Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria

eLife

Volumn 4, Issue September2015, 2015, Pages

  McCormack, Ryan M ^a   de Armas, Lesley R ^a   Shiratsuchi, Motoaki ^a   Fiorentino, Desiree G ^a   Olsson, Melissa L ^a   Lichtenheld, Mathias G ^a   Morales, Alejo ^a   Lyapichev, Kirill ^a   Gonzalez, Louis E ^a   Strbo, Natasa ^a   Sukumar, Neelima ^b   Stojadinovic, Olivera ^a   Plano, Gregory V ^a   Munson, George P ^a   Tomic Canic, Marjana ^a   Kirsner, Robert S ^a   Russell, David G ^b   Podack, Eckhard R ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b Cornell University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PERFORIN; PERFORIN 2; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; PORE FORMING CYTOTOXIC PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL LOAD; BACTERICIDAL ACTIVITY; CELL FRACTIONATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PARENCHYMA CELL; PHAGOCYTE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; SPECTROPHOTOMETRY; SURVIVAL; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING; ANIMAL; ANIMAL SALMONELLOSIS; CELL CULTURE; CELL VACUOLE; DISEASE MODEL; DRUG EFFECTS; IMMUNOLOGY; INNATE IMMUNITY; KNOCKOUT MOUSE; METABOLISM; MICROBIAL VIABILITY; MICROBIOLOGY; PHYSIOLOGY; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; SURVIVAL ANALYSIS;

ANIMALS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; MICE, KNOCKOUT; MICROBIAL VIABILITY; PHAGOCYTES; PORE FORMING CYTOTOXIC PROTEINS; SALMONELLA INFECTIONS, ANIMAL; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SURVIVAL ANALYSIS; VACUOLES;

EID: 84946593200     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.06508     Document Type: Article

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