Identification of the active components in shenmai injection that differentially affect Cyp3a4-mediated 1′-hydroxylation and 4-hydroxylation of midazolam

Drug Metabolism and Disposition

Volumn 41, Issue 4, 2013, Pages 785-790

  Zeng, Caiwen ^a   He, Fang ^a   Xia, Chunhua ^a,b   Zhang, Hong ^a   Xiong, Yuqing ^a  

^a NANCHANG UNIVERSITY   (China)

^b Jiangxi Province Cancer Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A4; HERBACEOUS AGENT; MIDAZOLAM; PANAXYTRIOL; RECOMBINANT CYTOCHROME P450 3A4; RECOMBINANT ENZYME; SHENMAI INJECTION; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IN VITRO STUDY; LIPID SOLUBILITY; LIVER MICROSOME; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; CYTOCHROME P-450 CYP3A; DRUG COMBINATIONS; DRUGS, CHINESE HERBAL; ENEDIYNES; FATTY ALCOHOLS; HERB-DRUG INTERACTIONS; HUMANS; HYDROXYLATION; INJECTIONS; MICROSOMES, LIVER; MIDAZOLAM; PLANT EXTRACTS; RATS;

RATTUS;

EID: 84875818077     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.112.048025     Document Type: Article

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