Indirect evidence for early widespread gray matter involvement in relapsing-remitting multiple sclerosis

NeuroImage

Volumn 21, Issue 4, 2004, Pages 1825-1829

  Inglese, Matilde ^a   Ge, Yulin ^a   Filippi, Massimo ^b   Falini, Andrea ^b   Grossman, Robert I ^a   Gonen, Oded ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Gray matter; Multiple sclerosis; N acetylaspartate

Indexed keywords

N ACETYLASPARTIC ACID;

ADULT; ARTICLE; BRAIN INJURY; BRAIN SIZE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE COURSE; FEMALE; GRAY MATTER; HUMAN; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NERVE CELL; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PARENCHYMA; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SEX DIFFERENCE; STANDARD; STATISTICAL ANALYSIS;

ADULT; ASPARTIC ACID; AXONS; BRAIN; BRAIN MAPPING; DOMINANCE, CEREBRAL; ENERGY METABOLISM; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; NEURONS; REFERENCE VALUES;

EID: 1842608971     PISSN: 10538119     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroimage.2003.12.008     Document Type: Article

References (46)

1. Allen I.V., McKeown S.R. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J. Neurol. Sci. 41:1979;81-91.
2. Arnold D.L., Matthews P.M., Francis G., Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluations of multiple sclerosis: assessment of the load of disease. Magn. Reson. Med. 14:1990;154-159.
3. Arnold D.L., De Stefano N., Narayanan S., Matthews P.M. Proton MR spectroscopy in multiple sclerosis. Neuroimaging Clin. N. Am. 10:2000;789-798. (ix-x).
4. Bjartmar C., Kidd G., Mork S., Rudick R., Trapp B.D. Neurological disability correlates with spinal cord axonal loss and reduced N-acetyl aspartate in chronic multiple sclerosis patients. Ann. Neurol. 48:2000;893-901.
5. Bjartmar C., Kinkel R.P., Kidd G., Rudick R.A., Trapp B.D. Axonal loss in normal-appearing white matter in a patient with acute MS. Neurology. 57:2001;1248-1252.
6. Blinkenberg M., Rune K., Jensen C.V., Ravnborg M., Kyllingsbaek S., Holm S.et al. Cortical cerebral metabolism correlates with MRI lesion load and cognitive dysfunction in MS. Neurology. 54:2000;558-564.
7. Bozzali M., Cercignani M., Sormani M.P., Comi G., Filippi M. Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging. AJNR Am. J. Neuroradiol. 23:2002;985-988.
8. Brownell B., Hughes J. The distribution of plaques in the cerebrum in multiple sclerosis. J. Neurol., Neurosurg. Psychiatry. 25:1962;315-320.
9. Charcot, J., 1868. Histologie de le sclerose en plaques. Gaz Hop (Paris) 141 554-555, 557-558.
10. Chard D.T., Griffin C.M., McLean M.A., Kapeller P., Kapoor R., Thompson A.J.et al. Brain metabolite changes in cortical grey and normal-appearing white matter in clinically early relapsing-remitting multiple sclerosis. Brain. 125:2002;2342-2352.
11. Chard D.T., Griffin C.M., Parker G.J., Kapoor R., Thompson A.J., Miller D.H. Brain atrophy in clinically early relapsing-remitting multiple sclerosis. Brain. 125:2002;327-337.
12. Cifelli A., Arridge M., Jezzard P., Esiri M.M., Palace J., Matthews P.M. Thalamic neurodegeneration in multiple sclerosis. Ann. Neurol. 52:2002;650-653.
13. Courchesne E., Chisum H.J., Townsend J., Cowles A., Covington J., Egaas B.et al. Normal brain development and aging: quantitative analysis at in vivo MR imaging in healthy volunteers. Radiology. 216:2000;672-682.
14. Davie C.A., Hawkins C.P., Barker G.J., Brennan A., Tofts P.S., Miller D.H.et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain. 117:1994;49-58.
15. De Stefano N., Narayanan S., Mortilla M., Guidi L., Bartolozzi M.L., Federico A.et al. Imaging axonal damage in multiple sclerosis by means of MR spectroscopy. Neurol. Sci. 21:2000;S883-S887.
16. De Stefano N., Matthews P.M., Filippi M., Agosta F., De Luca M., Bartolozzi M.L.et al. Evidence of early cortical atrophy in MS: relevance to white matter changes and disability. Neurology. 60:2003;1157-1162.
17. Evangelou N., Esiri M.M., Smith S., Palace J., Matthews P.M. Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis. Ann. Neurol. 47:2000;391-395.
18. Filippi M., Cercignani M., Inglese M., Horsfield M.A., Comi G. Diffusion tensor magnetic resonance imaging in multiple sclerosis. Neurology. 56:2001;304-311.
19. Filippi M., Bozzali M., Rovaris M., Gonen O., Kesavadas C., Ghezzi A.et al. Evidence for widespread axonal damage at the earliest clinical stage of multiple sclerosis. Brain. 126:2003;433-437.
20. Fu L., Matthews P.M., De Stefano N., Worsley K.J., Narayanan S., Francis G.S.et al. Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain. 121:1998;103-113.
21. Ge Y., Grossman R.I., Udupa J.K., Wei L.G., Mannon L.J., Polansky M.et al. Brain atrophy in relapsing-remitting multiple sclerosis and secondary progressive multiple sclerosis: longitudinal quantitative analysis. Radiology. 214:2000;665-670.
22. Ge Y., Grossman R.I., Udupa J.K., Babb J.S., Kolson D.L., McGowan J.C. Magnetization transfer ratio histogram analysis of gray matter in relapsing-remitting multiple sclerosis. AJNR Am. J. Neuroradiol. 22:2001;470-475.
23. Gonen O., Viswanathan A.K., Catalaa I., Babb J., Udupa J., Grossman R.I. Total brain N-acetylaspartate concentration in normal, age-grouped females: quantitation with non-echo proton NMR spectroscopy. Magn. Reson. Med. 40:1998;684-689.
24. Gonen O., Catalaa I., Babb J.S., Ge Y., Mannon L.J., Kolson D.L.et al. Total brain N-acetylaspartate: a new measure of disease load in MS. Neurology. 54:2000;15-19.
25. Kapeller P., McLean M.A., Griffin C.M., Chard D., Parker G.J., Barker G.J.et al. Preliminary evidence for neuronal damage in cortical grey matter and normal appearing white matter in short duration relapsing-remitting multiple sclerosis: a quantitative MR spectroscopic imaging study. J. Neurol. 248:2001;131-138.
26. Kidd D., Barkhof F., McConnell R., Algra P.R., Allen I.V., Revesz T. Cortical lesions in multiple sclerosis. Brain. 122:1999;17-26.
27. Kurtzke J.F. Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 33:1983;1444-1452.
28. Li B.S., Babb J.S., Soher B.J., Maudsley A.A., Gonen O. Reproducibility of 3D proton spectroscopy in the human brain. Magn. Reson. Med. 47:2002;439-446.
29. Loevner L.A., Grossman R.I., Cohen J.A., Lexa F.J., Kessler D., Kolson D.L. Microscopic disease in normal-appearing white matter on conventional MR images in patients with multiple sclerosis: assessment with magnetization- transfer measurements. Radiology. 196:1995;511-515.
30. Lublin F.D., Reingold S.C. Defining the clinical course of multiple sclerosis: results of an international survey. National multiple sclerosis society (USA) advisory committee on clinical trials of new agents in multiple sclerosis. Neurology. 46:1996;907-911.
31. Lumsden C. The neuropathology of multiple sclerosis. Vinken P.j.B.G. Handbook of Clinical Neurology. vol. 9:1970;217-309 North-Holland, Amsterdam.
32. Matthews P.M., Pioro E., Narayanan S., De Stefano N., Fu L., Francis G. et al. Assessment of lesion pathology in multiple sclerosis using quantitative MRI morphometry and magnetic resonance spectroscopy. Brain. 119:1996;715-722.
33. Miki Y., Grossman R.I., Udupa J.K., van Buchem M.A., Wei L., Phillips M.D.et al. Differences between relapsing-remitting and chronic progressive multiple sclerosis as determined with quantitative MR imaging. Radiology. 210:1999;769-774.
34. Miki Y., Grossman R.I., Udupa J.K., Wei L., Polansky M., Mannon L.J.et al. Relapsing-remitting multiple sclerosis: longitudinal analysis of MR images - Lack of correlation between changes in T2 lesion volume and clinical findings. Radiology. 213:1999;395-399.
35. Narayana P.A., Doyle T.J., Lai D., Wolinsky J.S. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann. Neurol. 43:1998;56-71.
36. Peterson J.W., Bo L., Mork S., Chang A., Trapp B.D. Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions. Ann. Neurol. 50:2001;389-400.
37. Rao S.M., Leo G.J., Bernardin L., Unverzagt F. Cognitive dysfunction in multiple sclerosis: I. Frequency, patterns, and prediction. Neurology. 41:1991;685-691.
38. Samarasekera S., Udupa J.K., Miki Y., Wei L., Grossman R.I. A new computer-assisted method for the quantification of enhancing lesions in multiple sclerosis. J. Comput. Assist. Tomogr. 21:1997;145-151.
39. Sharma R., Narayana P.A., Wolinsky J.S. Grey matter abnormalities in multiple sclerosis: proton magnetic resonance spectroscopic imaging. Mult. Scler. 7:2001;221-226.
40. Simmons M.L., Frondoza C.G., Coyle J.T. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 45:1991;37-45.
41. Trapp B.D., Peterson J., Ransohoff R.M., Rudick R., Mork S., Bo L. Axonal transection in the lesions of multiple sclerosis. N. Engl. J. Med. 338:1998;278-285.
42. Udupa J.K., Samarasekera S. Fuzzy connectedness and object definition: theory, algorithms, and applications in image segmentation. Graph. Models Image Proc. 58:1996;246-261.
43. Udupa J.K., Odhner D., Samarasekera S. 3DVIEWNIX: an open, transportable, multidimensional, multimodality, multiparametric imaging software system. Proc. SPIE. 2164:1994;58-73.
44. Udupa J.K., Wei L., Miki Y., Grossman R.I. A system for the comprehensive analysis of multiple sclerosis lesion load based on MR imagery. Proceedings of the Society of Photo-optical Instrumentation Engineers. vol. 3031:1997;610-618 SPIE Publishing Services, Bellingham, WA. Newport Beach, CA.
45. van Walderveen M.A., Barkhof F., Pouwels P.J., van Schijndel R.A., Polman C.H., Castelijns J.A. Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Ann. Neurol. 46:1999;79-87.
46. Wang Y., Li S.J. Differentiation of metabolic concentrations between gray matter and white matter of human brain by in vivo 1H magnetic resonance spectroscopy. Magn. Reson. Med. 39:1998;28-33.