HMGB1 exacerbates renal tubulointerstitial fibrosis through facilitating M1 macrophage phenotype at the early stage of obstructive injury

American Journal of Physiology - Renal Physiology

Volumn 308, Issue 1, 2015, Pages F69-F75

  Tian, Shaojiang ^a,b   Zhang, Lansing ^a   Tang, Junming ^a,b   Guo, Xia ^a   Dong, Kun ^a   Chen, Shi You ^a,b  

^a UNIVERSITY OF GEORGIA   (United States)

^b HUBEI UNIVERSITY OF MEDICINE   (China)

Author keywords

High mobility group box 1 protein; Macrophage; Phenotype; Renal fibrosis; Unilateral ureter obstruction

Indexed keywords

GLYCYRRHIZIC ACID DERIVATIVE; HIGH MOBILITY GROUP B1 PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 10; GLYCYRRHIZIC ACID; HMGB1 PROTEIN, MOUSE; PLANT EXTRACT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; EPITHELIUM CELL; IN VITRO STUDY; KIDNEY FIBROSIS; KIDNEY INJURY; KIDNEY INTERSTITIUM; KIDNEY TUBULE EPITHELIUM; MACROPHAGE; MALE; MOUSE; NONHUMAN; PH; PHENOTYPE; POLARIZATION; PROTEIN EXPRESSION; RENAL TUBULOINTERSTITIAL FIBROSIS; URETER OBSTRUCTION; URINE ACIDIFICATION; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL CULTURE; COMPLICATION; HUMAN; IMMUNOLOGY; METABOLISM; NEPHROSCLEROSIS; PHYSIOLOGY; PHYTOTHERAPY; PRECLINICAL STUDY; SECRETION (PROCESS); HISTOPATHOLOGY; KIDNEY PARENCHYMA; KIDNEY TUBULE CELL; MACROPHAGE ACTIVATION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SECRETION; PROTEIN URINE LEVEL; RENAL PROTECTION; UNILATERAL URETER OBSTRUCTION; URINE PH;

ANIMALS; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; GLYCYRRHIZIC ACID; HMGB1 PROTEIN; HUMANS; MACROPHAGES; MALE; MICE, INBRED C57BL; NEPHROSCLEROSIS; PHENOTYPE; PHYTOTHERAPY; PLANT EXTRACTS; URETERAL OBSTRUCTION;

EID: 84920280756     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00484.2014     Document Type: Article

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