Changes in methionine metabolism and histone H3 trimethylation are linked to mitochondrial defects in multiple sclerosis

Journal of Neuroscience

Volumn 35, Issue 45, 2015, Pages 15170-15186

  Singhal, Naveen Kumar ^a   Li, Shuo ^a   Arning, Erland ^c   Alkhayer, Kholoud ^a   Clements, Robert ^a   Sarcyk, Zachary ^a   Dassanayake, Rohan S ^a   Brasch, Nicola E ^b   Freeman, Ernest J ^a   Bottiglieri, Teodoro ^c   McDonough, Jennifer ^a  

^a KENT STATE UNIVERSITY   (United States)

^b AUCKLAND UNIVERSITY OF TECHNOLOGY   (New Zealand)

^c BAYLOR UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Betaine; Betaine homocysteine methyltransferase; Epigenetics; Methionine metabolism; Mitochondria; Multiple sclerosis

Indexed keywords

BETAINE HOMOCYSTEINE METHYLTRANSFERASE; CYSTATHIONINE BETA SYNTHASE; HISTONE H3; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; METHIONINE SYNTHASE; PROTEOLIPID PROTEIN; HISTONE;

ADULT; AMINO ACID METABOLISM; ARTICLE; CENTRAL GRAY MATTER; CHROMATIN IMMUNOPRECIPITATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTONE METHYLATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LIQUID CHROMATOGRAPHY; MALE; MOTOR CORTEX; MULTIPLE SCLEROSIS; PARIETAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIROMETRY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TANDEM MASS SPECTROMETRY; WESTERN BLOTTING; BRAIN; METABOLISM; METHYLATION; MITOCHONDRION; PATHOLOGY; TUMOR CELL LINE;

ADULT; BRAIN; CELL LINE, TUMOR; FEMALE; HISTONES; HUMANS; MALE; METHIONINE; METHYLATION; MITOCHONDRIA; MULTIPLE SCLEROSIS;

EID: 84946944730     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4349-14.2015     Document Type: Article

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