GPR139, an orphan receptor highly enriched in the habenula and septum, is activated by the essential amino acids L-tryptophan and L-phenylalanine s

Molecular Pharmacology

Volumn 88, Issue 5, 2015, Pages 911-925

  Liu, Changlu ^a   Bonaventure, Pascal ^a   Lee, Grace ^a   Nepomuceno, Diane ^a   Kuei, Chester ^a   Wu, Jiejun ^a   Li, Qingqin ^a   Joseph, Victory ^a   Sutton, Steven W ^a   Eckert, William ^a   Yao, Xiang ^a   Yieh, Lynn ^a   Dvorak, Curt ^a   Carruthers, Nicholas ^a   Coate, Heather ^a   Yun, Sujin ^a   Dugovic, Christine ^a   Harrington, Anthony ^a   Lovenberg, Timothy W ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

1 METHYL LEVO TRYPTOPHAN; 2F LEVO PHENYLALANINE; 3 CHLORO N [2 OXO 2 [(1 PHENYLETHYL)AMINO]ETHYL]BENZAMIDE; 3,5 DIMETHOXYBENZOIC ACID 2 [(1 NAPHTHALENYLAMINO)CARBONYL]HYDRAZIDE; 3CL DEXTRO PHENETHYLAMINE; 3F LEVO PHENYLALANINE; 4BR DEXTRO PHENYLALANINE; 4BR LEVO PHENYLALANINE; 4CL DEXTRO PHENETHYLAMINE; 4CL LEVO PHENETHYLAMINE; 4F DEXTRO PHENYLALANINE; 4F LEVO PHENYLALANINE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMPHETAMINE; BENZAMIDE DERIVATIVE; FENCLONINE; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 139; INDOXIMOD; JNJ 63770044; PHENETHYLAMINE; PHENYLALANINE; PHENYLALANINE DERIVATIVE; RECOMBINANT RECEPTOR; SMALL MOLECULE TRANSPORT AGENT; TRYPTAMINE; TRYPTOPHAN; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; [2 [[4 METHOXY 6 [(3 METHOXYPROPYL)AMINO] 1,3,5 TRIAZIN 2 YL]AMINO] 4 PHENYLTHIAZOL 5 YL][4 (PYRIMIDIN 2 YL)PIPERAZIN 1 YL]METHANONE; GPR139 PROTEIN, HUMAN; NERVE PROTEIN;

AGONIST POTENCY; AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; CALCIUM MOBILIZATION ASSAY; CELL MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; EC50; EMBRYO; HABENULA; HEK293 CELL LINE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOPHYSIS; IMMUNOHISTOCHEMISTRY; MALE; MAP KINASE ASSAY; MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR AFFINITY; RNA SEQUENCE; SEPTUM PELLUCIDUM; SEQUENCE ALIGNMENT; SERUM; AGONISTS; ANIMAL; BLOOD; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; DRUG EFFECTS; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

AMINO ACID SEQUENCE; ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; HABENULA; HEK293 CELLS; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; PHENYLALANINE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; SEPTUM OF BRAIN; TRYPTOPHAN;

EID: 84946749027     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.115.100412     Document Type: Article

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