Haptoglobin genotype is a determinant of iron, lipid peroxidation, and macrophage accumulation in the atherosclerotic plaque

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 27, Issue 1, 2007, Pages 134-140

  Levy, Andrew P ^a   Levy, Joanne E ^b   Kalet Litman, Shiri ^a   Miller Lotan, Rachel ^a   Levy, Nina S ^a   Asaf, Roy ^a   Guetta, Julia ^a   Yang, Chingwen ^c   Purushothaman, K Raman ^d   Fuster, Valentin ^d   Moreno, Pedro R ^d  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c ROCKEFELLER UNIVERSITY   (United States)

^d MOUNT SINAI MEDICAL CENTER   (United States)

Author keywords

Atherosclerotic plaque; Hemoglobin; Inflammation; Iron; Macrophages

Indexed keywords

4 HYDROXYNONENAL; CEROID; HAPTOGLOBIN; IRON; LIPID; APOLIPOPROTEIN E;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; COMPARATIVE STUDY; CONTROLLED STUDY; GENE INSERTION; GENE LOCUS; GENOTYPE; HOMOLOGOUS RECOMBINATION; LIPID PEROXIDATION; MACROPHAGE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; ALLELE; ANIMAL; BLEEDING; CAROTID ARTERY OBSTRUCTION; GENETICS; HEART INFARCTION; METABOLISM; MOUSE MUTANT; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; RISK FACTOR; RUPTURE;

ALLELES; ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CAROTID STENOSIS; GENOTYPE; HAPTOGLOBINS; HEMORRHAGE; IRON; LIPID PEROXIDATION; MACROPHAGES; MICE; MICE, KNOCKOUT; MYOCARDIAL INFARCTION; RISK FACTORS; RUPTURE; RUPTURE, SPONTANEOUS;

EID: 33847671755     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000251020.24399.a2     Document Type: Article

References (34)

1. Burke AP, Farb A, Malcolm GT, Liang YH, Smialek J, Virmani R. Coronary risk factors and plaque morphology in men with coronary artery disease who die suddenly. N Engl J Med. 1997;336:1276-1282.
2. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscl Thromb Vasc Biol. 2000;20:1262-1275.
3. Fuster V, Moreno PR, Fayad ZA, Corti R, Badimon JJ. Atherothrombosis and the high-risk plaque. Part I. J Am Coll Card. 2005;46:937-944.
4. Fuster V, Fayad ZA, Moreno PR, Poon M, Corti R, Badimon JJ. Atherothrombosis and the high-risk plaque. Part II. J Am Coll Card. 2005;46:1209-1218.
5. Kolodgie FD, Gold HK, Burke AP, Fowler DR, Kruth HS, Weber DK, Farb A, Guerrero LJ, Hayase M, Kutys R, Narula J, Finn AV, Virmani R. Intraplaque hemorrhage and progression of coronary atheroma. N Eng J Med. 2003;349:2316-2325.
6. Virmani R, Kolodgie FD, Burke AP, Finn AV, Gold HK, Tulenko TN, Wrenn SP, Narula J. Atherosclerotic plaque progression and vulnerability to rupture angiogenesis as a source of intraplaque hemorrhage. Arterioscl Thromb Vasc Biol. 2005;25:2054-2061.
7. Kockx MM, Cromheeke KM, Knaapen MWM, Bosmans JM, De Meyer GRY, Herman AG, Bult H. Phagocytosis and macrophage activation associated with hemorrhagic microvessels in human atherosclerosis. Arterioscl Thromb Vasc Biol. 2003;23:440-446.
8. Bowman BH, Kurosky A. Haptoglobin: the evolutionary product of duplication, unequal crossing over, and point mutation. Adv Hum Genet. 1982;12:189-261.
9. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK. Identification of the hemoglobin scavenger receptor. Nature. 2001;409:198-201.
10. Langlois MR, Delanghe JR. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem. 1996;42:1589-1600.
11. Levy AP, Hochberg I, Jablonski K, Resnick H, Best L, Lee ET, Howard BV. Haptoglobin phenotype and the risk of cardiovascular disease in individuals with diabetes: The Strong Heart Study. J Am Coll Card. 2002;40:1984-1990.
12. Roguin A, Koch W, Kastrati A, Aronson D, Schomig A, Levy AP. Haptoglobin genotype is predictive of major adverse cardiac events in the one year period after PTCA in individuals with diabetes. Diabetes Care. 2003;26:2628-2631.
13. Suleiman M, Aronson D, Asleh R, Kapelovich MR, Roguin A, Meisel SR, Shochat M, Suleiman A, Reisner SA, Markiewicz W, Hammerman H, Lotan R, Levy NS, Levy AP. Haptoglobin polymorphism predicts 30-day mortality and heart failure in patients with diabetes and acute myocardial infarction. Diabetes. 2005;19:2802-2806.
14. Frank M, Lache O, Enav B, Szafranek T, Levy NS, Ricklis RM, Levy AP. Structure/function analysis of the anti-oxidant properties of haptoglobin. Blood. 2001;98:3693-3698.
15. Asleh R, Guetta J, Kalet-Litman S, Miller-Lotan R, Levy AP. Haptoglobin genotype and diabetes dependent differences in iron mediated oxidative stress in vitro and in vivo. Circ Res. 2005;96:435-441.
16. Asleh R, Marsh S, Shiltruck M, Binah O, Guetta J, Lejbkowicz F, Enav B, Shehadeh N, Kanter Y, Lache O, Cohen O, Levy NS, Levy AP. Genetically determined heterogeneity in hemoglobin scavenging and susceptibility to diabetic cardiovascular disease. Circ Res. 2003;92:1193-1200.
17. Philippidis P, Mason JC, Evans BJ, Nadra I, Taylor KM, Haskard DO, Landis RC. Hemoglobin scavenger receptor CD163 mediates interleukin 10 release and heme oxygenase-1 synthesis: anti-inflammatory monocyte-macrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res. 2004;94:119-126.
18. Philippidis P, Boyle JJ, Domin J, Nadra I, Haskard DO, Taylor KM Anti-inflammatory hemoglobin scavenging macrophages in atherosclerotic plaques: a potential atheroprotective role. Circ. 2005;112:431(abstract).
19. Guetta J, Strauss M, Levy NS, Fahoum L, Levy AP. Haptoglobin genotype modulates the balance of Th1/Th2 cytokines produced by macrophages exposed to free hemoglobin. Atherosclerosis. In press.
20. Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nature Genetics. 1999;21:396-399.
21. Moreno PR, Purushothaman KR, Fuster V, O'Connor WN. Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability. Circulation. 2002;105:2504-2511.
22. Moreno PR, Lodder RA, Purushothaman KR, Charash WE, O'Connor WN, Muller JE. Detection of lipid pool, thin fibrous cap, and inflammatory cells in human aortic atherosclerotic plaques by near-infrared spectroscopy. Circulation. 2002;105:923-927.
23. Esterbauer H, Schaur RJ, Zollner H. Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde, and related aldehydes. Free Rad Biol Med. 1991;11:81-128.
24. Wejman JC, Hovsepian D, Wall JS, Hainfeld JF, Greer J. Structure and assembly of haptoglobin polymers by electron microscopy. J Mol Biol. 1984;174:343-368.
25. Schaur RJ, Zollner H, Esterbauer H. Biological effects of aldehydes with particular attention to 4-hydroxynenal and malondialdehyde. In: Vigo-Pelfrey C, ed. Membrane lipid peroxidation. Boca-Raton, Fl: CRC Press; 1997:141-153.
26. Witztum TN. The oxidation hypothesis of atherosclerosis. Lancet. 1994;344:793-795.
27. Blum S, Asaf R, Guetta J, Miller-Lotan R, Asleh R, Kremer R, Levy NS, Berger FG, Fu X, Zhang R, Hazen SL, Levy AP. Haptoglobin genotype determines myocardial infarct size in diabetic mice. J Am Coll Card 2000; in press.
28. Lee FY, Lee TS, Pan CC, Huang AL, Chau LY. Colocalization of iron and ceroid in human atherosclerotic lesions. Atherosclerosis. 1998;138:281-288.
29. Mallat Z, Heymes C, Ohan J, Faggin E, Leseche G, Tedgui A. Expression of interleukin-10 in advanced human atherosclerotic plaques. Arterioscler Thromb Vasc Biol. 1999;19:611-616.
30. Potteaux S, Esposito B, Oostrom OV, Brun V, Ardouin P, Groux H, Tedgui A, Mallat Z. Leukocyte derived interleukin 10 is required for protection against atherosclerosis in low density lipoprotein receptor knockout mice. Arterioscler Thromb Vasc Biol. 2004;24:1474-1478.
31. Waehre T, Halvorsen B, Damas JK, Yndestad A, Brosstad F, Gullestad L, Kjekshus J, Froland SS, Aukrust P. Inflammatory imbalance between Il-10 and TNFa in unstable angina potential plaque stabilizing effects of Il-10. Eur J Clin Invest. 2002;32:803-810.
32. Burke AP, Kolodgie FD, Zieske A, Fowler DR, Weber DK, Varghese PJ, Farb A, Virmani R. Morphologic findings of coronary artery plaques in diabetics. Arterioscler Thromb Vasc Biol. 2004;24:1266-1271.
33. Moreno P, Fuster V. New aspects in the pathogenesis of diabetic atherosclerosis. J Am Coll Card. 2005;44:2293-2300.
34. Levy AP, Gerstein HC, Miller-Lotan R, Ratner R, McQueen M, Lonn E, Pogue J. The effect of vitamin E supplementation on cardiovascular risk in diabetic individuals with different haptoglobin phenotypes. Diab Care. 2004;27:2767.