Baicalin's therapeutic time window of neuroprotection during transient focal cerebral ischemia and its antioxidative effects in vitro and in vivo

Evidence-based Complementary and Alternative Medicine

Volumn 2013, Issue , 2013, Pages

  Cheng, Fafeng ^a   Lu, Yi ^a   Zhong, Xianggen ^a   Song, Wenting ^b   Wang, Xueqian ^a   Sun, Xiaoguang ^a   Qin, Jianguo ^a   Guo, Shaoying ^c   Wang, Qingguo ^a  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^c Central Hospital of Handan   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; ANTIOXIDANT; BAICALIN; DNA NUCLEOTIDYLEXOTRANSFERASE; NEUROPROTECTIVE AGENT; NICOTINAMIDE ADENINE DINUCLEOTIDE KINASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; XANTHINE OXIDASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN ISCHEMIA; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NICK END LABELING; NONHUMAN; PREFRONTAL CORTEX; PRIORITY JOURNAL; RAT; REPERFUSION INJURY;

EID: 84880227169     PISSN: 1741427X     EISSN: 17414288     Source Type: Journal    
DOI: 10.1155/2013/120261     Document Type: Article

References (45)

1. Faraci F. M., Reactive oxygen species: influence on cerebral vascular tone. Journal of Applied Physiology 2006 100 2 739 743 2-s2.0-33646359238 10.1152/japplphysiol.01044.2005
2. Lafon-Cazal M., Pietri S., Culcasi M., Bockaert J., NMDA-dependent superoxide production and neurotoxicity. Nature 1993 364 6437 535 537 2-s2.0-0027221998 10.1038/364535a0
3. Ischiropoulos H., Beckman J. S., Oxidative stress and nitration in neurodegeneration: cause, effect, or association? Journal of Clinical Investigation 2003 111 2 163 169 2-s2.0-0037237927 10.1172/JCI200317638
4. Ezoulin M. J. M., Ombetta J.-E., Dutertre-Catella H., Warnet J.-M., Massicot F., Antioxidative properties of galantamine on neuronal damage induced by hydrogen peroxide in SK-N-SH cells. NeuroToxicology 2008 29 2 270 277 2-s2.0-39749150413 10.1016/j.neuro.2007.11.004
5. Hensley K., Maidt M. L., Yu Z., Sang H., Markesbery W. R., Floyd R. A., Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. Journal of Neuroscience 1998 18 20 8126 8132 2-s2.0-0032531735
6. Lu Y., Wang Q., Melzig M. F., Jenett-Siems K., Extracts of Cynomorium songaricum protect SK-N-SH human neuroblastoma cells against staurosporine-induced apoptosis potentially through their radical scavenging activity. Phytotherapy Research 2009 23 2 257 261 2-s2.0-59449109543 10.1002/ptr.2605
7. Jung S. H., Kang K. D., Ji D., Fawcett R. J., Safa R., Kamalden T. A., Osborne N. N., The flavonoid baicalin counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes. Neurochemistry International 2008 53 6-8 325 337 2-s2.0-56649103692 10.1016/j.neuint.2008.09. 004
8. Liu L.-L., Gong L.-K., Wang H., Xiao Y., Wu X.-F., Zhang Y.-H., Xue X., Qi X.-M., Ren J., Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock. Biochemical Pharmacology 2008 75 4 914 922 2-s2.0-38649087947 10.1016/j.bcp.2007.10.009
9. Li B.-Q., Fu T., Yan Y.-D., Baylor N. W., Ruscetti F. W., Kung H.-F., Inhibition of HIV infection by baicalin-a flavonoid compound purified from Chinese herbal medicine. Cellular and Molecular Biology Research 1993 39 2 119 124 2-s2.0-0027165379
10. Hwang J.-M., Wang C.-J., Chou F.-P., Tseng T.-H., Hsieh Y.-S., Hsu J.-D., Chu C.-Y., Protective effect of baicalin on tert-butyl hydroperoxide-induced rat hepatotoxicity. Archives of Toxicology 2005 79 2 102 109 2-s2.0-14644412937 10.1007/s00204-004-0588-6
11. Li-Weber M., New therapeutic aspects of flavones: the anticancer properties of Scutellaria and its main active constituents Wogonin, Baicalein and Baicalin. Cancer Treatment Reviews 2009 35 1 57 68 2-s2.0-58749114381 10.1016/j.ctrv.2008.09.005
12. Tu X.-K., Yang W.-Z., Shi S.-S., Wang C.-H., Chen C.-M., Neuroprotective effect of baicalin in a rat model of permanent focal cerebral ischemia. Neurochemical Research 2009 34 9 1626 1634 2-s2.0-68349131159 10.1007/s11064-009-9953-4
13. Xu J., Murakami Y., Matsumoto K., Tohda M., Watanabe H., Zhang S., Yu Q., Shen J., Protective effect of Oren-gedoku-to (Huang-Lian-Jie-Du-Tang) against impairment of learning and memory induced by transient cerebral ischemia in mice. Journal of Ethnopharmacology 2000 73 3 405 413 2-s2.0-0033696121 10.1016/S0378-8741(00)00303-2
14. Zhang L., Xing D., Wang W., Wang R., Du L., Kinetic difference of baicalin in rat blood and cerebral nuclei after intravenous administration of Scutellariae Radix extract. Journal of Ethnopharmacology 2006 103 1 120 125 2-s2.0-27944438159 10.1016/j.jep.2005.07.013
15. Fisher M., Feuerstein G., Howells D. W., Hurn P. D., Kent T. A., Savitz S. I., Lo E. H., Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 2009 40 6 2244 2250 2-s2.0-66849097996 10.1161/STROKEAHA.108.541128
16. Xue X., Qu X.-J., Yang Y., Sheng X.-H., Cheng F., Jiang E.-N., Wang J.-H., Bu W., Liu Z.-P., Baicalin attenuates focal cerebral ischemic reperfusion injury through inhibition of nuclear factor B p65 activation. Biochemical and Biophysical Research Communications 2010 403 3-4 398 404 2-s2.0-78650170987 10.1016/j.bbrc.2010.11.042
17. Zhang Z.-J., Li P., Wang Z., Li P.-T., Zhang W.-S., Sun Z.-H., Zhang X.-J., Wang Y.-Y., A comparative study on the individual and combined effects of baicalin and jasminoidin on focal cerebral ischemia-reperfusion injury. Brain Research 2006 1123 1 188 195 2-s2.0-33751292170 10.1016/j.brainres.2006.09.063
18. Cheng F., Zhong X., Lu Y., Wang X., Song W., Guo S., Wang X., Liu D., Wang Q., Refined Qingkailing protects MCAO mice from endoplasmic reticulum stress-induced apoptosis with a broad time window. Evidence-Based Complementary and Alternative Medicine 2012 2012 2-s2.0-84859743115 10.1155/2012/567872 567872
19. Cai Q., Wang H. W., Hua S. Y., Tan J. Z., Zhou T., Li C. S., Neutroprotective efficacy of sodium tanshinone B on hippocampus neuron in a rat model of focal cerebral ischemia. Chinese Journal of Integrative Medicine 18 11 837 845
20. Garcia J. H., Wagner S., Liu K.-F., Hu X.-J., Mohr J. P., Neurological deficit and extent of neuronal necrosis attributable to middle cerebral artery occlusion in rats: statistical validation. Stroke 1995 26 4 627 635 2-s2.0-0028959038
21. Bindokas V. P., Jordán J., Lee C. C., Miller R. J., Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine. Journal of Neuroscience 1996 16 4 1324 1336 2-s2.0-0030008052
22. Girouard H., Wang G., Gallo E. F., Anrather J., Zhou P., Pickel V. M., Iadecola C., NMDA receptor activation increases free radical production through Nitric Oxide and NOX2. Journal of Neuroscience 2009 29 8 2545 2552 2-s2.0-61449176056 10.1523/JNEUROSCI.0133-09.2009
23. Li H., Cai L.-L., Liu J.-G., Liu L.-T., Guan J., Liu M.-F., Hu J., Wei Y., Effect of early intervention with extract of Huannao Yicong Decoction on the pathologic picture of hippocampus and neurocyte apoptosis in APP transgenic mice model of dementia. Chinese Journal of Integrative Medicine 2011 17 6 430 435 2-s2.0-79960122182 10.1007/s11655-011-0752-9
24. Wang Q., Sun A. Y., Simonyi A., Kalogeris T. J., Miller D. K., Sun G. Y., Korthuis R. J., Ethanol preconditioning protects against ischemia/reperfusion- induced brain damage: role of NADPH oxidase-derived ROS. Free Radical Biology and Medicine 2007 43 7 1048 1060 2-s2.0-34548126863 10.1016/j.freeradbiomed. 2007.06.018
25. Whaley-Connell A. T., Morris E. M., Rehmer N., Yaghoubian J. C., Wei Y., Hayden M. R., Habibi J., Stump C. S., Sowers J. R., Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells. American Journal of Nephrology 2007 27 1 15 23 2-s2.0-33847618799 10.1159/000098432
26. Lazzarino G., Tavazzi B., Di Pierro D., Vagnozzi R., Penco M., Giardina B., The relevance of malondialdehyde as a biochemical index of lipid peroxidation of postischemic tissues in the rat and human beings. Biological Trace Element Research 1995 47 1-3 165 170 2-s2.0-0028936236
27. Ka M.-H., Choi E. H., Chun H.-S., Lee K.-G., Antioxidative activity of volatile extracts isolated from Angelica tenuissimae roots, peppermint leaves, pine needles, and sweet flag leaves. Journal of Agricultural and Food Chemistry 2005 53 10 4124 4129 2-s2.0-20844437800 10.1021/jf047932x
28. Gongke Z., Yingzhen K., Kairong C., Zhixiao L., Yafu W., Hydroxyl radical scavenging activity of β -N-oxalyl-L- α β -diaminopropionic acid. Phytochemistry 2001 58 5 759 762 2-s2.0-0035900458 10.1016/S0031-9422(01) 00250-3
29. Toda S., Kumura M., Ohnishi M., Effects of phenolcarboxylic acids on superoxide anion and lipid peroxidation induced by superoxide anion. Planta Medica 1991 57 1 8 10 2-s2.0-0025979060
30. Masuoka N., Isobe T., Kubo I., Antioxidants from Rabdosia japonica. Phytotherapy Research 2006 20 3 206 213 2-s2.0-33645470431 10.1002/ptr.1835
31. Li R., Wang W.-Q., Zhang H., Yang X., Fan Q., Christopher T. A., Lopez B. L., Tao L., Goldstein B. J., Gao F., Ma X. L., Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. American Journal of Physiology 2007 293 6 E1703 E1708 2-s2.0-37149015513 10.1152/ajpendo.00462.2007
32. McCord J. M., Fridovich I., Superoxide dismutase: the first twenty years (1968-1988). Free Radical Biology and Medicine 1988 5 5-6 363 369 2-s2.0-0024212517
33. Kinouchi H., Kamii H., Mikawa S., Epstein C. J., Yoshimoto T., Chan P. H., Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice. Cellular and Molecular Neurobiology 1998 18 6 609 620 2-s2.0-0032410580 10.1023/A:1020213717336
34. Fabian R. H., Perez-Polo J. R., Kent T. A., Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia-ischemia. American Journal of Physiology 2008 295 4 H1809 H1814 2-s2.0-57049119708 10.1152/ajpheart.00301.2007
35. Brennan A. M., Won Suh S., Joon Won S., Narasimhan P., Kauppinen T. M., Lee H., Edling Y., Chan P. H., Swanson R. A., NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation. Nature Neuroscience 2009 12 7 857 863 2-s2.0-67649800742 10.1038/nn.2334
36. Zhou Q. B., Duan C. Z., Jia Q., Liu P., Li L. Y., Baicalin attenuates focal cerebral ischemic reperfusion injury by inhibition of protease-activated receptor-1 and apoptosis. Chinese Journal of Integrative Medicine 2013 10.1007/s11655-013-1441-7
37. Griendling K. K., Sorescu D., Ushio-Fukai M., NAD(P)H oxidase: role in cardiovascular biology and disease. Circulation Research 2000 86 5 494 501 2-s2.0-0034677947
38. Whittemore E. R., Loo D. T., Cotman C. W., Exposure to hydrogen peroxide induces cell death via apoptosis in cultured rat cortical neurons. NeuroReport 1994 5 12 1485 1488 2-s2.0-0027931558
39. Wiswedel I., Ulbricht O., Augustin W., Studies of lipid peroxidation in isolated rat heart mitochondria. Biomedica Biochimica Acta 1989 48 2-3 S73 S76 2-s2.0-0024521367
40. Kober T., König I., Weber M., Kojda G., Diethyldithiocarbamate inhibits the catalytic activity of xanthine oxidase. FEBS Letters 2003 551 1-3 99 103 2-s2.0-0142102559 10.1016/S0014-5793(03)00876-7
41. Pagano P. J., Ito Y., Tornheim K., Gallop P. M., Tauber A. I., Cohen R. A., An NADPH oxidase superoxide-generating system in the rabbit aorta. American Journal of Physiology 1995 268 6 H2274 H2280 2-s2.0-0028997671
42. Cosentino F., Patton S., d'Uscio L. V., Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. The Journal of Clinical Investigation 1998 101 7 1530 1537
43. Wang Y., Huang X., Liang Q. H., A strategy for detecting absorbed bioactive compounds for quality control in the water extract of rhubarb by ultra performance liquid chromatography with photodiode array detector. Chinese Journal of Integrative Medicine 18 9 690 698
44. Zhu X.-L., Xiong L.-Z., Wang Q., Liu Z.-G., Ma X., Zhu Z.-H., Hu S., Gong G., Chen S.-Y., Therapeutic time window and mechanism of tetramethylpyrazine on transient focal cerebral ischemia/reperfusion injury in rats. Neuroscience Letters 2009 449 1 24 27 2-s2.0-56449100898 10.1016/j.neulet.2008.09.007
45. Gao Z., Huang K., Yang X., Xu H., Free radical scavenging and antioxidant activities of flavonoids extracted from the radix of Scutellaria baicalensis Georgi. Biochimica et Biophysica Acta 1999 1472 3 643 650 2-s2.0-0032750323 10.1016/S0304-4165(99)00152-X Drugs