Nitric Oxide Inhibits Methionine Synthase Activity in Vivo and Disrupts Carbon Flow through the Folate Pathway

Journal of Biological Chemistry

Volumn 276, Issue 29, 2001, Pages 27296-27303

  Danishpajooh, Idrees O ^a   Gudi, Tanima ^a   Chen, Yongchang ^a   Kharitonov, Vladimir G ^b   Sharma, Vijay S ^a   Boss, Gerry R ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SkyePharma Inc   (United States)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CARBON; CATALYST ACTIVITY; CELLS; METABOLISM; SYNTHESIS (CHEMICAL);

COBALAMIN; COFACTORS;

ENZYMES;

5 METHYLTETRAHYDROFOLIC ACID; CARBON; CARBON 14; CYANOCOBALAMIN; CYSTEINE; FOLIC ACID; FORMIC ACID; HEME; HOMOCYSTEINE; IRON; METHIONINE; METHIONINE SYNTHASE; NITRIC OXIDE; PURINE; PURINE NUCLEOTIDE; SERINE; 5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE DONOR;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL CULTURE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INHIBITION; FLOW KINETICS; FOLATE METABOLISM; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RAT; SPECTROSCOPY; ANIMAL; BIOSYNTHESIS; CELL LINE; COCULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; HAMSTER; HUMAN; METABOLISM; PHYSIOLOGY; VASCULAR ENDOTHELIUM;

ANIMALIA; MAMMALIA;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ANIMALS; CARBON; CELL LINE; COCULTURE TECHNIQUES; CRICETINAE; ENDOTHELIUM, VASCULAR; FOLIC ACID; HUMANS; METHIONINE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE DONORS; PURINE NUCLEOTIDES; RATS; SERINE; VITAMIN B 12;

EID: 0035920147     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M104043200     Document Type: Article

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