High-throughput screening of antagonists for the orphan G-protein coupled receptor GPR139

Acta Pharmacologica Sinica

Volumn 36, Issue 7, 2015, Pages 874-878

  Wang, Jia ^a   Zhu, Lin Yun ^a   Liu, Qing ^a   Hentzer, Morten ^b   Smith, Garrick Paul ^b   Wang, Ming Wei ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b H LUNDBECK A S   (Denmark)

Author keywords

antagonist; calcium mobilization assay; GPR139; high throughput screening; orphan G protein coupled receptor

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; GPR 139; UNCLASSIFIED DRUG; CALCIUM; G PROTEIN COUPLED RECEPTOR; GPR139 PROTEIN, HUMAN; NERVE PROTEIN;

ARTICLE; CALCIUM MOBILIZATION ASSAY; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; ANIMAL; ANTAGONISTS AND INHIBITORS; CHO CELL LINE; CRICETULUS; DOSE RESPONSE; HAMSTER; METABOLISM; PRECLINICAL STUDY; PROCEDURES;

ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NERVE TISSUE PROTEINS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84941560404     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2015.12     Document Type: Article

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