Mechanism of action of panaxytriol on midazolam 1′-hydroxylation and 4-hydroxylation mediated by CYP3A in liver microsomes and rat primary hepatocytes

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 10, 2015, Pages 1470-1477

  He, Fang ^a,b   Zhang, Wen ^a   Zeng, Caiwen ^a,b   Xia, Chunhua ^a   Xiong, Yuqing ^a   Zhang, Hong ^a   Huang, Shibo ^a   Liu, Mingyi ^a  

^a NANCHANG UNIVERSITY   (China)

^b Jiangxi Province Cancer Hospital   (China)

Author keywords

Cytochrome P450 3A; Differential effect mechanism; Midazolam hydroxylation metabolism; Panaxytriol

Indexed keywords

CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; MESSENGER RNA; MIDAZOLAM; PANAXYTRIOL; 1-HYDROXYMETHYLMIDAZOLAM; 4-HYDROXYMIDAZOLAM; CYTOCHROME P450 3A; CYTOCHROME P450 3A INHIBITOR; DEXAMETHASONE; ENEDIYNE; FATTY ALCOHOL; KETOCONAZOLE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG DETERMINATION; DRUG INHIBITION; DRUG MECHANISM; DRUG METABOLISM; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYDROXYLATION; LIVER CELL; LIVER MICROSOME; METABOLIC RATE; NONHUMAN; PROTEIN EXPRESSION; RAT; ANALOGS AND DERIVATIVES; ANIMAL; DRUG EFFECTS; METABOLISM;

ANIMALS; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 CYP3A INHIBITORS; DEXAMETHASONE; ENEDIYNES; FATTY ALCOHOLS; HEPATOCYTES; HUMANS; HYDROXYLATION; KETOCONAZOLE; MICROSOMES, LIVER; MIDAZOLAM; RATS; RNA, MESSENGER;

EID: 84946925065     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00143     Document Type: Article

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