Macrophage/monocyte depletion by clodronate, but not diphtheria toxin, improves renal ischemia/reperfusion injury in mice

Kidney International

Volumn 82, Issue 8, 2012, Pages 928-933

  Ferenbach, David A ^a   Sheldrake, Tara A ^a   Dhaliwal, Kevin ^a   Kipari, Tiina M J ^a   Marson, Lorna P ^a   Kluth, David C ^a   Hughes, Jeremy ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CLODRONIC ACID; DIPHTHERIA TOXIN; GAMMA INTERFERON; GLYCOPROTEIN P 15095; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA;

ACUTE KIDNEY TUBULE NECROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL POPULATION; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE RELEASE; DEPLETION; DRUG POTENCY; KIDNEY FAILURE; KIDNEY ISCHEMIA; MACROPHAGE; MACROPHAGE DEPLETION; MALE; MONOCYTE DEPLETION; MONONUCLEAR PHAGOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; RENAL PROTECTION; REPERFUSION INJURY; TRANSGENIC MOUSE;

EID: 84867073684     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2012.207     Document Type: Article

References (25)

1. Kluth DC, Erwig LP, Rees AJ. Multiple facets of macrophages in renal injury. Kidney Int 2004; 66: 542-557.
2. Jo SK, Sung SA, Cho WY et al. Macrophages contribute to the initiation of ischaemic acute renal failure in rats. Nephrol Dial Transplant 2006; 21: 1231-1239.
3. Day YJ, Huang L, Ye H et al. Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages. Am J Physiol Renal Physiol 2005; 288: F722-F731.
4. Duffield JS, Forbes SJ, Constandinou CM et al. Selective depletion of macrophages reveals distinct, opposing roles during liver injury and repair. J Clin Invest 2005; 115: 56-65.
5. Devey L, Ferenbach D, Mohr E et al. Tissue-resident macrophages protect the liver from ischemia reperfusion injury via a heme oxygenase-1-dependent mechanism. Mol Ther 2009; 17: 65-72.
6. Duffield JS, Tipping PG, Kipari T et al. Conditional ablation of macrophages halts progression of crescentic glomerulonephritis. Am J Pathol 2005; 167: 1207-1219.
7. Henderson NC, Mackinnon AC, Farnworth SL et al. Galectin-3 expression and secretion links macrophages to the promotion of renal fibrosis. Am J Pathol 2008; 172: 288-298.
8. Qi F, Adair A, Ferenbach D et al. Depletion of cells of monocyte lineage prevents loss of renal microvasculature in murine kidney transplantation. Transplantation 2008; 86: 1267-1274.
9. Li L, Huang L, Sung SS et al. The chemokine receptors CCR2 and CX3CR1 mediate monocyte/macrophage trafficking in kidney ischemiareperfusion injury. Kidney Int 2008; 74: 1526-1537.
10. Ferenbach DA, Nkejabega NC, McKay J et al. The induction of macrophage hemeoxygenase-1 is protective during acute kidney injury in aging mice. Kidney Int 2011; 79: 966-976.
11. Savill J, Dransfield I, Gregory C et al. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol 2002; 2: 965-975.
12. Hume DA. Macrophages as APC and the dendritic cell myth. J Immunol 2008; 181: 5829-5835.
13. Scholz J, Lukacs-Kornek V, Engel DR et al. Renal dendritic cells stimulate IL-10 production and attenuate nephrotoxic nephritis. J Am Soc Nephrol 2008; 19: 527-537.
14. Tadagavadi RK, Reeves WB. Renal dendritic cells ameliorate nephrotoxic acute kidney injury. J Am Soc Nephrol 2010; 21: 53-63.
15. Machida Y, Kitamoto K, Izumi Y et al. Renal fibrosis in murine obstructive nephropathy is attenuated by depletion of monocyte lineage, not dendritic cells. J Pharmacol Sci 2010; 114: 464-473.
16. Li L, Okusa MD. Macrophages, dendritic cells, and kidney ischemiareperfusion injury. Semin Nephrol 2010; 30: 268-277.
17. Dong X, Swaminathan S, Bachman LA et al. Resident dendritic cells are the predominant TNF-secreting cell in early renal ischemia-reperfusion injury. Kidney Int 2007; 71: 619-628.
18. Lee S, Huen S, Nishio H et al. Distinct macrophage phenotypes contribute to kidney injury and repair. J Am Soc Nephrol 2011; 22: 317-326.
19. Tadagavadi RK, Reeves WB. Endogenous IL-10 attenuates cisplatin nephrotoxicity: role of dendritic cells. J Immunol 2010; 185: 4904-4911.
20. Lassen S, Lech M, Rommele C et al. Ischemia reperfusion induces IFN regulatory factor 4 in renal dendritic cells, which suppresses postischemic inflammation and prevents acute renal failure. J Immunol 2010; 185: 1976-1983.
21. Lech M, Avila-Ferrufino A, Allam R et al. Resident dendritic cells prevent postischemic acute renal failure by help of single Ig IL-1 receptor-related protein. J Immunol 2009; 183: 4109-4118.
22. Stuart LM, Lucas M, Simpson C et al. Inhibitory effects of apoptotic cell ingestion upon endotoxin-driven myeloid dendritic cell maturation. J Immunol 2002; 168: 1627-1635.
23. Chen Y, Khanna S, Goodyear CS et al. Regulation of dendritic cells and macrophages by an anti-apoptotic cell natural antibody that suppresses TLR responses and inhibits inflammatory arthritis. J Immunol 2009; 183: 1346-1359.
24. Amarilyo G, Verbovetski I, Atallah M et al. iC3b-opsonized apoptotic cells mediate a distinct anti-inflammatory response and transcriptional NF-kappaB-dependent blockade. Eur J Immunol 2010; 40: 699-709.
25. Van Rooijen N, Sanders A. Liposome mediated depletion of macrophages: mechanism of action, preparation of liposomes and applications. J Immunol Methods 1994; 174: 83-93.