Identifying and quantifying two ligand-binding sites while imaging native human membrane receptors by AFM

Nature Communications

Volumn 6, Issue , 2015, Pages

  Pfreundschuh, Moritz ^a   Alsteens, David ^a   Wieneke, Ralph ^b   Zhang, Cheng ^c,d   Coughlin, Shaun R ^e   Tampé, Robert ^b   Kobilka, Brian K ^c   Müller, Daniel J ^a  

^a ETH ZURICH   (Switzerland)

^b GOETHE UNIVERSITY   (Germany)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NITRILOTRIACETIC ACID; POLYHISTIDINE TAG; PROTEINASE ACTIVATED RECEPTOR; PROTEOLIPOSOME; LIGAND; PROTEIN BINDING; PROTEINASE ACTIVATED RECEPTOR 1;

ACETIC ACID; ATOMIC FORCE MICROSCOPY; CELLS AND CELL COMPONENTS; IDENTIFICATION METHOD; IMAGING METHOD; LIGAND; MEMBRANE; PEPTIDE; QUANTITATIVE ANALYSIS;

ARTICLE; ATOMIC FORCE MICROSCOPY; BINDING SITE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; HUMAN; IN VITRO STUDY; LIGAND BINDING; LIPID MEMBRANE; MOLECULAR IMAGING; MOLECULAR INTERACTION; QUANTITATIVE ANALYSIS; SURFACE PROPERTY; CHEMISTRY; MOLECULAR MODEL; PROCEDURES; PROTEIN CONFORMATION;

BINDING SITES; HUMANS; LIGANDS; MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTOR, PAR-1;

EID: 84946924432     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9857     Document Type: Article

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