Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor

ACS Medicinal Chemistry Letters

Volumn 6, Issue 9, 2015, Pages 1015-1018

  Dvorak, Curt A ^a   Coate, Heather ^a   Nepomuceno, Diane ^a   Wennerholm, Michelle ^a   Kuei, Chester ^a   Lord, Brian ^a   Woody, David ^a   Bonaventure, Pascal ^a   Liu, Changlu ^a   Lovenberg, Timothy ^a   Carruthers, Nicholas I ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

agonists; glycine amides; GPR139; Orphan receptors

Indexed keywords

3 CHLORO N [2 OXO 2 ((1 PHENYLETHYL)AMINO)ETHYL]BENZAMIDE; BENZAMIDE DERIVATIVE; GLYCINE; UNCLASSIFIED DRUG;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN-TO-PLASMA RATIO; DRUG CLEARANCE; DRUG HALF LIFE; HIGH THROUGHPUT SCREENING; HYDROGEN BOND; MDCK CELL LINE; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; VOLUME OF DISTRIBUTION AT STEADY-STATE;

EID: 84941588312     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/acsmedchemlett.5b00247     Document Type: Article

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