Computer-aided discovery of aromatic l-α-amino acids as agonists of the orphan G protein-coupled receptor GPR139

Journal of Chemical Information and Modeling

Volumn 54, Issue 6, 2014, Pages 1553-1557

  Isberg, Vignir ^a   Andersen, Kirsten B ^a,b,d   Bisig, Christoph ^a   Dietz, Gunnar P H ^b,c   Bräuner Osborne, Hans ^a   Gloriam, David E ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

^c DR WILLMAR SCHWABE GMBH AND CO KG   (Germany)

^d Danish Animal Experiments Inspectorate   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC COMPOUNDS; PEPTIDES;

ALPHA-AMINO ACIDS; CENTRAL NERVOUS SYSTEMS; COMPUTER AIDED; G PROTEIN COUPLED RECEPTORS; L-PHENYLALANINE; PHARMACOPHORE MODELING; POTENTIAL LIGAND; PROTEINOGENIC;

AMINO ACIDS;

AROMATIC AMINO ACID; DIPEPTIDE; G PROTEIN COUPLED RECEPTOR; GPR139 PROTEIN, HUMAN; NERVE PROTEIN; PHENYLALANINE; TRYPTOPHAN;

AGONISTS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER AIDED DESIGN; DRUG DESIGN; HEK293 CELL LINE; HUMAN; METABOLISM;

AMINO ACIDS, AROMATIC; COMPUTER-AIDED DESIGN; DIPEPTIDES; DRUG DESIGN; HEK293 CELLS; HUMANS; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PHENYLALANINE; RECEPTORS, G-PROTEIN-COUPLED; TRYPTOPHAN;

EID: 84903316641     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci500197a     Document Type: Article

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