Study of the upregulation of the activity of cytochrome P450 3A isoforms by Astragalus injection and Astragalus granules in rats and in cells

European Journal of Drug Metabolism and Pharmacokinetics

Volumn 38, Issue 2, 2013, Pages 105-113

  Zhang, Yongli ^a,b   Huang, Ling ^c   Bi, Huichang ^c   Cui, Yuqiang ^a,b   Li, Jingqing ^c   Wang, Xiangsheng ^a,b   Qin, Xiaoling ^c   Chen, Jiangying ^c   Huang, Min ^c  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

^b Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances   (China)

^c SUN YAT SEN UNIVERSITY   (China)

Author keywords

Astragalus granules (AG); Astragalus injection (AI); CYP3A1 isoform; CYP3A4 isoform; Cytochrome P450 3A (CYP3A); Induction

Indexed keywords

ASTRAGALUS EXTRACT; CYTOCHROME P450 3A; DEXAMETHASONE; LUCIFERASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DOSAGE FORM COMPARISON; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME INDUCTION; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PROMOTER REGION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; RNA ISOLATION; TANDEM MASS SPECTROMETRY; TRANSACTIVATION; UPREGULATION;

ANIMALS; ASTRAGALUS PLANT; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INJECTIONS; ISOENZYMES; MALE; MICROSOMES, LIVER; RATS; RATS, SPRAGUE-DAWLEY; UP-REGULATION;

EID: 84878658562     PISSN: 03787966     EISSN: 21070180     Source Type: Journal    
DOI: 10.1007/s13318-012-0102-0     Document Type: Article

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