Fluoxetine ameliorates cognitive impairments induced by chronic cerebral hypoperfusion via down-regulation of HCN2 surface expression in the hippocampal CA1 area in rats

Pharmacology Biochemistry and Behavior

Volumn 140, Issue , 2016, Pages 1-7

  Luo, Pan ^a   Zhang, Xiaoxue ^a   Lu, Yun ^a   Chen, Cheng ^a   Li, Changjun ^b   Zhou, Mei ^a   Lu, Qing ^a   Xu, Xulin ^a   Shen, Guanxin ^a   Guo, Lianjun ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Huanggang Central Hospital   (China)

Author keywords

Chronic cerebral hypoperfusion; Cognitive impairments; Fluoxetine; HCN2 subunit

Indexed keywords

FLUOXETINE; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL; HYPERPOLARIZATION ACTIVATED CYCLIC NUCLEOTIDE GATED CHANNEL 2; UNCLASSIFIED DRUG; HCN2 PROTEIN, RAT; POTASSIUM CHANNEL; SEROTONIN UPTAKE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN ISCHEMIA; CAROTID ARTERY OBSTRUCTION; CHRONIC CEREBRAL HYPOPERFUSION; COGNITION; COGNITIVE DEFECT; COMMON CAROTID ARTERY; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; HIPPOCAMPAL CA1 REGION; LONG TERM POTENTIATION; MALE; MORRIS WATER MAZE TEST; NEUROPROTECTION; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL NERVE CELL; RAT; SPATIAL LEARNING; SYNAPTIC TRANSMISSION; UPREGULATION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; BRAIN CIRCULATION; CAROTID STENOSIS; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; DRUG EFFECTS; GENETICS; LEARNING DISORDERS; MAZE TEST; MEMORY DISORDERS; METABOLISM; PATHOPHYSIOLOGY; RECOGNITION; SPRAGUE DAWLEY RAT; SYNAPSE; VASCULARIZATION;

ANIMALS; CA1 REGION, HIPPOCAMPAL; CAROTID STENOSIS; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; COGNITION DISORDERS; DOWN-REGULATION; FLUOXETINE; HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNELS; LEARNING DISORDERS; MALE; MAZE LEARNING; MEMORY DISORDERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RECOGNITION (PSYCHOLOGY); SEROTONIN UPTAKE INHIBITORS; SYNAPSES;

EID: 84946722281     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2015.11.003     Document Type: Article

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