Deciphering the inhibitory mechanism of genistein on xanthine oxidase in vitro

Journal of Photochemistry and Photobiology B: Biology

Volumn 153, Issue , 2015, Pages 463-472

  Lin, Suyun ^a   Zhang, Guowen ^a   Pan, Junhui ^a   Gong, Deming ^b  

^a NANCHANG UNIVERSITY   (China)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Competitive inhibitor; Genistein; Inhibition mechanism; Molecular simulation; Multispectroscopic methods; Xanthine oxidase

Indexed keywords

GENISTEIN; XANTHINE OXIDASE; ALLOPURINOL; ENZYME INHIBITOR; PROTEIN BINDING;

ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BINDING; DRUG HYDROXYLATION; ENZYME ACTIVITY; ENZYME KINETICS; FLUORESCENCE SPECTROSCOPY; GENETIC ALGORITHM; HUMAN; HYDROGEN BOND; IC50; IN VITRO STUDY; INFRARED SPECTROSCOPY; INHIBITION CONSTANT; INHIBITION KINETICS; MOLECULAR DOCKING; PRIORITY JOURNAL; PROTEIN SECONDARY STRUCTURE; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BINDING SITE; CHEMICAL PHENOMENA; CHEMISTRY; CIRCULAR DICHROISM; ENZYME ACTIVE SITE; KINETICS; METABOLISM; SPECTROFLUOROMETRY; THERMODYNAMICS;

ALLOPURINOL; BINDING SITES; BINDING, COMPETITIVE; CATALYTIC DOMAIN; CIRCULAR DICHROISM; ENZYME INHIBITORS; GENISTEIN; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMODYNAMICS; XANTHINE OXIDASE;

EID: 84946811740     PISSN: 10111344     EISSN: 18732682     Source Type: Journal    
DOI: 10.1016/j.jphotobiol.2015.10.022     Document Type: Article

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