroma burden in response to established medical therapies. J Am Coll Cardiol 49: 263–270
92. Noris M, Morigi M, Donadelli R (1995) Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res 76: 536–543
93. Ojha M, Leask RL, Johnston KW, David TE, Butany J (2000) Histology and morphology of 59 internal thoracic artery grafts and their distal anastomoses. Ann Thorac Surg 70: 1338–1344
94. Orekhov AN, Andreeva ER, Mikhailova IA, Gordon D (1998) Cell proliferation in normal and atherosclerotic human aorta: proliferative splash in lipid-rich lesions. Atherosclerosis 139: 41–48
95. Otsuka F, Yahagi K, Sakakura K, Virmani R (2013) Why is the mammary artery so special and what protects it from atherosclerosis? Ann Cardiothorac Surg 2: 519–526
96. Patterson JC (1954) The reaction of the arterial wall to intramural hemorrhage. In: Symposium of Atherosclerosis. Washington, DC: National Academy of Sciences, pp 65–73
97. Perales S, Alejandre MJ, Palomino-Morales R, Torres C, Iglesias J, Linares A (2009) Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. J Biomed Biotechnol 2009: 456208
98. Peykar S, Angiolillo DJ, Bass TA, Costa MA (2004) Saphenous vein graft disease. Minerva Cardioangiol 52: 379–390
99. Porto I, Gaudino M, De Maria GL (2013) Long-term morphofunctional remodeling of internal thoracic artery grafts: a frequency-domain optical coherence tomography study. Circ Cardiovasc Interv 6: 269–276
100. Purushothaman M, Krishnan P, Purushothaman KR (2012) Genotype-dependent impairment of hemoglobin clearance increases oxidative and inflammatory response in human diabetic atherosclerosis. Arterioscler Thromb Vasc Biol 32: 2769–2775
101. Ridker PM, Danielson E, Fonseca FA (2008) Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 359: 2195–2207
102. Sakakura K, Nakano M, Otsuka F (2013) Comparison of pathology of chronic total occlusion with and without coronary artery bypass graft. Eur Heart J. doi: 10-1093/eurheartj/eht422
103. Schrijvers DM, De Meyer GR, Kockx MM, Herman AG, Martinet W (2005) Phagocytosis of apoptotic cells by macrophages is impaired in atherosclerosis. Arterioscler Thromb Vasc Biol 25: 1256–1261
104. Schwartz RS, Burke A, Farb A (2009) Microemboli and microvascular obstruction in acute coronary thrombosis and sudden coronary death: relation to epicardial plaque histopathology. J Am Coll Cardiol 54: 2167–2173
105. Serruys PW, Morice MC, Kappetein AP (2009) Percutaneous coronary intervention versus coronary-artery bypass grafting for severe coronary artery disease. N Engl J Med 360: 961–972
106. Shelton ME, Forman MB, Virmani R, Bajaj A, Stoney WS, Atkinson JB (1988) A comparison of morphologic and angiographic findings in long-term internal mammary artery and saphenous vein bypass grafts. J Am Coll Cardiol 11: 297–307
107. Sluimer JC, Kolodgie FD, Bijnens AP (2009) Thinwalled microvessels in human coronary atherosclerotic plaques show incomplete endothelial junctions relevance of compromised structural integrity for intraplaque microvascular leakage. J Am Coll Cardiol 53: 1517–1527
108. Smith EB, Slater RS (1972) The microdissection of large atherosclerotic plaques to give morphologically and topographically defined fractions for analysis. 1. The lipids in the isolated fractions. Atherosclerosis 15: 37–56
109. Stary HC, Blankenhorn DH, Chandler AB (1992) A definition of the intima of human arteries and of its atherosclerosis-prone regions.Areport from theCommittee on Vascular Lesions of the Council onArteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol: J Vasc Biol/Am Heart Assoc 12: 120–134
110. Stary HC, Chandler AB, Dinsmore RE (1995) A definition of advanced types of atherosclerotic lesions and a histological classification of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Arterioscler Thromb Vasc Biol 15: 1512–1531
111. Sukhova GK, Schonbeck U, Rabkin E (1999) Evidence for increased collagenolysis by interstitial collagenases-1 and _3 in vulnerable human atheromatous plaques. Circulation 99: 2503–2509
112. Tabas I (2000) Cholesterol and phospholipid metabolism in macrophages. Biochim Biophys Acta 1529: 164–174
113. Tabas I (2002) Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest 110: 905–911
114. Tabas I (2005) Consequences and therapeutic implications of macrophage apoptosis in atherosclerosis: the importance of lesion stage and phagocytic efficiency. Arterioscler Thromb Vasc Biol 25: 2255–2264
115. Tabas I, Marathe S, Keesler GA, Beatini N, Shiratori Y (1996) Evidence that the initial up-regulation of phosphatidylcholine biosynthesis in free cholesterol-loaded macrophages is an adaptive response that prevents cholesterol-induced cellular necrosis. Proposed role of an eventual failure of this response in foam cell necrosis in advanced atherosclerosis. J Biol Chem 271: 22773–22781
116. Tulenko TN, Chen M, Mason PE, Mason RP (1998) Physical effects of cholesterol on arterial smooth muscle membranes: evidence of immiscible cholesterol domains and alterations in bilayer width during atherogenesis. J Lipid Res 39: 947–956
117. Van den Heuvel MM, Tensen CP, van As JH (1999) Regulation of CD 163 on human macrophages: crosslinking of CD163 induces signaling and activation. J Leukoc Biol 66: 858–866
118. van der Wal AC, Becker AE, van der Loos CM, Das PK (1994) Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89: 36–44
119. Vancov V (1973) Structural basis of the microcirculation in the wall of arterial vessels. Bibl Anat 11: 383–388
120. Velican C (1969) Relationship between regional aortic susceptibility to atherosclerosis and macromolecular structural stability. J Atheroscler Res 9: 193–201
121. Velican C (1981) A dissecting view on the role of the fatty streak in the pathogenesis of human atherosclerosis: culprit or bystander? Med Interne 19: 321–337
122. Velican D, Velican C (1980) Atherosclerotic involvement of the coronary arteries of adolescents and young adults. Atherosclerosis 36: 449–460
123. Velican C, Velican D (1982) Discrepancies between data on atherosclerotic involvement of human coronary arteries furnished by gross inspection and by light microscopy. Atherosclerosis 43: 39–49
124. Vengrenyuk Y, Carlier S, Xanthos S (2006) A hypothesis for vulnerable plaque rupture due to stress-induced debonding around cellular microcalcifications in thin fibrous caps. Proc Natl Acad Sci U S A 103: 14678–14683
125. Virmani R, Narula J, Farb A (1998) When neoangiogenesis ricochets. Am Heart J 136: 937–939
126. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20: 1262–1275
127. Virmani R, Kolodgie FD, Burke AP (2005) Atherosclerotic plaque progression and vulnerability to rupture: angiogenesis as a source of intraplaque hemorrhage. Arterioscler Thromb Vasc Biol 25: 2054–2061
128. Waller BF, Roberts WC (1985) Remnant saphenous veins after aortocoronary bypass grafting: analysis of 3,394
129. Wang TJ, Larson MG, Levy D (2002) C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study. Circulation 106: 1189–1191
130. Wartman WB (1938) Occlusion of the coronary arteries by hemorrhage into their walls. Am Heart J 15: 459–470
131. Watson KE, Abrolat ML, Malone LL (1997) Active serum vitamin D levels are inversely correlated with coronary calcification. Circulation 96: 1755–1760
132. Winternitz MC, Thomas RM, Le Compte PM (1938) Thrombosis. In: Thomas CC (ed) The biology of atherosclerosis. Charles C Thomas, Springfield, pp 94–103
133. Xu Y, Mintz GS, Tam A (2012) Prevalence, distribution, predictors, and outcomes of patients with calcified nodules in native coronary arteries: a 3-vessel intravascular ultrasound analysis from providing regional observations to Study Predictors of Events in the Coronary Tree (PROSPECT). Circulation 126: 537–545
134. Yazdani SK, Farb A, Nakano M (2012) Pathology of drug-eluting versus bare-metal stents in saphenous vein bypass graft lesions. JACC Cardiovasc Interv 5: 666–674
135. Yeagle PL (1985) Cholesterol and the cell membrane. Biochim Biophys Acta 822: 267–287
136. Zhong Y, Tang H, Zeng Q (2012) Total cholesterol content of erythrocyte membranes is associated with the severity of coronary artery disease and the therapeutic effect of rosuvastatin. Ups J Med Sci 117: 390–398