Global ischemia and behavioural deficits

Progress in Neurobiology

Volumn 58, Issue 3, 1999, Pages 279-295

  Block, F ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; ASSOCIATION; BEHAVIOR DISORDER; BRAIN ISCHEMIA; COGNITIVE DEFECT; COMORBIDITY; DISEASE ASSOCIATION; FETAL TISSUE TRANSPLANTATION; MAZE TEST; NONHUMAN; PRIORITY JOURNAL; TASK PERFORMANCE; TREATMENT OUTCOME;

EID: 0032947164     PISSN: 03010082     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-0082(98)00085-9     Document Type: Review

References (162)

1. Alexander M. P. Specific semantic memory loss after hypoxic-ischemic injury. Neurology. 48:1997;165-173.
2. Alps B. J., Calder C., Hass W. K., Wilson A. D. Comparative protective effects of nicardipine, flunarizine, lidoflazine and nimodipine against ischemic injury in the hippocampus of the Mongolian gerbil. Br. J. Pharmacol. 93:1988;877-883.
3. Araki H., Nojiri M., Kawashima K., Kimura M., Aihara H. Behavioral, electroencephalographic and histopathological studies on Mongolian gerbils with occluded common carotid arteries. Physiol. Behav. 38:1986;89-94.
4. Araki T., Kato H., Kogure K., Kanai Y. Long-term changes in gerbil brain neurotransmitter receptors following transient cerebral ischemia. Br. J. Pharmacol. 107:1992;437-442.
5. Auer R. N., Jensen M. L., Wishaw I. Q. Neurobehavioural deficit due to ischemic brain damage limited to half of the CA1 sector of the hippocampus. J. Neurosci. 9:1989;1641-1647.
6. Babcock A. M., Baker D. A., Hallock N. L., Lovec W. C., Lynch W. C., Peccia J. C. Neurotensin-induced hypothermia prevents hippocampal neuronal damage and increased locomotor activity in ischemic gerbils. Brain Res. Bull. 32:1993;373-378.
7. Basseti C., Bomio F., Mathis J., Hess C. W. Early prognosis in coma after cardiac arrest: a prospective clinical, electrophysiological, and biochemical study of 60 patients. J. Neurol. Neurosurg. Psychiat. 61:1996;610-615.
8. Benfenati F., Pich E. M., Grimaldi R., Zoli M., Fuxe K., Toffano G., Agnati L. F. Transient forebrain ischemia produces multiple deficits in dopamine D1 transmission in the lateral neostriatum of the rat. Brain Res. 498:1989;376-380.
9. Benveniste H., Drejer J., Schousboe A., Diemer N. H. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J. Neurochem. 43:1984;1369-1374.
10. Block F., Schwarz M. Memantine reduces functional and morphological consequences induced by global ischemia in rats. Neurosci. Lett. 208:1996;41-44.
11. Block F., Schwarz M. Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats. Brain Res. 741:1996;153-159.
12. Block F., Schwarz M. Correlation between hippocampal neuronal damage and spatial learning deficit due to global ischemia. Pharmacol. Biochem. Behav. 56:1997;755-761.
13. Block F., Schwarz M. Global ischemic neuronal damage relates to behavioural deficits: a pharmacological approach. Neuroscience. 82:1998;791-803.
14. Block F., Schwarz M. The b-wave of the electroretinogram as an index of retinal ischemia. Gen. Pharmac. 30:1998;281-287.
15. Block F., Jaspers R. M. A., Heim C., Sontag K.-H. S-emopamil ameliorates ischemic brain damage in rats: histological and behavioural approaches. Life Sci. 47:1990;1511-1518.
16. Block F., Schwarz M., Sontag K.-H. Retinal ischemia induced by occlusion of both common carotid arteries in rats as demonstrated by electroretinography. Neurosci. Lett. 144:1992;124-126.
17. Block F., Kunkel M., Schwarz M. Quinolinic acid lesion of the striatum induces impairment in spatial learning and motor performance in rats. Neurosci. Lett. 149:1993;126-128.
18. Block F., Kunkel M., Sontag K.-H. Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in rats. Brain Res. Bull. 36:1995;257-260.
19. Block F., Schmitt W., Schwarz M. The antioxidant LY 231617 ameliorates functional and morphological sequelae induced by global ischemia in rats. Brain Res. 694:1995;308-311.
20. Block F., Schmitt W., Schwarz M. Pretreatment but not posttreatment with GYKI 52466 reduces functional deficits and neuronal damage after global ischemia in rats. J. Neurol. Sci. 139:1996;167-172.
21. Block F., Pergande G., Schwarz M. Flupirtine reduces functional and neuronal damage after global ischemia in rats. Brain Res. 754:1997;279-284.
22. Block F., Tondar A., Schmidt W., Schwarz M. Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats. NeuroReport. 8:1997;3829-3832.
23. Bokura H., Robinson R. G. Long-term cognitive impairment associated with caudate stroke. Stroke. 28:1997;970-975.
24. Bradvik B., Sonesson B., Holtas S. Spatial impairment following right hemisphere transient ischaemic attacks in patients without carotid artery stenosis. Acta Neurol. Scand. 80:1989;411-418.
25. Brain Resuscitation Clinical Trial II Study Group Brain Resuscitation Clinical Trial II Study Group, A randomized clinical study of a calcium-entry blocker (lidoflazine) in the treatment of comatose survivors of cardiac arrest. N. Engl. J. Med. 324:1991;1225-1231.
26. Buszaki G., Freund T. F., Bayardo F., Somogyi P. Ischemia-induced changes in the electrical activity of the hippocampus. Exp. Brain Res. 78:1989;268-278.
27. Cao X., Phillis J. W. The free radical scavenger, aplha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils. Free Radic. Res. 23:1995;365-370.
28. Capdeville C., Pruneau O., Allix M., Plotkine M., Baulu R. G. Model of global forebrain ischemia in the unanesthetized rat. J. Pharmacol. 17:1986;553-560.
29. Carney, J. M., Tatsuno, T. and Floyd, R. A. (1992) The role of oxygen radicals in ischemic brain damage: free radical production, protein oxidation and tissue dysfunction. In: Pharmacology of Cerebral Ischemia, pp. 321-331. Eds J. Krieglstein and H. Oberpichler-Schwenk. Wissenschaftliche Verlagsgesellschaft, Stuttgart.
30. Chandler M. J., DeLeo J., Carney J. M. An unanesthetized gerbil model of cerebral ischemia-induced behavioural changes. J. Pharmacol. Meth. 14:1985;137-146.
31. Chang H. S., Sasaki T., Kassell N. F. Hippocampal unit activity after transient cerebral ischemia in rats. Stroke. 20:1989;1051-1058.
32. Chesselet M. F., Gonzales C., Lin C. S., Polsky K., Jin B. K. Ischemic damage in the striatum of adult gerbils: relative sparing of somatostatinergic and cholinergic interneurons contrasts with loss of efferent neurons. Exp. Neurol. 110:1990;209-218.
33. Clark W. M., Lauten J. D., Lessov N., Woodward W., Coull B. M. Time course of ICAM-1 expression and leukocyte subset infiltration in rat forebrain ischemia. Mol. Chem. Neuropathol. 26:1995;213-230.
34. Clough-Helfmann C., Phillis J. W. 5-Aminoimidazole-4-carboxamide riboside (AICAr) administration reduces cerebral ischemic damage in the Mongolian gerbil. Brain Res. Bull. 25:1990;203-206.
35. Colbourne F., Corbett D. Delayed postischemic hypothermia: a six month survival study using behavioral and histological assessments of neuroprotection. J. Neurosci. 15:1995;7250-7260.
36. Coimbra C., Drake M., Boris-Möller F., Wieloch T. Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug. Stroke. 27:1996;1578-1585.
37. Combs D. J., D'Alecy L. G. Motor performance in rats exposed to severe forebrain ischemia: effect of fasting and 1,3-butanediol. Stroke. 18:1987;503-511.
38. Corbett D., Evans S. J., Nurse S. M. Impaired acquisition of the Morris water maze following global ischemic damage in the gerbil. NeuroReport. 3:1992;204-206.
39. Cummings J. L., Tomiyasu S., Read S., Benson D. F. Amnesia with hippocampal lesions after cardiopulmonary arrest. Neurology. 34:1984;679-681.
40. Davis H. P., Tribuna J., Pulsinelli W. A., Volpe B. T. Reference and working memory of rats following hippocampal damage induced by transient forebrain ischemia. Physiol. Behav. 37:1986;387-392.
41. Del Zoppo G., Wagner S., Tagaya M. Trends and future development in the pharmacological treatment of acute ischaemic stroke. Drugs. 54:1997;9-38.
42. Dietrich W. D., Busto R., Alonso O., Globus M.Y-T., Ginsberg M. D. Intra-ischemic but not post-ischemic hypothermia protects chronically following global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 13:1993;541-549.
43. Duhaime A.-C., Ross D. T. Degeneration of hippocampal CA1 neurons following transient ischemia due to raised intracranial pressure: evidence for a temperature-dependent excitotoxic process. Brain Res. 512:1990;169-174.
44. Endoh M., Maiese K., Wagner J. Expression of inducible form of nitric oxide synthase by reactive astrocytes after transient global ischemia. Brain Res. 651:1994;92-100.
45. Fix A. S., Horn J. W., Wightman K. A., Johnson C. A., Long G. G., Storts R. W., Farber N., Wozniak D. F., Olney J. W. Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex. Exp. Neurol. 123:1993;204-215.
46. Gallyas F., Hsu M., Buzsaki G. Delayed degeneration of the optic tract and neurons in the superior colliculus after forebrain ischemia. Neurosci. Lett. 144:1992;177-179.
47. Gehrmann J., Bonnekoh P., Miyazawa T., Hossmann K.-A., Kreutzberg G. W. Immunocytochemical study of an early microglial activation in ischemia. J. Cereb. Blood Flow Metab. 12:1992;257-269.
48. Gerhardt S. C., Boast C. A. Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus. Behav. Neurosci. 102:1988;301-303.
49. Ginsberg M. D. The validity of rodent brain-ischemia models is self-evident. Arch. Neurol. 53:1996;1065-1070.
50. Ginsberg M. D., Busto R. Rodent models of cerebral ischemia. Stroke. 20:1989;1627-1642.
51. Gionet T. X., Thomas J. D., Warner D. S., Goodlett C. R., Wassermann E. A., West J. R. Forebrain ischemia induces selective behavioral impairments associated with hippocampal injury in rats. Stroke. 22:1991;1040-1047.
52. Globus M. Y.-T., Busto R., Martinez E., Valdes I., Dietrich W. D., Ginsberg M. D. Comparative effect of transient global ischemia on extracellular levels of glutamate, glycine, and γ-aminobutyric acid in vulnerable and nonvulnerable brain regions in the rat. J. Neurochem. 57:1991;470-478.
53. Godefroy O., Rousseaux M., Pruvo J. P., Cabaret M., Leys D. Neuropsychological changes related to unilateral lenticostriate infarcts. J. Neurol. Neurosurg. Psychiat. 57:1994;480-485.
54. Goto K., Ishige A., Sekiguchi K., Izuka S., Sugimoto A., Yuzurihara M., Aburada M., Hosoya E., Kogure K. Effects of cycloheximide on delayed neuronal death in rat hippocampus. Brain Res. 534:1990;299-302.
55. Green E. J., Dietrich W. D., van Dijk F., Busto R., Markgraf C. G., McGabe P. M., Ginsberg M. D., Schneidermann N. Protective effects of brain hypothermia on behavior and histopathology following global ischemia in rats. Brain Res. 580:1992;197-204.
56. Green E. J., Pazos A. J., Dietrich W. D., McGabe P. M., Schneidermann N., Lin B., Busto R., Globus M. Y.-T., Ginsberg M. D. Combined postischemic hypothermia and delayed MK-801 treatment attenuates neurobehavioral deficits associated with transient global ischemia in rats. Brain Res. 702:1995;145-152.
57. Grieco G., d'Hollosy M., Culliford A. T., Jonas S. Evaluating neuroprotective agents for clinical anti-ischemic benefit using neurological and neuropsychological changes after cardiac surgery under cardiopulmonary bypass. Stroke. 27:1996;858-874.
58. Grotta J. The current status of neuronal protective therapy: why have all neuronal protective drugs worked in animals but none so far in stroke patients. Cerebrovasc. Dis. 4:1994;115-120.
59. Grotta J. C., Pettigrew L. C., Rosenbaum D., Reid C., Rhoades H., McCandless D. Efficacy and mechanism of action of a calcium channel blocker after global cerebral ischemia in rats. Stroke. 19:1988;447-454.
60. Hagan J. J., Beaughard M. The effects of forebrain ischaemia on spatial learning. Behav. Brain Res. 41:1990;151-160.
61. Hara H., Kato H., Kogure K. Protective effect of α-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res. 510:1990;335-338.
62. Hara H., Onodera H., Yoshidomi M., Matsuda Y., Kogure K. Staurosporine, a novel protein kinase C inhibitor, prevents postischemic neuronal damage in the gerbil and rat. J. Cereb. Blood Flow Metab. 10:1990;646-653.
63. 2+ accumulation in cortical cell culture correlates with subsequent neuronal degeneration J. Neurosci. 13:1993;1993-2000.
64. Heinrich-Noack P., Prehn J. H. M., Krieglstein J. TGF-β1 protects hippocampal neurons against degeneration caused by transient global ischemia. Stroke. 27:1996;1609-1615.
65. Hodges H., Sowinski P., Fleming P., Kershaw T. R., Sinden J. D., Meldrum B. S., Gray J. A. Contrasting effects of fetal CA1 and CA3 hippocampal grafts on deficits in spatial learning and working memory induced by global cerebral ischaemia in rats. Neuroscience. 72:1996;959-988.
66. Hunter A. J., Green A. R., Cross A. J. Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs? Trends Pharmacol. Sci. 16:1995;123-128.
67. Jan M., Buchheit F., Tremoulet M. Therapeutic trial of inravenous nimodipine in patients with established cerebral vasospasm after rupture of intracranial aneurysms. Neurosurgery. 23:1988;154-157.
68. Jaspers R. M. A., Block F., Heim C., Sontag K.-H. Spatial learning is affected by transient occlusion of common carotid arteries (2VO): comparison of behavioural and histopathological changes after '2VO' and 'four-vessel-occlusion' in rats. Neurosci. Lett. 117:1990;149-153.
69. Johansen F. F., Zimmer J., Diemer N. H. Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat preceds CA-1 pyramidal cell loss. Acta Neuropathol. 73:1987;110-114.
70. Judge M. E., Sheardown M. J., Jacobsen P., Honore T. Protection against post-ischemic pathology by the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo(f)quinoxaline (NBQX) in the gerbil. Neurosci. Lett. 133:1991;291-294.
71. Katoh A., Ishibashi C., Shiomi T., Takahara Y., Eigyo M. Ischemia-induced irreversible deficit of memory function in gerbils. Brain Res. 577:1992;57-63.
72. Karasawa Y., Araki H., Otomo S. Changes in locomotor activity and passive avoidance task performance induced by cerebral ischemia in mongolian gerbils. Stroke. 25:1994;645-650.
73. Kawai K., Niteka L., Ruetzler C. A., Nagashima G., Joo F., Mies G., Nowak T. S., Saito N., Lohr J. M., Klatzo I. Global cerebral ischemia associated with cardiac arrest in the rat: I. Dynamics of early neuronal changes. J. Cereb. Blood Flow Metab. 12:1992;238-249.
74. Kihara S., Shiraishi T., Nakagawa S., Toda K., Tabuchi K. Visualization of DNA double strand breaks in the gerbil hippocampal CA1 following transient ischemia. Neurosci. Lett. 175:1994;133-136.
75. Kirino T. Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res. 239:1982;57-69.
76. Kiyota Y., Miyamoto M., Nagaoka A. Relationship between brain damage and memory impairment in rats exposed to transient forebrain ischemia. Brain Res. 538:1991;295-302.
77. Kohno K., Ohta S., Kumon Y., Mitani A., Sakaki S., Kataoka K. Nitric oxide synthase inhibitor reduces delayed neuronal death in gerbil hippocampal CA1 neurons after transient global ischemia without reduction of brain temperature or extracellular glutamate concentration. Brain Res. 738:1996;275-280.
78. Kozuka M., Kobayashi K., Iwata N. Changes in glucose utilization in the rat brain after transient forebrain ischemia. Stroke. 24:1993;1568-1575.
79. Kristian T., Siesjö B. K. Calcium in ischemic cell death. Stroke. 29:1998;705-718.
80. Kuroiwa T., Bonnekoh P., Hossmann K.-A. Locomotor hyperactivity and hippocampal CA1 injury after transient forebrain ischemia of gerbils. Neurosci. Lett. 122:1991;141-144.
81. LePeillet E., Arvin B., Moncada C., Meldrum B. S. The non-NMDA antagonists, NBQX and GYKI 52466, protect against cortical and striatal cell loss following transient global ischemia in the rat. Brain Res. 571:1992;115-120.
82. Li H., Buchan A. M. Progressive loss of hippocampal CA1 neurons following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 15(Suppl. 1):1995;S246.
83. Lin B., Dietrich W. D., Busto R., Ginsberg M. D. S-emopamil protects against global ischemic brain injury in rats. Stroke. 21:1990;1734-1739.
84. Loeb C., Meyer J. S. Vascular dementia: still a debatable entity? J. Neurol. Sci. 143:1996;31-40.
85. von Lubitz D. K. J. E., Beenhakker M., Lin R., Carter M. F., Paul I. A., Bischofberger N., Jacobson K. A. Reduction of postischemic brain damage and memory deficits following selective adenosine A1 receptor agonist. Eur. J. Pharmacol. 302:1996;43-48.
86. von Lubitz D. K. J. E., Lin R. C., Paul I. A., Beenhakker M., Boyd M., Bischofberger N., Jacobson K. A. Postischemic administration of adenosine amine congener (ADAC): analysis of recovery in gerbils. Eur. J. Pharmacol. 316:1996;171-179.
87. Malgouris C., Bardot F., Daniel M., Pellis F., Rataud J., Uzan A., Blanchard J.-C., Laduron P. M. Riluzuole, a novel antiglutamate, prevents memory loss and hippocampal neuronal damage in ischemic gerbils. J. Neurosci. 9:1989;3720-3727.
88. Masada T., Itano T., Fujisawa M., Miyamoto O., Tokuda M., Matsui H., Nagao S., Hatase O. Embryonic transplantation and ischemic memory deficit. Neurosci. Res. 27:1997;249-255.
89. Matsuda S., Wen T-C., Morita F., Otsuka H., Igase K., Yoshimura H., Sakanaka M. Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils. Neurosci. Lett. 204:1996;109-112.
90. Mileson B. E., Schwartz R. D. The use of locomotor activity as a behavioral screen for neuronal damage following transient forebrain ischemia in gerbils. Neurosci. Lett. 128:1991;71-76.
91. Mitani A., Imon H., Kataoka K. High-frequency discharge of gerbil hippocampal neurons shortly after ischemia. Brain Res. Bull. 23:1989;569-572.
92. Morioka T., Kalehua A. N., Streit W. J. Progressive expression of immunomolecules on microglial cells in rat dorsal hippocampus following transient forebrain ischemia. Acta Neuropathol. 83:1992;149-157.
93. Morris R. G. M. Development of a water-maze procedure for studying spatial learning in the rat. J. Neurosci. Meth. 11:1984;47-60.
94. Morris R. G. M., Garrud P., Rawlins J. N. P., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature. 297:1982;681-683.
95. Morris R. G. M., Anderson E., Lynch G. S., Baudry M. Selective blockade of learning and blockade of long-term potentiation by an N-methyl-D-aspartate antagonist, AP5. Nature. 319:1986;774-776.
96. Moser E., Moser M.-B., Andersen P. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions, but is hardly present following ventral lesions. J. Neurosci. 13:1993;3916-3925.
97. Nakanishi H., Katsuta K., Koide T., Ueda Y., Shirakawa K., Yoshida K. Protective effect of FR115427 against ischemic hippocampal damage in gerbils. Jpn. J. Pharmacol. 64:1994;189-193.
98. Nakata N., Kato H., Kogure K. Protective effect of basic fibroblast growth factor against hippocampal neuronal damage following cerebral ischemia in the gerbil. Brain Res. 605:1993;354-356.
99. Nelson A., Lebessi A., Sowinski P., Hodges H. Comparison of effects of global ischemia on spatial learning in the standard and radial water maze: relationship of hippocampal damage to performance. Behav. Brain Res. 85:1997;93-116.
100. Netto C. A., Hodges H., Sinden J. D., LePeillet E., Kershaw T., Sowinski P., Meldrum B. S., Gray J. A. Effects of foetal hippocampal grafts on ischemic-induced deficits in spatial navigation in the water maze. Neuroscience. 54:1993;69-92.
101. Nitatori T., Sato N., Waguri S., Karasawa Y., Araki H., Shibanai K., Kominami E., Uchiyama Y. Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis. J. Neurosci. 15:1995;1001-1011.
102. Nunn, J.A. (1993) Cerebral ischemia: hippocampal pathology and spatial deficits in the rat. PhD Thesis, Faculty of Science, London University, London.
103. Nunn J. A., Jarrad L. E. Silver impregnation reveals neuronal damage in cingulate cortex following 4VO ischaemia in the rat. NeuroReport. 5:1994;2363-2366.
104. Nunn J. A., LePeillet E., Netto C. A., Hodges H., Gray J. A., Meldrum B. S. Global ischemia: hippocampal pathology and spatial deficits in the water maze. Behav. Brain Res. 62:1994;41-54.
105. Nurse S., Corbett D. Direct measurement of brain temperature during and after intraischemic hypothermia: correlation with behavioural, physiological, and histological endpoints. J. Neurosci. 14:1994;7726-7734.
106. Ohno M., Yamamoto T., Watanabe S. Effect of staurosporine, a protein kinase C inhibitor, on impairment of working memory in rats exposed to cerebral ischemia. Eur. J. Pharmacol. 204:1991;113-116.
107. Olsen G. M., Scheel-Krüger J., Moller A., Jensen L. H. Does neuronal damage of CA1 relate to spatial memory performance of rats subjected to transient forebrain ischemia? Acta Neurol. Scand. 89:1994;204-209.
108. Olsen G. M., Scheel-Krüger J., Moller A., Jensen L. H. Relation of spatial learning of rats in the Morris water maze task to the number of viable CA1 neurons following four-vessel occlusion. Behav. Neurosci. 108:1994;681-690.
109. Onifer, S. M. and Low, W. C. (1990) Spatial memory deficit resulting from ischemia-induced damage to the hippocampus is ameliorated by intra-hippocampal transplants of fetal hippocampal neurons. In: Progress in Brain Research, Vol. 82, pp. 359-366. Eds S. B. Dunnett and S.-J. Richards. Elsevier Science, Amsterdam.
110. Osborne N. N., Block F., Sontag K.-H. Reduction in ocular blood flow results in GFAP expression in rat retinal Müller cells. Vis. Neurosci. 7:1991;637-639.
111. Owen A. J., Ijaz S., Miyashita H., Wishart T., Howlett W., Shuaib A. Zonisamide as a neuroprotective agent in an adult gerbil model of global forebrain ischemia: a histological, in vivo microdialysis and behavioral study. Brain Res. 770:1997;115-122.
112. Pellegrini-Giampetro D. E., Zukin R. S., Bennett M. V. L., Cho S., Pulsinelli W. A. Switch in glutamate receptor subunit gene expression in CA1 subfield of hippocampus following global ischemia in rats. Proc. Natl Acad. Sci. USA. 89:1992;10499-10503.
113. Peterson B., Summergrad P. Binswanger's disease (Part II): pathogenesis of subcortical arteriosclerotic encephalopathy and its relation to other dementing processes. J. Geriatr. Psychiatry Neurol. 2:1989;171-181.
114. Petito C. K., Morgello S., Felix J. C., Lesser M. L. The two patterns of reactive astrocytosis in postischemic rat brain. J. Cereb. Blood Flow Metab. 10:1990;850-859.
115. Petito C. K., Olarte J. P., Roberts B., Nowak T. S., Pulsinelli W. A. Selective glial vulnerability following transient global ischemia in rat brain. J. Neuropathol. Exp. Neurol. 57:1998;231-238.
116. Phillis J. W. Oyxpurinol attenuates ischemia-induced hippocampal damage in the gerbil. Brain Res. Bull. 23:1989;467-470.
117. Pickard J. D., Murray G. D., Illingworth R., Shaw M. D. M., Teasdale G. M., Foy P. M., Humphrey P. R. D., Lang D. A., Nelson R., Richards S., Sinar J., Bailey S., Skene A. Effect of nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. Br. J. Med. 298:1989;636-642.
118. Poignet H., Beaughard M., Lecoin G., Massingham R. Functional, behavioral, and histological changes induced by transient global cerebral ischemia in rats: effects of cinnarizine and flunarizine. J. Cereb. Blood Flow Metab. 9:1989;646-654.
119. Pulsinelli W. A., Brierley J. B., Plum F. Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann. Neurol. 11:1982;491-498.
120. Pulsinelli W. A., Levy D. E., Duffy T. E. Regional cerebral blood flow and glucose metabolism following transient forebrain ischemia. Ann. Neurol. 11:1982;499-509.
121. Rempel-Clower N. L., Zola S. M., Squire L. R., Amaral D. G. Three cases of enduring memory impairment after bilateral damage limited to the hippocampal formation. J. Neurosci. 16:1996;5233-5255.
122. van Rijen P. C., Verheul H. B., van Echteld C. J., Balazs R., Lewis P., Nasim M. M., Tulleken C. A. Effects of dextromethorphan on rat brain during ischemia and reperfusion assessed by magnetic resonance spectroscopy. Stroke. 22:1991;343-350.
123. Rod M. R., Wishaw I. Q., Auer R. N. The relationship of structural ischemic brain damage to neurobehavioural deficit: the effect of postischemic MK-801. Can. J. Psychol. 44:1990;196-209.
124. Roine R. O., Raininko R., Erkinjuntti T., Ylikoski A., Kaste M. Magnetic resonance findings associated with cardiac arrest. Stroke. 24:1993;1005-1014.
125. Rudolphi K. A., Schubert P., Parkinson F. E., Fredholm B. B. Adenosine and brain ischemia. Cerebovasc. Brain Metab. Rev. 4:1992;346-369.
126. Sairanen T. R., Lindsberg P. J., Brenner M., Siren A.-L. Global forebrain ischemia results in differential cellular expression of interleukin-1β (IL-1β) and its receptor at mRNA and protein level. J. Cereb. Blood Flow Metab. 17:1997;107-120.
127. Saito K., Suyama K., Nishida K., Sei Y., Basile A. Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain. Neurosci. Lett. 206:1996;149-152.
128. 2+ homeostasis in the gerbil hippocampus following brief transient ischemia. Brain Res. 364:1986;372-376.
129. Sato P. H., Hall E. D. Tirilazad protects vitamins C and E in brain ischemia-reperfusion injury. J. Neurochem. 58:1992;2263-2268.
130. Schmidt-Kastner R., Hossmann K.-A. Distribution of ischemic neuronal damage in the dorsal hippocampus of the rat. Acta Neuropathol. 76:1988;411-421.
131. Schmidt-Kastner R., Paschen W., Grosse Ophoff B., Hossmann K.-A. A modified four-vessel occlusion model for inducing incomplete forebrain ischemia in rats. Stroke. 20:1989;938-946.
132. Schmidt-Kastner R., Szymas J., Hossmann K.-A. Immunohistochemical study of glial reaction and serum-protein extravasation in relation to neuronal damage in rat hippocampus after ischemia. Neuroscience. 38:1990;527-540.
133. Schwarz, M. and Block, F. Contribution of striatal damage to learning impairment and motor deficits following global ischemia in rats. Brain Res. in press.
134. Shaw P. J., Bates D., Cartligde N. E. F., French J. M., Heaviside D., Julian D. G., Shaw D. A. Neurologic and neuropsychological morbidity following major surgery: comparison of coronary artery bypass and peripheral vascular surgery. Stroke. 18:1987;700-707.
135. Shuaib A., Mahmood R. H., Wishart T., Kanthan R., Murabit M. A., Ijaz S., Miyashita H., Howlett W. Neuroprotective effects of lamotrigine in global ischemia in gerbils. A histological, in vivo microdialysis and behavioral study. Brain Res. 702:1995;199-206.
136. Shuaib A., Murabit M. A., Kanthan R., Howlett W., Wishart T. The neuroprotective effects of gamma-vinyl GABA in transient global ischemia: a morphological study with early and delayed evaluations. Neurosci. Lett. 204:1996;1-4.
137. Shuaib A., Waqaar T., Ijaz M. S., Kanthan R., Wishart T., Howlett W. Neuroprotection with felbamate: a 7- and 28-day study in transient forebrain ischemia in gerbils. Brain Res. 727:1996;65-70.
138. Shuaib A., Waqar T., Wishart T., Kanthan R. Post-ischemic therapy with CGS-19755 (alone or in combination with hypothermia) in gerbils. Neurosci. Lett. 191:1995;87-90.
139. Siesjö B. K., Agadh C. D., Bengtsson F. Free radicals and brain damage. Brain Metab. Rev. 1:1989;165-211.
140. Sinden J. D., Rashid Doubell F., Kershaw T. R., Nelson A., Chadwick A., Jat P. S., Noble M. D., Hodges H., Gray J. A. Recovery of spatial learning by grafts of a conditionally immortalized neuroepithelial cell line into the ischemia-lesioned hippocampus. Neuroscience. 81:1997;599-608.
141. Smith M.-L., Auer R. N., Siesjö B. K. The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol. 64:1984;319-332.
142. Suzuki R., Yamaguchi T., Li C.-L., Klatzo I. The effect of 5-minute ischemia in mongolian gerbils: II. Changes of spontaneous neuronal activity in cerebral cortex and CA1 sector of hippocampus. Acta Neuropathol. 60:1983;217-222.
143. Svensson A., Carlsson M., Carlsson A. Crucial role of the accumbens nucleus in the neutrotransmitter interactions regulating motor control in mice. J. Neural Transm. [Gen. Sect.]. 101:1995;127-148.
144. Swan J. H., Meldrum B. S. Protection by NMDA antagonists against selective cell loss following transient ischemia. J. Cereb. Blood Flow Metab. 10:1990;343-351.
145. Tanaka K., Gotoh F., Gomi S., Takashima S., Mihara B. Autoradiographic analysis on second-messenger systems and local cerebral blood flow in ischemic gerbil brain. J. Cereb. Blood Flow Metab. 11:1991;283-291.
146. Tonder N., Sorenson T., Zimmer J., Jorgenson M. B., Johanson F. F., Diemer N. H. Neural grafting to ischemic lesions of the adult rat hippocampus. Exp. Brain Res. 74:1989;512-526.
147. Uno H., Matsuyama T., Akita H., Nishimura H., Sugita M. Induction of tumor necrosis factor-α in the mouse hippocampus following transient forebrain ischemia. J. Cereb. Blood Flow Metab. 17:1997;491-499.
148. Valtysson J., Hillered L., Andine P., Hagberg H., Persson L. Neuropathological endpoints in experimental stroke pharmacotherapy: the importance of both early and late evaluation. Acta Neurochir. 129:1994;58-63.
149. Voll C. L., Auer R. N. The effect of post-ischemic blood glucose level on ischemic brain damage in the rat. Ann. Neurol. 24:1988;638-646.
150. Voll C. L., Wishaw I. Q., Auer R. N. Postischemic insulin reduces spatial learning deficit following transient forebrain ischemia in rats. Stroke. 20:1989;646-651.
151. Volpe B. T., Davis H. P., Colombo P. J. Preoperative training modifies radial maze performance in rats with ischemic hippocampal injury. Stroke. 20:1989;1700-1706.
152. Wang D., Corbett D. Cerebral ischemia, locomotor activity and spatial mapping. Brain Res. 533:1990;78-82.
153. Wahlgren N. G. Neuroprotectants in late clinical development - a status report. Cerebrovasc. Dis. 7(Suppl. 2):1997;13-17.
154. Wen T. C., Matsuda S., Yoshimura H., Aburaya J., Kushihata F., Sakanaka M. Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils. Neuroscience. 65:1995;513-521.
155. Wen T. C., Matsuda S., Yoshimura H., Kawabe T., Sakanaka M. Ciliary neurotrophic factor prevents ischemia-induced learning disability and neuronal loss in gerbils. Neurosci. Lett. 191:1995;55-58.
156. Wiard R. P., Dickerson M. C., Beek O., Norton R., Cooper B. R. Neuroprotective properties of the novel antiepileptic lamotrigine in a gerbil model of global cerebral ischemia. Stroke. 26:1995;466-472.
157. Wishaw I. Q., Mittelmann G., Bunch S. T., Dunnett S. B. Impairments in the acquisition, retention and selection of spatial navigation strategies after medial caudate-putamen lesions in rats. Behav. Brain Res. 24:1987;125-138.
158. Wishart T. B., Ijaz S., Shuaib A. Differential effects of amphetamine and haloperidol on recovery after global forebrain ischemia. Pharmacol. Biochem. Behav. 47:1994;963-968.
159. Wright J. W., Clemens J. A., Panetta J. A., Smalstig E. B., Weatherly L. S., Kramar E. A., Pederson E. S., Mungall B. H., Harding J. W. Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats. Brain Res. 717:1996;1-11.
160. Xue D., Huang Z.-G., Barnes K., Lesiuk H. J., Smith K. E., Buchan A. M. Delayed treatment with AMPA, but not with NMDA, antagonists reduces neocortical infarction. J. Cereb. Blood Flow Metab. 14:1994;251-261.
161. Zola-Morgan S., Squire L. R. Memory impairment in monkeys following lesions limited to the hippocampus. Behav. Neurosci. 100:1986;155-160.
162. Zola-Morgan S., Squire L. R., Amaral D. G. Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus. J. Neurosci. 6:1986;2950-2967.