Systemic dissemination and cutaneous damage in a mouse model of staphylococcal skin infections

Microbial Pathogenesis

Volumn 47, Issue 1, 2009, Pages 16-23

  Hahn, Beth L ^a,b   Onunkwo, Charles C ^a,b   Watts, Christopher J ^a,b   Sohnle, Peter G ^a,b  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

^b CLEMENT J ZABLOCKI VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL SKIN DISEASE; CONTROLLED STUDY; DERMIS; DISEASE COURSE; EPIDERMIS; KERATINOCYTE; KIDNEY INFECTION; LEUKOPENIA; MICROBIAL ACTIVITY; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; SKIN DEFECT; SKIN NECROSIS; SPLEEN DISEASE; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; SYSTEMIC DISEASE;

ANIMALS; BACTEREMIA; COLONY COUNT, MICROBIAL; FEMALE; KIDNEY; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; SPLEEN; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS AUREUS; TIME FACTORS;

ANIMALIA; MUS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 67349152679     PISSN: 08824010     EISSN: 10961208     Source Type: Journal    
DOI: 10.1016/j.micpath.2009.04.007     Document Type: Article

References (35)

1. Fridkin S.K., Hageman J.C., Morrison M., Sanza L.T., Como-Sabetti K., Jernigan J.A., et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med (2005) 1436-1444
2. Miller L.G., Perdreau-Remington F., Rieg G., Mehdi S., Perlroth J., Bayer A.S., et al. Necrotizing fasciitis caused by community-acquired methicillin-resistant Staphylococcus aureus in Los Angeles. N Engl J Med 352 (2005) 1445-1453
3. von Eiff C., Becker K., Machka K., Stammer H., and Peters G. Nasal carriage as a source of Staphylococcus aureus bacteremia. N Engl J Med 344 (2001) 11-16
4. Abe Y., Akiyama H., and Arata J. Furuncle-like lesions in mouse experimental skin infections with Staphylococcus aureus. J Dermatol 20 (1993) 198-202
5. Akiyama H., Kanzaki H., Tada J., and Arata J. Staphylococcus aureus infection on cut wounds in the mouse skin - experimental staphylococcal botryomycosis. J Dermatol Sci 11 (1996) 234-238
6. Akiyama H., Huh W.K., Yamasaki O., Oono T., and Iwatsuki K. Confocal laser scanning microscopic observation of glycocalyx production by Staphylococcus aureus in mouse skin - does S. aureus generally produce a biofilm on damaged skin?. Br J Dermatol 147 (2002) 879-885
7. Kugelberg E., Norstrom T., Petersen T.K., Duvold T., Andersson D.I., and Hughes D. Establishment of a superficial skin infection model in mice by using Staphylococcus aureus and Streptococcus pyogenes. Antimicrob Agents Chemother 49 (2005) 3435-3441
8. Singh G., Marples R.R., and Kligman A.M. Experimental Staphylococcus aureus infections in humans. J Invest Dermatol 57 (1971) 149-162
9. Molne L., and Tarkowski A. An experimental model of cutaneous infection induced by superantigen-producing Staphylococcus aureus. J Invest Dermatol 114 (2000) 1120-1125
10. Molne L., Verdrengh M., and Tarkowski A. Role of neutrophil leukocytes in cutaneous infection caused by Staphylococcus aureus. Infect Immun 68 (2000) 6162-6167
11. Kraft W.G., Johnson P.T., David B.C., and Morgan D. Cutaneous infection in normal and immunocompromised mice. Infect Immun 32 (1986) 707-713
12. Iwatsuki K., Yamasaki O., Morizane S., and Oono T. Staphylococcal cutaneous infections - invasion, evasion and aggression. J Dermatol Sci 42 (2006) 203-214
13. Mempel M., Schnopp C., Hojka H., Fesq S., Weidinger M., Schaller M., et al. Invasion of human keratinocytes by Staphylococcus aureus and intracellular bacterial persistence represent haemolysin-independent virulence mechanisms that are followed by features of necrotic and apoptotic keratinocyte cell death. Br J Dermatol 146 (2002) 943-951
14. Kintarak S., Whawell S.A., Speight P.M., Packer S., and Nair S.P. Internalization of Staphylococcus aureus by human keratinocytes. Infect Immun 72 (2004) 5668-5675
15. Kisich K.O., Howell M.D., Boguniewicz M., Heizer H.R., Watson N.U., and Leung D.Y.M. The constitutive capacity of human keratinocytes to kill Staphylococcus aureus is dependent on β-defensin 3. J Invest Dermatol 127 (2007) 2368-2380
16. Menzies B.E., and Kenoyer A. Staphylococcus aureus infection of epidermal keratinocytes promotes expression of innate antimicrobial peptides. Infect Immun 73 (2005) 5341-5344
17. Walev I., Martin E., Jonas D., Mohamadzadeh M., Muller-Klieser W., Kunz L., et al. Staphylococcal alpha-toxin kills human keratinocytes by permeabilizing the plasma membrane for monovalent ions. Infect Immun 61 (1993) 4972-4979
18. Dinges M.M., Orwin P.M., and Schlievert P.M. Exotoxins of Staphylococcus aureus. Clin Microbiol Rev 13 (2000) 16-34
19. Nair S.P., Williams R.J., and Henderson B. Advances in our understanding of the bone and joint pathology caused by Staphylococcus aureus infection. Rheumatology 39 (2000) 821-834
20. Amagai M., Matsuyoshi N., Wang Z.H., Andl C., and Stanley J.R. Toxin in bullous impetigo and staphylococcal scalded skin syndrome targets desmoglein 1. Nat Med 6 (2000) 1275-1277
21. Wu S., Lim K.C., Huang J., Saidai R.F., and Sears C.L. Bacteroides fragilis enterotoxin cleaves the zonula adherens protein E-cadherin. Proc Natl Acad Sci U S A 95 (1998) 14979-14984
22. Amieva M.R., Vogelmann R., Covacci A., Tompkins L.S., Nelson W.J., and Falkow S. Disruption of the epithelial apical-junctional complex by Helicobacter pylori CagA. Science 300 (2003) 1430-1434
23. Suzuki M., Mimuro H., Suzuki T., Park M., Yamamoto T., and Sasakawa C. Interaction of CagA with Crk plays an important role in Helicobacter pylori-induced loss of gastric epithelial cell adhesion. J Exp Med 202 (2005) 1235-1247
24. Ross J.M. The pathogenesis of anthrax following the administration of spores by the respiratory route. J Pathol Bacteriol 73 (1957) 485-494
25. Reis e Sousa C., Stahl P.D., and Austyn J.M. Phagocytosis of antigens by Langerhans cells in vitro. J Exp Med 178 (1993) 509-519
26. Kripke M.L., Munn C.G., Jeevan A., Tang J.M., and Bucana C. Evidence that cutaneous antigen-presenting cells migrate to regional lymph nodes during contact sensitization. J Immunol 145 (1990) 2833-2838
27. Callegan M.C., Hobden J.A., Hill J.M., Insler M.S., and O'Callaghan R.J. Topical antibiotic therapy for the treatment of experimental Staphylococcus aureus keratitis. Invest Ophthalmol Vis Sci 11 (1992) 3017-3023
28. Cirioni O., Giacometti A., Ghiselli R., Kamysz W., Orlando F., Mocchegiani F., et al. Temporin A alone and in combination with imipenem reduces lethality in a mouse model of staphylococcal sepsis. J Infect Dis 192 (2005) 1613-1620
29. Blaiotta G., Ercolini D., Pennacchia C., Fusco V., Casaburi A., Pepe O., et al. PCR detection of staphylococcal enterotoxin genes in Staphylococcus spp. strains isolated from meat and dairy products. Evidence for new variants of seG and seI in S. aureus AB-8802. J Appl Microbiol 97 (2004) 719-730
30. Monecke S., Berger-Bachi B., Coombs G., Holmes A., Kay I., Kearns A., et al. Comparative genomics and DNA array-based genotyping of pandemic Staphylococcus aureus strains encoding Panton-Valentine leukocidin. Clin Microbiol Infect 13 (2007) 236-249
31. Baba T., Bae T., Schneewind O., Takeuchi F., and Hiramatsu K. Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes - polymorphism and evolution of two major pathogenicity islands. J Bacteriol 190 (2008) 300-310
32. Wardenburg J.B., Palazzolo-Ballance A.M., Otto M., Schneewind O., and DeLeo F.R. Panton-Valentine leucocidin is not a virulence determinant in murine models of community-associated methicillin-resistant Staphylococcus aureus. J Infect Dis 198 (2008) 1166-1170
33. Schwartzman W.A., Beenhouwer D.O., and Schaberg D.R. How relevant were the models used to measure the impact of Panton-Valentine leukocidin in human staphylococcal infections?. J Infect Dis 195 (2007) 1726-1727
34. Sohnle P.G., and Hahn B.L. Effect of immunosuppression on epidermal defenses in a murine model of cutaneous candidiasis. J Lab Clin Med 113 (1989) 700-707
35. Hahn B.L., Sharma S., and Sohnle P.G. Analysis of epidermal entry in experimental cutaneous Bacillus anthracis infections in mice. J Lab Clin Med 146 (2005) 95-102