An extremely potent inhibitor of xanthine oxidoreductase: Crystal structure of the enzyme-inhibitor complex and mechanism of inhibition

Journal of Biological Chemistry

Volumn 278, Issue 3, 2003, Pages 1848-1855

  Okamoto, Ken ^a   Eger, Bryan T ^b   Nishino, Tomoko ^a   Kondo, Shiro ^c   Pai, Emil F ^b,d   Nishino, Takeshi ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b UNIVERSITY OF TORONTO   (Canada)

^c TEIJIN LTD   (Japan)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOCIATION; FLUORESCENCE; HYDROGEN BONDS; ORGANIC ACIDS; SUBSTRATES; TITRATION;

COFACTORS;

ENZYME INHIBITION;

FEBUXOSTAT; UNCLASSIFIED DRUG; XANTHINE DEHYDROGENASE; XANTHINE OXIDASE INHIBITOR; ENZYME INHIBITOR; THIAZOLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; COMPLEX FORMATION; DISSOCIATION CONSTANT; DRUG MECHANISM; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; FLUORESCENCE; HYDROGEN BOND; INHIBITION KINETICS; PRIORITY JOURNAL; STEADY STATE; TITRIMETRY; ANIMAL; CATTLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; ENZYMOLOGY; KINETICS; MILK; SPECTROFLUOROMETRY; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATTLE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; KINETICS; MILK; MODELS, MOLECULAR; MOLECULAR STRUCTURE; SPECTROMETRY, FLUORESCENCE; THIAZOLES; XANTHINE DEHYDROGENASE;

EID: 0037449776     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208307200     Document Type: Article

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