Osthole upregulates BDNF to enhance adult hippocampal neurogenesis in APP/PS1 transgenic mice

Biological and Pharmaceutical Bulletin

Volumn 38, Issue 10, 2015, Pages 1439-1449

  Liu, Hong ^a   Xue, Xinhong ^a   Shi, Huijian ^b   Qi, Lifeng ^a   Gong, Dianrong ^a  

^a Liaocheng Hospital   (China)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY   (China)

Author keywords

Amyloid precursor protein (APP) mouse; Brain derived neurotrophic factor (BDNF); Neurogenesis; Osthole; Presenilin 1 (PS1) transgenic mouse

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; OSTHOLE; PRESENILIN 1; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; COUMARIN DERIVATIVE; CREB1 PROTEIN, MOUSE; NEUROPROTECTIVE AGENT; PEPTIDE FRAGMENT; PRESENILIN 1, MOUSE;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; DENTATE GYRUS; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; LATENT PERIOD; MALE; MORRIS WATER MAZE TEST; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROPROTECTION; NONHUMAN; PASSIVE AVOIDANCE TEST; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SPATIAL MEMORY; TRANSGENIC MOUSE; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; AVOIDANCE BEHAVIOR; BIOSYNTHESIS; C57BL MOUSE; DISEASE MODEL; DRUG EFFECTS; GENETICS; MAZE TEST; MEMORY; METABOLISM; PHYSIOLOGY;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; COUMARINS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; MALE; MAZE LEARNING; MEMORY; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROGENESIS; NEUROPROTECTIVE AGENTS; PEPTIDE FRAGMENTS; PRESENILIN-1; UP-REGULATION;

EID: 84946903676     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b15-00013     Document Type: Article

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