Lipopolysaccharide Induces Chronic Kidney Injury and Fibrosis through Activation of mTOR Signaling in Macrophages

American Journal of Nephrology

Volumn 42, Issue 4, 2015, Pages 305-317

  Chen, Huihui ^a   Zhu, Jiefu ^a   Liu, Yu ^a   Dong, Zheng ^a,b   Liu, Hong ^a   Liu, Yinghong ^a   Zhou, Xiang ^a   Liu, Fuyou ^a   Chen, Guochun ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Endotoxemina; Inflammation; Kidney fibrosis; Macrophage; mTOR

Indexed keywords

COLLAGEN TYPE 1; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MAMMALIAN TARGET OF RAPAMYCIN; MONOCYTE CHEMOTACTIC PROTEIN 1; RAPAMYCIN; CCL2 PROTEIN, MOUSE; COLLAGEN; IL1B PROTEIN, MOUSE; IMMUNOSUPPRESSIVE AGENT; MESSENGER RNA; MTOR PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOTOXEMIA; ENZYME ACTIVATION; ENZYME INHIBITION; EX VIVO STUDY; FIBROSING ALVEOLITIS; INFLAMMATION; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY INTERSTITIUM; KIDNEY PROXIMAL TUBULE; KIDNEY TUBULE DAMAGE; MACROPHAGE; MACROPHAGE ACTIVATION; MALE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SEPSIS; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL LINE; COMPLICATION; DRUG EFFECTS; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; KIDNEY; KIDNEY TUBULE; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; RENAL INSUFFICIENCY, CHRONIC; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CHEMOKINE CCL2; COLLAGEN; ENDOTOXEMIA; FIBROSIS; FLUORESCENT ANTIBODY TECHNIQUE; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1BETA; KIDNEY; KIDNEY TUBULES; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; REAL-TIME POLYMERASE CHAIN REACTION; RENAL INSUFFICIENCY, CHRONIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES;

EID: 84946722363     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000441506     Document Type: Article

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